André Luxen
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View article: Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
Author Correction: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
View article: In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
View article: <i>In vivo</i>marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men
<i>In vivo</i>marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men Open
Brain structural integrity has been suggested to contribute to the variability in human sleep quality and composition. The associations between sleep parameters and the regional integrity of subcortical structures implicated in sleep-wake …
View article: In vivo brainstem tau pathology is related to entorhinal amyloid pathology in middle‐aged healthy participants
In vivo brainstem tau pathology is related to entorhinal amyloid pathology in middle‐aged healthy participants Open
Background Braak’s model of Alzheimer’s disease (AD) progression suggests that the initial accumulation of hyperphosphorylated tau protein is seen in the locus coeruleus (LC). Tau pathology might be a good marker of subsequent cognitive de…
View article: Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men
Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men Open
View article: Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers
Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers Open
Insomnia disorder (ID) is the second most common neuropsychiatric disorder. Its socioeconomic burden is enormous while diagnosis and treatment are difficult. A novel approach that reveals associations between insomnia genetic propensity an…
View article: Exercise against cocaine sensitization in mice: a [18F]fallypride micro-PET study
Exercise against cocaine sensitization in mice: a [18F]fallypride micro-PET study Open
Wheel-running exercise in laboratory rodents (animal model useful to study the neurobiology of aerobic exercise) decreases behavioural markers of vulnerability to addictive properties of various drugs of abuse including cocaine. However, n…
View article: In vivo exploration of synaptic projections in frontotemporal dementia
In vivo exploration of synaptic projections in frontotemporal dementia Open
View article: Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status
Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status Open
Studies exploring the simultaneous influence of several physiological and environmental factors on domain-specific cognition in late middle-age remain scarce. Therefore, our objective was to determine the respective contribution of modifia…
View article: Incidental Verbal Semantic Processing Recruits the Fronto-temporal Semantic Control Network
Incidental Verbal Semantic Processing Recruits the Fronto-temporal Semantic Control Network Open
The frontoparietal semantic network, encompassing the inferior frontal gyrus and the posterior middle temporal cortex, is considered to be involved in semantic control processes. The explicit versus implicit nature of these control process…
View article: Author Correction: Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations
Author Correction: Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations Open
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01995-5
View article: The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain
The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain Open
View article: Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging
Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging Open
BACKGROUNDNeuronal hyperexcitability characterizes the early stages of Alzheimer's disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation - both central to AD neuropathology - promote cortical excitability an…
View article: The Pharmacokinetics of [18F]UCB-H Revisited in The Healthy Non-Human Primate Brain
The Pharmacokinetics of [18F]UCB-H Revisited in The Healthy Non-Human Primate Brain Open
Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent…
View article: Association between sleep regulation and neuroimaging-derived myelin markers
Association between sleep regulation and neuroimaging-derived myelin markers Open
Introduction Sleep plays a crucial role in brain plasticity, and has been suggested to be involved in myelin organization. Here we assessed the association between sleep homeostatic responses and quantitative MRI-derived myelin content in …
View article: Higher polygenic risk for insomnia is associated with lower delta power during habitual sleep in young individuals without sleep disorders
Higher polygenic risk for insomnia is associated with lower delta power during habitual sleep in young individuals without sleep disorders Open
peer reviewed
View article: Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness
Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness Open
Study Objectives Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in yo…
View article: Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy
Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy Open
View article: Radical C–H 18F-Difluoromethylation of Heteroarenes with [18F]Difluoromethyl Heteroaryl-Sulfones by Visible Light Photoredox Catalysis
Radical C–H 18F-Difluoromethylation of Heteroarenes with [18F]Difluoromethyl Heteroaryl-Sulfones by Visible Light Photoredox Catalysis Open
The 18F-labeling of CF2H groups has been recently studied in radiopharmaceutical chemistry owing to the favorable nuclear and physical characteristics of the radioisotope 18F for positron emission tomography (PET). Following up on the repo…
View article: Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness Open
Study Objectives Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young a…
View article: Development of a General Automated Flow Photoredox <sup>18</sup>F-Difluoromethylation of N-Heteroaromatics in an AllinOne Synthesizer
Development of a General Automated Flow Photoredox <sup>18</sup>F-Difluoromethylation of N-Heteroaromatics in an AllinOne Synthesizer Open
peer reviewed
View article: Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET
Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET Open
Organic nanoparticles made out of biodegradable and biocompatible materials have attracted increased attention in the therapeutic and diagnostic fields. In this study, we attempted to explore a new radiolabelling chelating free strategy fo…
View article: PET-[18F]UCB-H for assessing synaptic density in FTD
PET-[18F]UCB-H for assessing synaptic density in FTD Open
View article: Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations
Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations Open
View article: Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma
Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma Open
View article: Neuro-functional correlates of protective effects of wheel-running exercise against cocaine locomotor sensitization in mice: a [<sup>18</sup>F]fallypride microPET study
Neuro-functional correlates of protective effects of wheel-running exercise against cocaine locomotor sensitization in mice: a [<sup>18</sup>F]fallypride microPET study Open
Wheel-running exercise in laboratory rodents (animal model useful to study the neurobiology of aerobic exercise) decreases behavioral markers of vulnerability to addictive properties of various drugs of abuse including cocaine. However, ne…
View article: CCDC 1885117: Experimental Crystal Structure Determination
CCDC 1885117: Experimental Crystal Structure Determination Open
View article: CCDC 1885116: Experimental Crystal Structure Determination
CCDC 1885116: Experimental Crystal Structure Determination Open
View article: Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load
Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load Open
We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related cognitive decline. Eighty-one healthy late middle-aged participants (mean age: 59.…
View article: In vivo imaging of synaptic loss in Alzheimer’s disease with [18F]UCB-H positron emission tomography
In vivo imaging of synaptic loss in Alzheimer’s disease with [18F]UCB-H positron emission tomography Open