André Melnik
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Transcriptomic profile assessment for preeclampsia prediction and early diagnostics Open
Aim : to develop a model for predicting preeclampsia (PE) based on the clinically most significant differentially expressed plasma microRNAs. Materials and Methods . A prospective observational comparative study was conducted with 62 women…
Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins Open
Aggregation-prone proteins (APPs) have been implicated in numerous human diseases but the underlying mechanisms are incompletely understood. Here we comparatively analysed cellular responses to different APPs. Our study is based on a syste…
USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit Open
Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase …
The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress Open
Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and …