André U. Deutschmann
YOU?
Author Swipe
View article: Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling
Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling Open
Exposure to adversity during early childhood and adolescence increases an individual's vulnerability to developing substance use disorder. Despite the knowledge of this vulnerability, the mechanisms underlying it are still poorly understoo…
View article: Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes
Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes Open
Significance Opioid use disorder is on the rise, as are efforts to understand vulnerability to misuse. However, understanding resilience to drug abuse is also critical to the development of novel treatments. Here we demonstrate that a brie…
View article: Figure 3
Figure 3 Open
Fig. 3. LBN alters both baseline and morphine-induced glutamate transmission in male but not female rats.
View article: Reversing Cocaine-Induced Plasticity with Zeta Inhibitory Peptide
Reversing Cocaine-Induced Plasticity with Zeta Inhibitory Peptide Open
Cocaine-induced plasticity persists during abstinence and is thought to underlie cue-evoked craving. Reversing this plasticity could provide an opportunity for therapeutic intervention. Converging evidence suggest that zeta inhibitory pept…
View article: Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism
Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism Open
The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in…