André van Zundert
YOU?
Author Swipe
View article: Peri-Operative Dosage and Therapeutic Concentrations of Cefazolin Administered for Surgical Site Infection Prophylaxis in Elective Surgery—A Systematic Review
Peri-Operative Dosage and Therapeutic Concentrations of Cefazolin Administered for Surgical Site Infection Prophylaxis in Elective Surgery—A Systematic Review Open
Background/Objectives: Cefazolin is commonly administered for surgical antibiotic prophylaxis. This review aims to examine whether target unbound plasma and tissue cefazolin concentrations are reached following prophylactic administration …
View article: Rotational thromboelastometry (ROTEM®) and platelet function as measured by Multiplate® in pre-eclamptic women: A prospective observational study.
Rotational thromboelastometry (ROTEM®) and platelet function as measured by Multiplate® in pre-eclamptic women: A prospective observational study. Open
View article: Predicting optimal supraglottic airway device placement: do placement and performance tests measure up?
Predicting optimal supraglottic airway device placement: do placement and performance tests measure up? Open
Background Blind insertion of Supraglottic airway device (SGA) frequently results in suboptimal positioning, with reported incidence rate of 50–80%. Improper placement can lead to perioperative complications such as hypoxia and aspiration.…
View article: Perils of the PICC: Peripherally Inserted Central Catheter-Associated Complications and Recommendations for Prevention in Clinical Practice-A Narrative Review.
Perils of the PICC: Peripherally Inserted Central Catheter-Associated Complications and Recommendations for Prevention in Clinical Practice-A Narrative Review. Open
PICC complications are common, occurring more frequently than other forms of central venous access, and may lead to significant morbidity and mortality. Appropriate assessment of patient risk factors and optimisation strategies may reduce …
View article: Videolaryngoscopy for all: A global proposal for safer airway management
Videolaryngoscopy for all: A global proposal for safer airway management Open
View article: Central Venous Access: An Update on Modern Techniques to Avoid Complications
Central Venous Access: An Update on Modern Techniques to Avoid Complications Open
Background: Central venous catheterization (CVC) is a frequently performed procedure in anesthesia and critical care settings. Modern procedures have improved significantly, particularly with increasingly sophisticated venous verification …
View article: The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue
The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue Open
The use of autologous biological preparations (ABPs) and their combinations fills the void in healthcare treatment options that exists between surgical procedures, like plastic reconstructive, cosmetic, and orthopedic surgeries; non-surgic…
View article: The Cost of Downstream Adverse Outcomes Associated with Allogeneic Blood Transfusion: A Retrospective Observational Cohort Study
The Cost of Downstream Adverse Outcomes Associated with Allogeneic Blood Transfusion: A Retrospective Observational Cohort Study Open
Background: ‘Downstream’ adverse outcomes associated with transfusion-related immune modulation (TRIM) occur postoperatively. The potential associations between these outcomes (and costs) and perioperative transfusion are often not conside…
View article: The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue
The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue Open
The use of autologous biological preparations (ABPs) and their combinations fills a void in health care treatment options that exists between surgical procedures, like plastic reconstructive, cosmetic, orthopedic, non-surgical musculoskele…
View article: Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery
Research Challenges Relating to Immune-Related Patient Outcomes During Blood Transfusion for Spine Surgery Open
Background: In this manuscript, the challenges encountered during research into patient outcomes following transfusion during spine surgery are explored. Method: A narrative review of transfusion research over decades. Results: An estimate…
View article: Profound Properties of Protein-Rich, Platelet-Rich Plasma Matrices as Novel, Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing
Profound Properties of Protein-Rich, Platelet-Rich Plasma Matrices as Novel, Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing Open
Autologous platelet-rich plasma (PRP) preparations are prepared at the point of care. Centrifugation cellular density separation sequesters a fresh unit of blood into three main fractions: a platelet-poor plasma (PPP) fraction, a stratum r…
View article: The growing burden of workplace violence against healthcare workers: trends in prevalence, risk factors, consequences, and prevention – a narrative review
The growing burden of workplace violence against healthcare workers: trends in prevalence, risk factors, consequences, and prevention – a narrative review Open
Workplace violence (WPV) against healthcare workers (HCW) is a globally growing problem in healthcare systems. Despite decades of research and interventions violent incidents are rising in their severity and frequency. A structured review …
View article: Profound Properties of Protein Rich Platelet Concentrate Matrices as Novel Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing
Profound Properties of Protein Rich Platelet Concentrate Matrices as Novel Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing Open
Autologous platelet-rich plasma (PRP) preparations are prepared at point of care. Centrifugation cellular density separation sequesters a fresh unit of blood into three main fractions: a platelet-poor plasma (PPP) fraction, a stratum rich …
View article: Teaching Medical Procedural Skills for Performance
Teaching Medical Procedural Skills for Performance Open
Procedures are a core element of medical professional practice. Today’s training approach was formulated in the mid-twentieth century based on a computer analogue of the brain. Despite minor modifications, the system has remained relativel…
View article: Finger cuff versus invasive and noninvasive arterial pressure measurement in pregnant patients with obesity
Finger cuff versus invasive and noninvasive arterial pressure measurement in pregnant patients with obesity Open
Background Pregnant patients with obesity may have compromised noninvasive blood pressure (NIBP) measurement. We assessed the accuracy and trending ability of the ClearSight™ finger cuff (FC) with invasive arterial monitoring (INV) and arm…
View article: Pre-operative immune cell numbers and ratios are associated with peri-operative adverse outcomes in transfused patients
Pre-operative immune cell numbers and ratios are associated with peri-operative adverse outcomes in transfused patients Open
Background and objectives Transfusion-related immune modulation (TRIM) and associated adverse outcomes during major surgery are increasingly important to patients and health services internationally. A panel of pre-operative blood tests is…
View article: Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents
Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents Open
How general anesthetics work remains a topic of ongoing study. A parallel field of research has sought to identify methods to reverse general anesthesia. Reversal agents could shorten patients’ recovery time and potentially reduce the risk…
View article: Approaches to Teaching Medical Procedural Skills: A Scoping Review
Approaches to Teaching Medical Procedural Skills: A Scoping Review Open
Background. Current approaches to teaching medical procedural skills were developed over 70 years ago. Developments in teaching, movement control, motor learning, educational technology, and understanding of human cognition need to be inte…
View article: Approaches to Teaching Medical Procedural Skills: A Scoping Review
Approaches to Teaching Medical Procedural Skills: A Scoping Review Open
Background. Current approaches to teaching medical procedural skills were developed over 70 years ago. Developments in teaching, movement control, motor learning, educational technology, and understanding of human cognition need to be inte…
View article: Anaesthesia for pelvic exenteration surgery
Anaesthesia for pelvic exenteration surgery Open
View article: The Internet, Apps, and the Anesthesiologist
The Internet, Apps, and the Anesthesiologist Open
Modern anesthesia continues to be impacted in new and unforeseen ways by digital technology. Combining portability and versatility, mobile applications or “apps” provide a multitude of ways to enhance anesthetic and peri-operative care. Re…
View article: Incidence and Factors Related to Prolonged Postoperative Cognitive Decline (POCD) in Elderly Patients Following Surgery and Anaesthesia: A Systematic Review
Incidence and Factors Related to Prolonged Postoperative Cognitive Decline (POCD) in Elderly Patients Following Surgery and Anaesthesia: A Systematic Review Open
This review can only provide limited evidence of prolonged POCD (more than a year) and further research that involves better study designs, larger samples, involving longer follow-up, and at different sites (multicentre) is highly advised.…
View article: The Internet, Apps and the Anesthetist
The Internet, Apps and the Anesthetist Open
Modern anesthesia continues to be impacted in new and unforeseen ways by digital technology. Combining portability and versatility, mobile applications or “apps” provide a multitude of ways to enhance anesthetic and peri-operative care. Re…
View article: Transcutaneous carbon dioxide measurements in anesthetized apneic patients with BMI > 35 kg/m2
Transcutaneous carbon dioxide measurements in anesthetized apneic patients with BMI > 35 kg/m2 Open
Transcutaneous carbon dioxide measurement (TcCO 2 ) offers the ability to continuously and non-invasively monitor carbon dioxide (CO 2 ) tensions when end-tidal monitoring is not possible. The accuracy of TcCO 2 has not been established in…
View article: #36910 How do we define success in regional anesthesia (RA)?
#36910 How do we define success in regional anesthesia (RA)? Open
A successful RA block is the accomplishment of providing a satisfactory central neuraxial, peripheral nerve or plane block using local anesthetic solutions to enable the surgeon/obstetrician to perform certain operations on patients in a …
View article: #36911 Segmental thoracic spinal anesthesia
#36911 Segmental thoracic spinal anesthesia Open
F20 – Segmental Thoracic Spinal Anesthesia Some 15-years ago, we started pioneering work on segmental spinal blocks using the thoracic interspace Th9-Th10. We proved that the combined spinal epidural technique, placing the Tuohy needle in…
View article: #36915 D37 – the green footprint of regional anesthesia
#36915 D37 – the green footprint of regional anesthesia Open
Today, humanity is experiencing unprecedented rapid global warming thrusting us in the midst of our most profound existential crisis. Indeed, climate change is a process due to human activity's – primarily burning fossil fuels and generat…
View article: Clinically Preferred Videolaryngoscopes in Airway Management: An Updated Systematic Review
Clinically Preferred Videolaryngoscopes in Airway Management: An Updated Systematic Review Open
Videolaryngoscopes (VLs) have emerged as a safety net offering several advantages over direct laryngoscopy (DL). The aim of this study is to expand on our previous study conducted in 2016, to deduce which VL is most preferred by clinicians…
View article: A systematic review of predictive accuracy via c-statistic of preoperative frailty tests for extended length of stay, post-operative complications, and mortality
A systematic review of predictive accuracy via c-statistic of preoperative frailty tests for extended length of stay, post-operative complications, and mortality Open
Frailty, as an age-related syndrome of reduced physiological reserve, contributes significantly to post-operative outcomes. With the aging population, frailty poses a significant threat to patients and health systems. Since 2012, preoperat…
View article: Prevention and treatment of noncognitive complications
Prevention and treatment of noncognitive complications Open
Patients aged 65 and older are the fastest growing segment in the population of many countries. Based on evolving demographics showing increasing life expectancies, it is expected that there will be a concurrent rise in the demand for a la…