André Zelanis
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View article: Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application
Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application Open
The escalating global health crisis of antimicrobial resistance demands the urgent development of novel therapeutic agents with new mechanisms of action. Bioactive peptides (BAPs), and specifically antimicrobial peptides (AMPs), represent …
View article: ArtinM Cytotoxicity in B cells derived from Non-Hodgkin’s Lymphoma is regulated by CD45 phosphatase activity and Src family kinases
ArtinM Cytotoxicity in B cells derived from Non-Hodgkin’s Lymphoma is regulated by CD45 phosphatase activity and Src family kinases Open
Receptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific…
View article: A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificity
A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificity Open
View article: Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells
Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells Open
View article: Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases
Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases Open
View article: Data for: Spectral libraries as complementary tools for probing the biochemical diversity of snake venoms
Data for: Spectral libraries as complementary tools for probing the biochemical diversity of snake venoms Open
The spectral librearies.rar file contains the "VenomPeptidome" and "VenomProteome" spectral libraries. Specific instructions on how to use the spectral libraries are provided in the "README.pdf" file.
View article: Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid<i>Phalotris mertensi</i>
Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid<i>Phalotris mertensi</i> Open
Only few studies on snake venoms were dedicated to deeply characterize the toxin secretion of animals from the Colubridae family, despite the fact that they represent the majority of snake diversity. As a consequence, some evolutionary tre…
View article: AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility
AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility Open
Extracellular vesicles play important roles in tumor development. Many components of these structures, including microvesicles and exosomes, have been defined. However, mechanisms by which extracellular vesicles affect tumor progression ar…
View article: Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes
Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes Open
Lance-headed snakes are found in Central and South America, and they account for most snakebites in Brazil. The phylogeny of South American pitvipers has been reviewed, and the presence of natural and non-natural hybrids between different …
View article: Purification, crystallization, crystallographic analysis and phasing of the CRISPR-associated protein Csm2 from <i>Thermotoga maritima</i>
Purification, crystallization, crystallographic analysis and phasing of the CRISPR-associated protein Csm2 from <i>Thermotoga maritima</i> Open
The clusters of regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated proteins (Cas) system consists of an intriguing machinery of proteins that confer bacteria and archaea with immunity against phages and plasmids via…
View article: Data in support of quantitative proteomics to identify potential virulence regulators in Paracoccidioides brasiliensis isolates
Data in support of quantitative proteomics to identify potential virulence regulators in Paracoccidioides brasiliensis isolates Open