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View article: Multiphoton Multicomponent Reactions: Discovery of the 2‐Photon Ketene 4‐Component Reaction (2P‐K‐4CR)
Multiphoton Multicomponent Reactions: Discovery of the 2‐Photon Ketene 4‐Component Reaction (2P‐K‐4CR) Open
Herein, the first multiphoton, multicomponent approach for synthesizing highly functionalized oxetanes using diazoketones, isocyanides, silanols (or carboxylic acids), and 1,2‐dicarbonyl derivatives (benzils) is presented as starting mater…
View article: Photoexcited Palladium Complex-Catalyzed Isocyanide Insertion into Inactivated Alkyl Iodides
Photoexcited Palladium Complex-Catalyzed Isocyanide Insertion into Inactivated Alkyl Iodides Open
Isocyanides insertions represent an important transformation in the palladium-catalyzed reactions landscape. However, one of their most significant limitations is in the use of inactivated alkyl electrophiles. Palladium photocatalysis has …
View article: DESIGN OF AN EDUCATIONAL GAME AND ITS USE IN A TEAM GAME TOURNAMENT AS A STRATEGY TO ENGAGE STUDENTS IN REVIEWING STEREOCHEMISTRY CONCEPTS
DESIGN OF AN EDUCATIONAL GAME AND ITS USE IN A TEAM GAME TOURNAMENT AS A STRATEGY TO ENGAGE STUDENTS IN REVIEWING STEREOCHEMISTRY CONCEPTS Open
This paper presents a Chemistry Team Game Tournament (TGT) as a didactic strategy to review stereochemistry concepts. For this purpose, a multilingual (English, Italian, French, and Portuguese) educational game, Stereochemistry Race, was d…
View article: Expedited access to β-lactams via a telescoped three-component Staudinger reaction in flow
Expedited access to β-lactams via a telescoped three-component Staudinger reaction in flow Open
The Staudinger reaction is widely used for the generation of β-lactams via the thermal cycloaddition of imines with ketenes. Traditionally, it cannot be performed as a multicomponent reaction between aldehydes, amines and ketenes, thus lim…
View article: The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023)
The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023) Open
The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2- a ]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively d…
View article: Total Synthesis of 4-epi-Bengamide E
Total Synthesis of 4-epi-Bengamide E Open
Bengamide E is a bioactive natural product that was isolated from Jaspidae sponges by Crews and co-workers in 1989. It displays a wide range of biological activities, including antitumor, antibiotic, and anthelmintic properties. With the a…
View article: Synthesis of <i>α</i>‐Imino Amidines and 2,3‐Diamino Indolenines Using a One‐Pot Graphene Oxide‐Catalyzed Process
Synthesis of <i>α</i>‐Imino Amidines and 2,3‐Diamino Indolenines Using a One‐Pot Graphene Oxide‐Catalyzed Process Open
The acid‐catalyzed three‐component (3 C) UGI reaction of isocyanides, amines, and aldehydes generally gives α ‐amino amidines. Herein, we report the graphene oxide (GO)‐promoted promoted 3 C Ugi reaction followed by a C−N bond oxidation to…
View article: Two photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction
Two photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction Open
In this paper we report a [2 + 2] cycloaddition reaction between ketenes and benzils, characterized by an unusual double photochemical activation triggered by visible light. Employment of a flow system and optimization of reaction conditio…
View article: Use Cases definition for Culture, Tourism, and Entertainment (CTE) domain
Use Cases definition for Culture, Tourism, and Entertainment (CTE) domain Open
(EC) SNS (Smart Network Services) Joint Undertaking, is an ambitious project that aims to implement large-scale trials of innovative Beyond 5G (B5G) applications. The project will involve the development of 13 representative use cases that…
View article: Use Cases definition for Infrastructure, Transportation and Security & Safety (ITSS)domai
Use Cases definition for Infrastructure, Transportation and Security & Safety (ITSS)domai Open
In the context of WP3 “Work Package 3”, this deliverable D3.1describesthe use cases design, requirements specification, and technologies (software and hardware identification) related to the Infrastructure, Transportation, Security & Safet…
View article: <i>Alcohol or Ethanol?</i> Teaching Organic Chemistry Nomenclature in an Informal Environment
<i>Alcohol or Ethanol?</i> Teaching Organic Chemistry Nomenclature in an Informal Environment Open
The basics of organic chemistry nomenclature were introduced in a laboratory organized in a nonformal environment such as a science festival. The laboratory, divided into three distinct but interconnected activities, was aimed not only at …
View article: Results of a Peer Review Activity Carried out Alternatively on a Compulsory or Voluntary Basis
Results of a Peer Review Activity Carried out Alternatively on a Compulsory or Voluntary Basis Open
A comparative study on the performance and on the perception of two groups of students involved in a peer review activity on the writing of chemical laboratory reports is reported. The first group participated in a compulsory activity, whi…
View article: Visible-Light-Driven Solventylation Strategy for Olefin Functionalization
Visible-Light-Driven Solventylation Strategy for Olefin Functionalization Open
Amphiphilic aryl radicals generated upon visible light irradiation of arylazo sulfones have been exploited in the development of a solventylation strategy via hydrogen atom transfer (HAT). The present protocol succeeded in the versatile fu…
View article: 635 KEYNOTE-495/KeyImPaCT: updated analysis of a biomarker-directed, randomized, phase 2 trial of pembrolizumab-based combination therapy for non-small cell lung cancer
635 KEYNOTE-495/KeyImPaCT: updated analysis of a biomarker-directed, randomized, phase 2 trial of pembrolizumab-based combination therapy for non-small cell lung cancer Open
Background The group sequential, adaptively randomized, open-label, phase 2 KEYNOTE-495/KeyImPaCT trial (NCT03516981) demonstrated the feasibility of using prospective T-cell–inflamed gene expression profile (TcellinfGEP) and tumor mutatio…
View article: Ketene 3‐Component Staudinger Reaction (K‐3CSR) to β‐Lactams: A New Entry in the Class of Photoinduced Multicomponent Reactions
Ketene 3‐Component Staudinger Reaction (K‐3CSR) to β‐Lactams: A New Entry in the Class of Photoinduced Multicomponent Reactions Open
The Staudinger synthesis of β‐lactams from imines and ketenes has been conducted photochemically only in very limited cases. Recent advances in the visible light mediated Wolff rearrangement of diazoketones allowed us to perform, for the f…
View article: Into the Blue: Ketene Multicomponent Reactions under Visible Light
Into the Blue: Ketene Multicomponent Reactions under Visible Light Open
For the first time, a detailed study on the photophysical properties of variously substituted diazoketones and on their photoreactivity under blue LED irradiation was carried out. Despite very limited absorbance in the visible region, we h…
View article: A Thorough Study on the Photoisomerization of Ferulic Acid Derivatives
A Thorough Study on the Photoisomerization of Ferulic Acid Derivatives Open
A thorough study on the ( E ) to ( Z ) photoisomerization of ferulic acid derivatives (esters, amides of all types, and ketones) was carried out. At the photostationary state, only aliphatic or benzylic tertiary amides reach a nearly compl…
View article: The 100 facets of the Passerini reaction
The 100 facets of the Passerini reaction Open
This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction.
View article: Synthesis of Polyoxygenated Heterocycles by Diastereoselective Functionalization of a Bio-Based Chiral Aldehyde Exploiting the Passerini Reaction
Synthesis of Polyoxygenated Heterocycles by Diastereoselective Functionalization of a Bio-Based Chiral Aldehyde Exploiting the Passerini Reaction Open
A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small librar…
View article: Regioselective Photooxidation of Citronellol: A Way to Monomers for Functionalized Bio-Polyesters
Regioselective Photooxidation of Citronellol: A Way to Monomers for Functionalized Bio-Polyesters Open
Dye-sensitized photooxygenation reaction of bio-based double bond-containing substrates is proposed as sustainable functionalization of terpenes and terpenoids to transform them into polyoxygenated compounds to be employed for the synthesi…
View article: Stereodivergent access to all four stereoisomers of chiral tetrahydrobenzo[<i>f</i>][1,4]oxazepines, through highly diastereoselective multicomponent Ugi–Joullié reaction
Stereodivergent access to all four stereoisomers of chiral tetrahydrobenzo[<i>f</i>][1,4]oxazepines, through highly diastereoselective multicomponent Ugi–Joullié reaction Open
Starting from easily accessible enantiopure 1,2-aminoalcohols and salicylaldehydes, a concise and diastereodivergent route to tetrahydrobenzo[f][1,4]oxazepines has been developed.
View article: Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors
Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors Open
While plant polyphenols possess a variety of biological properties, exploration of chemical diversity around them is still problematic. Here, an example of application of the Ugi multicomponent reaction to the combinatorial assembly of art…
View article: Photoredox-Catalyzed Generation of Acetonyl Radical in Flow: Theoretical Investigation and Synthetic Applications
Photoredox-Catalyzed Generation of Acetonyl Radical in Flow: Theoretical Investigation and Synthetic Applications Open
This is the final peer-reviewed manuscript accepted for publication in ACS Catalysis\n\nCitation of the published version is: ACS Catal. 2019, 9, 3, 2493-2500
View article: Editorial: Diversity Oriented Synthesis
Editorial: Diversity Oriented Synthesis Open
EDITORIAL article Front. Chem., 24 January 2019Sec. Organic Chemistry Volume 6 - 2018 | https://doi.org/10.3389/fchem.2018.00668
View article: Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction
Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction Open
Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chi…
View article: Corrigendum: Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds
Corrigendum: Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds Open
Text CorrectionIn the original article, there was an error, as the sentence "The contemporary presence of a secondary amino group and a cyclic ketone kinetically disfavored the Ugi reaction, which did not proceed at room temperature, even …
View article: Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds
Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds Open
[This corrects the article DOI: 10.3389/fchem.2018.00369.].
View article: Photocatalyzed synthesis of isochromanones and isobenzofuranones under batch and flow conditions
Photocatalyzed synthesis of isochromanones and isobenzofuranones under batch and flow conditions Open
Photocatalyzed reactions of 2-(alkoxycarbonyl)benzenediazonium tetrafluoroborates with various alkenes afforded isochromanones in good yields, according to a mechanism that was investigated. The advantage of using highly soluble esters rat…
View article: Towards Intelligent Autonomous Sorting of Unclassified Nuclear Wastes
Towards Intelligent Autonomous Sorting of Unclassified Nuclear Wastes Open
Sorting of old and mixed nuclear waste is an essential process in nuclear decommissioning operations. The main bottleneck is manual picking and separation of the materials using remotely operated arms, which is slow and error prone especia…