Andrea Bellavia
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View article: Statistical approaches for systematically missing covariates in individual participant data meta-analysis: insights and applications using 5 large cardiovascular trials
Statistical approaches for systematically missing covariates in individual participant data meta-analysis: insights and applications using 5 large cardiovascular trials Open
Combining multiple studies for evidence synthesis can improve the precision of effect estimates and enable investigation of more granular clinical research questions. However, individual participant data (IPD) meta-analyses are often limit…
View article: Abuse in Individuals with Multiple Sclerosis: The SocialMS Italian Study
Abuse in Individuals with Multiple Sclerosis: The SocialMS Italian Study Open
Introduction: Abuse is a social determinant of health (SDH) which consists in behaviors used to gain or maintain power and control, including physical, sexual, financial, emotional or psychological actions [1]. In general, individuals with…
View article: Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure
Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure Open
BACKGROUND: SGLT2 (sodium-glucose cotransporter-2) inhibitors reduce the risk of cardiovascular death or worsening heart failure (HF) in outpatients with HF. Data on initiation in patients hospitalized for HF are limited. METHODS: We condu…
View article: The Associations of Foot Process Effacement with Kidney Histopathologic Lesions and Disease Progression
The Associations of Foot Process Effacement with Kidney Histopathologic Lesions and Disease Progression Open
Background: Foot process effacement (FPE), a marker of podocyte injury observable via electron microscopy (EM), plays a key role in the pathophysiology of albuminuria and kidney disease progression. Whether FPE, as reported on kidney biops…
View article: Estimating and presenting non-linear associations with restricted cubic splines
Estimating and presenting non-linear associations with restricted cubic splines Open
Most of the regression models commonly used in epidemiology—including logistic regression and methods for time-to-event outcomes such as Cox regression—define the relationship between a set of covariates and the outcome of interest using l…
View article: Correlations Between Novel Adiposity Indices and Electrocardiographic Evidence of Left Ventricular Hypertrophy in Individuals with Arterial Hypertension
Correlations Between Novel Adiposity Indices and Electrocardiographic Evidence of Left Ventricular Hypertrophy in Individuals with Arterial Hypertension Open
Background/Objectives: Obesity is a key driver of cardiovascular disease (CVD), with central adiposity directly involved in adverse cardiac remodeling. Body mass index (BMI) is limited in capturing fat distribution and associated cardiovas…
View article: Multiple Imputation Approaches for Missing Time-to-Event Outcomes with Informative Censoring: Practical Considerations from a Simulation Study Based on Real Data
Multiple Imputation Approaches for Missing Time-to-Event Outcomes with Informative Censoring: Practical Considerations from a Simulation Study Based on Real Data Open
Missing outcomes data represent a common threat to the validity and robustness of clinical trials with time-to-event outcomes. Recent extensions of multiple imputations (MI), namely controlled-MI, have been introduced as a viable approach …
View article: Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids
Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids Open
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse association betw…
View article: Polybrominated diphenyl ethers and gestational weight gain: a multi‐center prospective cohort study
Polybrominated diphenyl ethers and gestational weight gain: a multi‐center prospective cohort study Open
Objective To evaluate the associations of plasma polybrominated diphenyl ether (PBDE) concentrations in early pregnancy with gestational weight gain (GWG). Design Prospective cohort study. Setting US‐based, multicentre cohort of pregnant w…
View article: Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit
Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit Open
Aims We sought to characterize circulating protein biomarkers associated with cardiogenic shock (CS) using highly multiplex proteomic profiling. Methods and results This analysis employed a cross-sectional case–control study design using a…
View article: Cohort profile: the Environmental Reproductive and Glucose Outcomes (ERGO) Study (Boston, Massachusetts, USA) — a prospective pregnancy cohort study of the impacts of environmental exposures on parental cardiometabolic health
Cohort profile: the Environmental Reproductive and Glucose Outcomes (ERGO) Study (Boston, Massachusetts, USA) — a prospective pregnancy cohort study of the impacts of environmental exposures on parental cardiometabolic health Open
Purpose Pregnancy and the postpartum period are increasingly recognised as sensitive windows for cardiometabolic disease risk. Growing evidence suggests environmental exposures, including endocrine-disrupting chemicals (EDCs), are associat…
View article: Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database
Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database Open
Our results indicate that use of certain medications well before the typically recognized prodromal period was associated with ALS risk. This could result because these medications increase ALS risk or could indicate that ALS symptoms can …
View article: Racial and ethnic disparities in preterm birth: a mediation analysis incorporating mixtures of polybrominated diphenyl ethers
Racial and ethnic disparities in preterm birth: a mediation analysis incorporating mixtures of polybrominated diphenyl ethers Open
Background Racial and ethnic disparities persist in preterm birth (PTB) and gestational age (GA) at delivery in the United States. It remains unclear whether exposure to environmental chemicals contributes to these disparities. Objectives …
View article: 485 Association between perinatal phthalate metabolite concentrations and postpartum glucose levels: a prospective observational study
485 Association between perinatal phthalate metabolite concentrations and postpartum glucose levels: a prospective observational study Open
View article: Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes
Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes Open
OBJECTIVE To develop a risk assessment tool to identify patients with type 2 diabetes (T2D) at higher risk for kidney disease progression and who might benefit more from sodium–glucose cotransporter 2 (SGLT2) inhibition. RESEARCH DESIGN AN…
View article: <strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong>
<strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong> Open
Objective: To develop a risk assessment tool to identify patients with T2D at higher risk for kidney disease progression and who might benefit most from SGLT2 inhibition. Research Design and Methods: 41,…
View article: <strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong>
<strong>Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 inhibition in Patients with Type 2 Diabetes</strong> Open
Objective: To develop a risk assessment tool to identify patients with T2D at higher risk for kidney disease progression and who might benefit most from SGLT2 inhibition. Research Design and Methods: 41,…
View article: Association of Long-term Exposure to Air Pollution and Dementia Risk
Association of Long-term Exposure to Air Pollution and Dementia Risk Open
High levels of homocysteine enhanced the dementia risk attributed to air pollution, while high methionine concentrations reduced this risk. The impact of homocysteine on cardiovascular conditions partly explains this association. Alternati…
View article: P-673 Women exposed to higher levels of DEHP display altered microRNA expression profile in the pre-ovulatory follicular fluid
P-673 Women exposed to higher levels of DEHP display altered microRNA expression profile in the pre-ovulatory follicular fluid Open
Study question Can higher concentrations of di-2-ethylhexyl phthalate (DEHP) in follicular fluid (FF) lead to an altered microRNA expression profile? Summary answer The present study indicates the upregulation of miR-203a-3p, miR-150-5p an…
View article: Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus
Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus Open
View article: The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study
The impact of PM2.5, PM10 and NO2 on Covid-19 severity in a sample of patients with multiple sclerosis: A case-control study Open
View article: The Authors Respond
The Authors Respond Open
To the Editor: We thank Dr. Reyes Sanchez1 for their thoughtful comments on our article. We agree that causal inference assessment should not rely only on statistical methods but also on the evidence of biologic plausibility resulting from…
View article: Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia
Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia Open
View article: Use of gradient boosting machine for exposome-wide analyses: application for pharmaceutical risk factors for amyotrophic lateral sclerosis
Use of gradient boosting machine for exposome-wide analyses: application for pharmaceutical risk factors for amyotrophic lateral sclerosis Open
Background Accumulating evidence suggests that human health is affected by a complex set of exposures, including to environmental toxicants, dietary constituents, psychosocial stressors, and physical factors. Capturing the complexity of th…
View article: Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies
Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies Open
View article: Multiplicative models for survival percentiles: estimating percentile ratios and multiplicative interaction in the metric of time
Multiplicative models for survival percentiles: estimating percentile ratios and multiplicative interaction in the metric of time Open
Evaluating percentiles of survival was proposed as a possible method to analyze time-to-event outcomes. This approach sets the cumulative risk of the event of interest to a specific proportion and evaluates the time by which this proportio…
View article: Urinary phthalate and DINCH metabolite concentrations and gradations of maternal glucose intolerance
Urinary phthalate and DINCH metabolite concentrations and gradations of maternal glucose intolerance Open
Some phthalate biomarkershad trimester-specific associations with glycemic outcomes, with long and short term health implications.
View article: The associations of prenatal exposure to dioxins and polychlorinated biphenyls with neurodevelopment at 6 Months of age: Multi-pollutant approaches
The associations of prenatal exposure to dioxins and polychlorinated biphenyls with neurodevelopment at 6 Months of age: Multi-pollutant approaches Open
View article: Maternal Thyroid Anomalies and Attention-Deficit Hyperactivity Disorder in Progeny
Maternal Thyroid Anomalies and Attention-Deficit Hyperactivity Disorder in Progeny Open
Previous epidemiologic investigations suggested that maternal thyroid anomalies are a possible causal factor in attention-deficit hyperactivity disorder (ADHD) in progeny, yet clinical trials indicated that levothyroxine treatment was inef…
View article: The Associations of Prenatal Exposure to Dioxins and Dioxin-Like Polychlorinated Biphenyls with Neurodevelopment at 6 Months of Age: Multi-pollutant Approaches
The Associations of Prenatal Exposure to Dioxins and Dioxin-Like Polychlorinated Biphenyls with Neurodevelopment at 6 Months of Age: Multi-pollutant Approaches Open
BACKGROUND AND AIM: Prenatal exposure to endocrine disrupting chemicals, including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (DL-PCBs), has been hypothesized…