Andrea Cacciato Insilla
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View article: Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring
Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring Open
Both maternal obesity and postnatal consumption of obesogenic diets contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). However, there is no consensus as to …
View article: An Unexpected Case of Opisthorchis felineus Infection Revealed during Liver Transplantation
An Unexpected Case of Opisthorchis felineus Infection Revealed during Liver Transplantation Open
A man with hepatitis B infection was admitted to Pisa University Hospital for hepatological evaluation, which revealed multiple cystic lesions and suggested a cirrhotic evolution. Treatment with Entecavir 0.5 mg/day was started, resulting …
View article: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.
Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology. Open
Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using i…
View article: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.
Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology. Open
Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using i…
View article: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.
Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology. Open
Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using i…
View article: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.
Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology. Open
Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using i…
View article: Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology.
Supplementary Material for: Mismatch repair deficiency in biliary tract cancer: prognostic implications and correlation with histology. Open
Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using i…
View article: Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model
Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer’s Disease Mouse Model Open
Metabolic impairments and liver and adipose depots alterations were reported in subjects with Alzheimer’s disease (AD), highlighting the role of the liver–adipose–tissue–brain axis in AD pathophysiology. The gut microbiota might play a mod…
View article: Evidence of a Gastro-Duodenal Effect on Adipose Tissue and Brain Metabolism, Potentially Mediated by Gut–Liver Inflammation: A Study with Positron Emission Tomography and Oral 18FDG in Mice
Evidence of a Gastro-Duodenal Effect on Adipose Tissue and Brain Metabolism, Potentially Mediated by Gut–Liver Inflammation: A Study with Positron Emission Tomography and Oral 18FDG in Mice Open
Interventions affecting gastrointestinal (GI) physiology suggest that the GI tract plays an important role in modulating the uptake of ingested glucose by body tissues. We aimed at validating the use of positron emission tomography (PET) w…
View article: Maternal High-Fat Feeding Affects the Liver and Thymus Metabolic Axis in the Offspring and Some Effects Are Attenuated by Maternal Diet Normalization in a Minipig Model
Maternal High-Fat Feeding Affects the Liver and Thymus Metabolic Axis in the Offspring and Some Effects Are Attenuated by Maternal Diet Normalization in a Minipig Model Open
Maternal high-fat diet (HFD) affects metabolic and immune development. We aimed to characterize the effects of maternal HFD, and the subsequent diet-normalization of the mothers during a second pregnancy, on the liver and thymus metabolism…
View article: Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet
Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet Open
Metabolic-associated fatty liver disease is a major cause of chronic pathologies, of which maternal obesity is a frequent risk factor. Gut wall and microbiota, visceral fat, and liver form a pre-systemic network for substrates and pro-infl…
View article: In Reply
In Reply Open
This letter to the editor responds to comments by Hori et al. on the recently published study on intrahepatic cholangiocarcinoma and HER2 positivity rate.
View article: Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study
Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study Open
View article: 7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project)
7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project) Open
View article: Robot-assisted pancreaticoduodenectomy with vascular resection: technical details and results from a high-volume center
Robot-assisted pancreaticoduodenectomy with vascular resection: technical details and results from a high-volume center Open
Background: Pancreaticoduodenectomy with vein resection (PD-VR) is widely accepted as a standard
\nprocedure to achieve a higher rate of R0 resections in borderline resectable pancreatic tumors. Thanks to
\nthe availability of newer techno…
View article: Factors predicting survival in patients with locally advanced pancreatic cancer undergoing pancreatectomy with arterial resection
Factors predicting survival in patients with locally advanced pancreatic cancer undergoing pancreatectomy with arterial resection Open
Pancreatectomy with arterial resection is a treatment option in selected patients with locally advanced pancreatic cancer. This study aimed to identify factors predicting cancer-specific survival in this patient population. A single-Instit…
View article: Sequential Use of Normothermic Regional and Ex Situ Machine Perfusion in Donation After Circulatory Death Liver Transplant
Sequential Use of Normothermic Regional and Ex Situ Machine Perfusion in Donation After Circulatory Death Liver Transplant Open
In Italy, 20 minutes of a continuous flat line on an electrocardiogram are required for declaration of death. In the setting of donation after circulatory death (DCD), prolonged warm ischemia time prompted the introduction of abdominal nor…
View article: HER2 Overexpression as a Poor Prognostic Determinant in Resected Biliary Tract Cancer
HER2 Overexpression as a Poor Prognostic Determinant in Resected Biliary Tract Cancer Open
Background HER2 overexpression has been investigated as a potential biomarker and therapeutic target in biliary tract cancer (BTC), but a prognostic role of such alteration has not been demonstrated yet. Materials and Methods We retrospect…
View article: Tumor Regression Grading Assessment in Locally Advanced Pancreatic Cancer After Neoadjuvant FOLFIRINOX: Interobserver Agreement and Prognostic Implications
Tumor Regression Grading Assessment in Locally Advanced Pancreatic Cancer After Neoadjuvant FOLFIRINOX: Interobserver Agreement and Prognostic Implications Open
Neoadjuvant therapy represents an increasingly used strategy in pancreatic cancer, and this means that more pancreatic resections need to be evaluated for therapy effect. Several grading systems have been proposed for the histological asse…
View article: Early Tumor Shrinkage and Depth of Response Evaluation in Metastatic Pancreatic Cancer Treated with First Line Chemotherapy: An Observational Retrospective Cohort Study
Early Tumor Shrinkage and Depth of Response Evaluation in Metastatic Pancreatic Cancer Treated with First Line Chemotherapy: An Observational Retrospective Cohort Study Open
Early tumor shrinkage (ETS) and depth of response (DoR) predict favorable outcomes in metastatic colorectal cancer. We aim to evaluate their prognostic role in metastatic pancreatic cancer (PC) patients treated with first-line modified-FOL…
View article: TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases
TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases Open
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for …
View article: Metastasis of renal cell carcinoma to the parathyroid gland 16 years after radical nephrectomy: A case report
Metastasis of renal cell carcinoma to the parathyroid gland 16 years after radical nephrectomy: A case report Open
Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metast…
View article: Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature
Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature Open
Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here, a case of LEL-HCC is described. An 81-year-old woma…