Andrea Caddeo
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View article: Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes Open
View article: Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells
Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells Open
Plastic compounds released into the environment can be accumulated in human tissues causing various health issues. It has been demonstrated that Bisphenol A (BPA), widely used in polycarbonate plastics and food packaging, can accumulate in…
View article: Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model
Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model Open
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, and liver-related morbidity and mortality worldwide. MASLD is a multifactorial condition, which still needs to be co…
View article: TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD”
TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD” Open
View article: Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity and mortality. MASLD spans from isolated steatosis to metabolic dysfunction-asso…
View article: Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity Open
Background Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndrome. However, our u…
View article: 3D culture models to study pathophysiology of steatotic liver disease
3D culture models to study pathophysiology of steatotic liver disease Open
Steatotic liver disease (SLD) refers to a spectrum of diseases caused by hepatic lipid accumulation. SLD has emerged as the leading cause of chronic liver disease worldwide. Despite this burden and many years, understanding the pathophysio…
View article: IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids Open
View article: <scp>MBOAT7</scp> in liver and extrahepatic diseases
<span>MBOAT7</span> in liver and extrahepatic diseases Open
MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated fatty acids. Genetic variants in the MBOAT7 gene have been associa…
View article: Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes
Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes Open
Background and Aims: Cancer cells reprogram their metabolic pathways to support bioenergetic and biosynthetic needs and to maintain their redox balance. In several human tumors, the Keap1-Nrf2 system controls proliferation and metabolic re…
View article: Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis
Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis Open
Introduction Several lines of evidence suggest that the thyroid hormone signaling pathway is altered in patients with NAFLD and that pharmacological strategies to target the thyroid hormone/thyroid hormone nuclear receptor axis (TH/THR) in…
View article: TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD
TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD Open
Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). Here, we investigated the effect of TG68, a novel THRβ agonist, on fatty liver accu…
View article: LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol
LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol Open
View article: Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability Open
View article: LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover Open
Objective Non-alcoholic fatty liver disease (NAFLD) is a common prelude to cirrhosis and hepatocellular carcinoma. The genetic rs641738 C>T variant in the lysophosphatidylinositol acyltransferase 1 ( LPIAT1)/membrane bound O-acyltransferas…
View article: MANAGING PLANT INVASIONS USING LEGISLATION TOOLS: AN ANALYSIS OF THE NATIONAL AND REGIONAL REGULATIONS FOR NON-NATIVE PLANTS IN ITALY
MANAGING PLANT INVASIONS USING LEGISLATION TOOLS: AN ANALYSIS OF THE NATIONAL AND REGIONAL REGULATIONS FOR NON-NATIVE PLANTS IN ITALY Open
The integration of international, national and local regulations is one of the fundamental steps for preventing, controlling and managing biological invasions. The aim of the present study is to present and analyse, for the first time, the…
View article: The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids Open
There is a high unmet need for developing treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a human in vitro disease model to understand mechanisms linked to genetic risk va…
View article: MBOAT7 is anchored to endomembranes by six transmembrane domains
MBOAT7 is anchored to endomembranes by six transmembrane domains Open
Membrane bound O-acyltransferase domain- containing 7 (MBOAT7, also known as LPIAT1) is a protein involved in the acyl chain remodeling of phospholipids via the Lands’ cycle. The MBOAT7 is a susceptibility risk genetic locus for non-alcoho…
View article: Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia
Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia Open
View article: Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease
Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease Open
In an increasing proportion of cases, hepatocellular carcinoma ( HCC ) develops in patients with nonalcoholic fatty liver disease ( NAFLD ). Mutations in telomerase reverse transcriptase ( hTERT ) are associated with familial liver disease…
View article: PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis
PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis Open
Liver fibrosis is a pathological scarring response to chronic hepatocellular injury and hepatic stellate cells (HSCs) are key players in this process. PNPLA3 I148M is a common variant robustly associated with liver fibrosis but the mechani…