Andrea Colizza
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View article: Correction: Partial Horizontal Supracricoid Laryngectomy: Which Factors Impact on Post-decannulation Swallowing Outcomes? A Prospective Single-Center Experience
Correction: Partial Horizontal Supracricoid Laryngectomy: Which Factors Impact on Post-decannulation Swallowing Outcomes? A Prospective Single-Center Experience Open
View article: Novel Pathogenic Variant Confirms the Association of <i>REST</i> and Jones Syndrome
Novel Pathogenic Variant Confirms the Association of <i>REST</i> and Jones Syndrome Open
Jones syndrome (JS) is an ultra‐rare autosomal dominant condition characterized by gingival fibromatosis and progressive sensorineural hearing loss. It has been recently demonstrated in members of a Finnish family to co‐segregate with hete…
View article: Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis
Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis Open
Introduction: Polycystic ovary syndrome (PCOS) is a common hormonal disorder among young women, correlated with hyperandrogenism. Among the symptoms of PCOS, vocal alterations are quite unknown. Dysphonia may be related to hy…
View article: Montgomery Salivary Bypass Tube vs Self-Expandable Metal Stents for the treatment of esophageal strictures after total laryngectomy: a crossover study.
Montgomery Salivary Bypass Tube vs Self-Expandable Metal Stents for the treatment of esophageal strictures after total laryngectomy: a crossover study. Open
In patients who are already undergoing cyclic dilations and application of MSBT, switching to SEMS is not beneficial. Furthermore, MSBT has a significantly shorter implant procedure, does not expose the patient to X-rays, and, in the absen…
View article: Reduced expression of secretogranin VGF in laryngeal squamous cell carcinoma
Reduced expression of secretogranin VGF in laryngeal squamous cell carcinoma Open
Laryngeal cancer accounts for one-third of all head and neck tumors, with squamous cell carcinoma (SCC) being the most predominant type, followed by neuroendocrine tumors. Chromogranins, are commonly used as biomarkers for neuroendocrine t…
View article: A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland
A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland Open
Background. The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, a subgroup of this tumor presents an aggressive behavior with a tendency to recur. The aim of this multicenter study was…
View article: Statins Effect on Oncologic Outcome in Larynx Squamous Cell Carcinoma: Commentary on Our Clinical Experience
Statins Effect on Oncologic Outcome in Larynx Squamous Cell Carcinoma: Commentary on Our Clinical Experience Open
Background Some studies have suggested a protective role of statins in Head and Neck Squamous Cell Carcinoma (HNSCC) even though the real contribution of statins to morbidity and survival remains unclear. Porpose The aim of this study is t…
View article: The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study
The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study Open
Alcohol consumption is associated with oxidative stress and an increased risk of carcinoma of the upper aero-digestive tract (UADT). Recently, it has been found that some microorganisms in the human oral cavity may locally metabolize ethan…
View article: Partial Horizontal Supracricoid Laryngectomy: Which Factors Impact on Post-decannulation Swallowing Outcomes? A Prospective Single-Center Experience
Partial Horizontal Supracricoid Laryngectomy: Which Factors Impact on Post-decannulation Swallowing Outcomes? A Prospective Single-Center Experience Open
View article: Treatment of relapses of benign latero-cervical pathology: a narrative literature review
Treatment of relapses of benign latero-cervical pathology: a narrative literature review Open
Benign laterocervical pathologies are not without pitfalls. Many may relapse after many years and, sometimes, they cannot be predicted. The purpose of this review is to describe the surgical measures necessary for the treatment of relapses…
View article: Clinico-histopathological review of 255 patients who underwent parotidectomy for pleomorphic adenoma: a 10-year retrospective study—a proposal for an optimal diagnostic and therapeutic algorithm for patients with recurrent pleomorphic adenoma
Clinico-histopathological review of 255 patients who underwent parotidectomy for pleomorphic adenoma: a 10-year retrospective study—a proposal for an optimal diagnostic and therapeutic algorithm for patients with recurrent pleomorphic adenoma Open
Purpose Pleomorphic adenoma (mixed tumor) is the most common neoplasm of the parotid gland and one of the most frequent types of salivary gland tumor, generally with benign behavior and relatively slow growing. The adenomas could arise fro…
View article: HAX1 Is a Novel Binding Partner of Che-1/AATF. Implications in Oxidative Stress Cell Response
HAX1 Is a Novel Binding Partner of Che-1/AATF. Implications in Oxidative Stress Cell Response Open
HAX1 is a multifunctional protein involved in the antagonism of apoptosis in cellular response to oxidative stress. In the present study we identified HAX1 as novel binding partner for Che-1/AATF, a pro-survival factor which plays a crucia…
View article: Otolaryngology Conditions and Diseases in Migrants: The Experience of the PROTECT Project
Otolaryngology Conditions and Diseases in Migrants: The Experience of the PROTECT Project Open
Introduction: The number of migrants living in Europe is growing rapidly. The PROTECT project is a national study conducted among refugees and migrants in the Lazio region, Italy from February 2018 to September 2021 to evaluate their otola…
View article: SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts: Novel Insights in Pathophysiology of Spinal Muscular Atrophy
SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts: Novel Insights in Pathophysiology of Spinal Muscular Atrophy Open
The deficiency of survival motor neuron protein (SMN) causes spinal muscular atrophy (SMA), a rare neuromuscular disease that affects different organs. SMN is a key player in RNA metabolism regulation. An intriguing aspect of SMN function …
View article: The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma
The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysreg…
View article: Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?
Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)? Open
Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy w…
View article: SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts. Novel Insights in Pathophysiology of Spinal Muscular Atrophy
SMN Deficiency Destabilizes ABCA1 Expression in Human Fibroblasts. Novel Insights in Pathophysiology of Spinal Muscular Atrophy Open
The deficiency of Survival Motor Neuron (SMN) protein causes Spinal Muscular Atrophy (SMA), a rare neuromuscular disease that affects different organs. SMN is a key player in RNA metabolism regulation. An intriguing aspect of SMN function …
View article: 3D Printing in Otolaryngology Surgery: Descriptive Review of Literature to Define the State of the Art
3D Printing in Otolaryngology Surgery: Descriptive Review of Literature to Define the State of the Art Open
Background: Three-dimensional (3D) printing has allowed great progression in the medical field. In otolaryngology practice, 3D printing can be used for planning in case of malformation/complex surgery, for surgeon training, and for recreat…
View article: The RNA-binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma
The RNA-binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) arise from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysregu…
View article: Programmed Cell Death-Ligand 1 in Head and Neck Squamous Cell Carcinoma: Molecular Insights, Preclinical and Clinical Data, and Therapies
Programmed Cell Death-Ligand 1 in Head and Neck Squamous Cell Carcinoma: Molecular Insights, Preclinical and Clinical Data, and Therapies Open
Aberrant expression of the programmed cell death protein ligand 1 (PD-L1) constitutes one of the main immune evasion mechanisms of cancer cells. The approval of drugs against the PD-1-PD-L1 axis has given new impetus to the chemo-therapy o…
View article: Surgical Excision of Unusual Sacked Neck and Mediastinum Abscess of Odontogenic Origin
Surgical Excision of Unusual Sacked Neck and Mediastinum Abscess of Odontogenic Origin Open
The most common cause of neck infections is odontogenic abscesses that can often be life-threatening and require a surgical drain associated with antibiotic therapy. We present a case of the surgical management of an odontogenic sack-shape…
View article: Anesthetic and surgical management of tracheotomy in a patient with Kennedy's Disease.
Anesthetic and surgical management of tracheotomy in a patient with Kennedy's Disease. Open
In KD local anesthesia should be preferred to general anesthesia as general anesthesia is associated with increased potential for laryngospasm, pulmonary aspiration, and respiratory insufficiency related to the use of neuromuscular blockin…
View article: Systematic Review of Parotid Gland Sarcomas: Multi-Variate Analysis of Clinicopathologic Findings, Therapeutic Approaches and Oncological Outcomes That Affect Survival Rate
Systematic Review of Parotid Gland Sarcomas: Multi-Variate Analysis of Clinicopathologic Findings, Therapeutic Approaches and Oncological Outcomes That Affect Survival Rate Open
The aim of this study was to systematically review the literature of sarcoma of the parotid gland in order to analyze the main factors affecting survival rate. A systematic literature review was performed between January 1990 to November 2…
View article: STATINS EFFECT ON ONCOLOGIC OUTCOME IN LARYNX SQUAMOUS CELL CARCINOMA: A COMMENTARY ON OUR CLINICAL EXPERIENCE
STATINS EFFECT ON ONCOLOGIC OUTCOME IN LARYNX SQUAMOUS CELL CARCINOMA: A COMMENTARY ON OUR CLINICAL EXPERIENCE Open
Purpose: Some studies have suggested a protective role of statins in Head and Neck Squamous Cell Carcinoma (HNSCC) even though the real contribution of statins to morbidity and survival remains unclear. Study Design: Retrospective case-con…
View article: Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration
Sudden Sensorineural Hearing Loss after Third Dose Booster of COVID-19 Vaccine Administration Open
Coronavirus disease 2019 (COVID-19) was declared a pandemic due to its rapid spread worldwide, and its vaccination campaign is considered one of the most historic public hygiene measures in modern medicine. Sudden sensorineural hearing los…
View article: Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach Open
Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical techniques used for the conservative management of laryngeal cancers. The aims of this study are to analyze the oncological and functional results of a group…
View article: Investigational drugs for the treatment of olfactory dysfunction
Investigational drugs for the treatment of olfactory dysfunction Open
Because COVID-19 causes olfactory loss and several treatments (topical and systemic) have been tested in this disease, we have decided to use this model of acquired olfactory loss to discuss the different therapeutical option. The authors …
View article: Dental Implant Failure Risk in Post Oncological Patients, a Retrospective Study and Sapienza Head and Neck Unit Decisional Protocol- 7 Years of Follow-Up
Dental Implant Failure Risk in Post Oncological Patients, a Retrospective Study and Sapienza Head and Neck Unit Decisional Protocol- 7 Years of Follow-Up Open
(1) Background: Patients with head and neck cancer are treated by ablative surgery, radiotherapy, chemotherapy, or a combination of these. The side effects of cancer therapies can compromise conventional prosthesis rehabilitation; therefor…
View article: Oscillometry in total laryngectomized patients: A case study
Oscillometry in total laryngectomized patients: A case study Open
Attempts to analyze respiratory function of the laryngectomized patient with tests such as spirometry and plethysmography have been described in the literature, highlighting however substantial difficulties. Oscillometry, through the force…
View article: Benralizumab reduces eosinophils and inflammatory markers in patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: A pilot real-life study.
Benralizumab reduces eosinophils and inflammatory markers in patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: A pilot real-life study. Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) and Severe Eosinophilic Asthma (SEA) are both frequently sustained by eosinophilic inflammation and are probably the manifestation of a unique disease of upper and lower respiratory tract. …