Andrea E. Steuer
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View article: A 28-Year-Old Man With Consecutive Gastrointestinal Symptoms, Kidney Failure, and Progressive Neurologic Deterioration
A 28-Year-Old Man With Consecutive Gastrointestinal Symptoms, Kidney Failure, and Progressive Neurologic Deterioration Open
A 28-year-old man with an unremarkable medical history, no regular medication regimen, and no recent travel history or animal exposure was admitted to the emergency department with new onset of disorientation, slurred speech, and hearing l…
View article: Fatal intoxication involving amphetamine, clonazafone, a benzodiazepine prodrug, and fluoro-etonitazene, a new synthetic opioid
Fatal intoxication involving amphetamine, clonazafone, a benzodiazepine prodrug, and fluoro-etonitazene, a new synthetic opioid Open
Intoxication cases involving new psychoactive substances (NPS) are known to provide various challenges for forensic toxicological case interpretation, starting with the identification of previously unknown substances. Furthermore, the phar…
View article: Prolonged Detection of GHB Intake in Urine: Are We Finally There?
Prolonged Detection of GHB Intake in Urine: Are We Finally There? Open
Gamma‐hydroxybutyric acid (GHB) has been implicated in drug‐facilitated sexual assault (DFSA). However, due to its rapid elimination and the challenge of distinguishing exogenous from endogenous levels, GHB is likely to be significantly un…
View article: Differential alterations in peripheral tryptophan pathways in methamphetamine versus MDMA users are linked to their contrasting psychiatric symptoms
Differential alterations in peripheral tryptophan pathways in methamphetamine versus MDMA users are linked to their contrasting psychiatric symptoms Open
Methamphetamine (METH, “Crystal Meth”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) are two types of substituted amphetamines that share structural-chemical similarities but exhibit contrasting acute and chronic effects includin…
View article: New Approaches To Identify Urine and Hair Adulteration Attempts in Forensic Toxicology: A Proof-of-Concept Study Using a Proteomics Approach Based on Liquid Chromatography–Mass Spectrometry (LC-MS)
New Approaches To Identify Urine and Hair Adulteration Attempts in Forensic Toxicology: A Proof-of-Concept Study Using a Proteomics Approach Based on Liquid Chromatography–Mass Spectrometry (LC-MS) Open
Urine and hair are among the primary biological matrices used for drug and abstinence testing in clinical, forensic, and antidoping settings. A persistent challenge in such analyses is the adulteration of samples: through dilution, substit…
View article: Evaluation of Bladder Wash as an Alternative Specimen for Postmortem Toxicology: Comparison to Screening Results of Urine and Kidney Tissue
Evaluation of Bladder Wash as an Alternative Specimen for Postmortem Toxicology: Comparison to Screening Results of Urine and Kidney Tissue Open
Urine specimens represent the gold standard for screening analyses in forensic toxicology, but they are not always available postmortem. In this case, alternative specimens must be considered. The current study aimed to systematically eval…
View article: Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry
Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry Open
Bioanalysis, such as the quantification of drugs in different matrices, is of great importance in forensic toxicology. Nowadays, mainly so‐called multianalyte approaches are used given their increased speed and effectiveness. However, such…
View article: Assessing the influence of sleep and sampling time on metabolites in oral fluid: implications for metabolomics studies
Assessing the influence of sleep and sampling time on metabolites in oral fluid: implications for metabolomics studies Open
Introduction The human salivary metabolome is a rich source of information for metabolomics studies. Among other influences, individual differences in sleep-wake history and time of day may affect the metabolome. Objectives We aimed to cha…
View article: Impact of three different peak picking software tools on the quality of untargeted metabolomics data
Impact of three different peak picking software tools on the quality of untargeted metabolomics data Open
View article: Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning?
Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning? Open
Introduction The (un)targeted analysis of endogenous compounds has gained interest in the field of forensic postmortem investigations. The blood metabolome is influenced by many factors, and postmortem specimens are considered particularly…
View article: Chemical cousins with contrasting behavioural profiles: MDMA users and methamphetamine users differ in social-cognitive functions and aggression
Chemical cousins with contrasting behavioural profiles: MDMA users and methamphetamine users differ in social-cognitive functions and aggression Open
Methamphetamine (METH, "Crystal Meth") and 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") share structural-chemical similarities but have distinct psychotropic profiles due to specific neurochemical actions. Previous research has sugg…
View article: Is it dopamine or serotonin?: Contrasting social cognition and aggression between chronic MDMA and methamphetamine users
Is it dopamine or serotonin?: Contrasting social cognition and aggression between chronic MDMA and methamphetamine users Open
View article: Serotonergic plasticity beyond the brain? Contrasting effects of chronic MDMA vs. methamphetamine use on peripheral serotonin pathways
Serotonergic plasticity beyond the brain? Contrasting effects of chronic MDMA vs. methamphetamine use on peripheral serotonin pathways Open
View article: Analytical description of adolescent binge drinking patients
Analytical description of adolescent binge drinking patients Open
View article: Preliminary Investigation of Side Effects of Polymyxin B Administration in Hospitalized Horses
Preliminary Investigation of Side Effects of Polymyxin B Administration in Hospitalized Horses Open
Data set to the publication: https://doi.org/10.3390/antibiotics12050854
View article: Advances in testing for sample manipulation in clinical and forensic toxicology - Part A: urine samples
Advances in testing for sample manipulation in clinical and forensic toxicology - Part A: urine samples Open
View article: Preliminary Investigation of Side Effects of Polymyxin B Administration in Hospitalized Horses
Preliminary Investigation of Side Effects of Polymyxin B Administration in Hospitalized Horses Open
Data set to the publication: https://doi.org/10.3390/antibiotics12050854
View article: Advances in testing for sample manipulation in clinical and forensic toxicology—part B: hair samples
Advances in testing for sample manipulation in clinical and forensic toxicology—part B: hair samples Open
View article: Do dried blood spots have the potential to support result management processes in routine sports drug testing?—Part 3: LC–MS/MS‐based peptide analysis for dried blood spot sampling time point estimation
Do dried blood spots have the potential to support result management processes in routine sports drug testing?—Part 3: LC–MS/MS‐based peptide analysis for dried blood spot sampling time point estimation Open
Along with the recent acknowledgement of the World Anti‐Doping Agency to use dried blood spot (DBS) samples for routine doping control purposes, there have been propositions to use DBS as a matrix that allows regular proactive remotely sup…
View article: Metabolomics-based Sleepiness Markers for Risk Prevention and Traffic Safety (ME-SMART): a monocentric, controlled, randomized, crossover trial
Metabolomics-based Sleepiness Markers for Risk Prevention and Traffic Safety (ME-SMART): a monocentric, controlled, randomized, crossover trial Open
Background Too little sleep and the consequences thereof are a heavy burden in modern societies. In contrast to alcohol or illicit drug use, there are no quick roadside or workplace tests for objective biomarkers for sleepiness. We hypothe…
View article: Additional file 1 of Analytical description of adolescent binge drinking patients
Additional file 1 of Analytical description of adolescent binge drinking patients Open
Supplementary Material 1
View article: Easy and convenient millimole‐scale synthesis of new, potential biomarkers for gamma‐hydroxybutyric acid (GHB) intake: Feasible for analytical laboratories
Easy and convenient millimole‐scale synthesis of new, potential biomarkers for gamma‐hydroxybutyric acid (GHB) intake: Feasible for analytical laboratories Open
New biomarkers indicating the abuse of drugs and alcohol are still of major interest for clinical and forensic sciences. The endogenous neurotransmitter and approved drug, gamma‐hydroxybutyric acid (GHB), is often illegally used for drug‐f…
View article: Towards a New Qualitative Screening Assay for Synthetic Cannabinoids Using Metabolomics and Machine Learning
Towards a New Qualitative Screening Assay for Synthetic Cannabinoids Using Metabolomics and Machine Learning Open
Background Synthetic cannabinoids (SCs) are steadily emerging on the drug market. To remain competitive in clinical or forensic toxicology, new screening strategies including high-resolution mass spectrometry (HRMS) are required. Machine l…
View article: Microbial Communities and Processes in Biofilters for Post-Treatment of Ozonated Wastewater Treatment Plant Effluent
Microbial Communities and Processes in Biofilters for Post-Treatment of Ozonated Wastewater Treatment Plant Effluent Open
View article: Untargeted metabolomics approaches to improve casework in clinical and forensic toxicology—“Where are we standing and where are we heading?”
Untargeted metabolomics approaches to improve casework in clinical and forensic toxicology—“Where are we standing and where are we heading?” Open
Clinical toxicology (CT) and forensic toxicology (FT) represent two disciplines of toxicology dedicated to the qualitative and quantitative analysis and respective interpretation of alcohol, drugs of abuse (DOA), over the counter (OTC), an…
View article: Postmortem Metabolomics: Strategies to Assess Time-Dependent Postmortem Changes of Diazepam, Nordiazepam, Morphine, Codeine, Mirtazapine and Citalopram
Postmortem Metabolomics: Strategies to Assess Time-Dependent Postmortem Changes of Diazepam, Nordiazepam, Morphine, Codeine, Mirtazapine and Citalopram Open
Postmortem redistribution (PMR) can result in artificial drug concentration changes following death and complicate forensic case interpretation. Currently, no accurate methods for PMR prediction exist. Hence, alternative strategies were de…
View article: Significance of Metabolite Ratios in the Interpretation of Segmental Hair Testing Results—Differentiation of Single from Chronic Morphine Use in a Case Series
Significance of Metabolite Ratios in the Interpretation of Segmental Hair Testing Results—Differentiation of Single from Chronic Morphine Use in a Case Series Open
In morphine intoxication cases, forensic toxicologists are frequently confronted with the question of if the individual was opioid-tolerant or opioid-naïve, which can be investigated by hair analysis. However, interpretation of results can…
View article: Interpretable machine learning model to detect chemically adulterated urine samples analyzed by high resolution mass spectrometry
Interpretable machine learning model to detect chemically adulterated urine samples analyzed by high resolution mass spectrometry Open
Objectives Urine sample manipulation including substitution, dilution, and chemical adulteration is a continuing challenge for workplace drug testing, abstinence control, and doping control laboratories. The simultaneous detection of sampl…
View article: Towards Extending the Detection Window of Gamma-Hydroxybutyric Acid—An Untargeted Metabolomics Study in Serum and Urine Following Controlled Administration in Healthy Men
Towards Extending the Detection Window of Gamma-Hydroxybutyric Acid—An Untargeted Metabolomics Study in Serum and Urine Following Controlled Administration in Healthy Men Open
In forensic toxicology, gamma-hydroxybutyrate (GHB) still represents one of the most challenging drugs of abuse in terms of analytical detection and interpretation. Given its rapid elimination, the detection window of GHB in common matrice…
View article: Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color
Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color Open
Untargeted metabolomic studies are used for large-scale analysis of endogenous compounds. Due to exceptional long detection windows of incorporated substances in hair, analysis of hair samples for retrospective monitoring of metabolome cha…