Andrea Ferreira‐Gonzalez
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View article: Barriers and facilitators to next-generation sequencing use in United States oncology settings: a systematic review
Barriers and facilitators to next-generation sequencing use in United States oncology settings: a systematic review Open
Aim: Next-generation sequencing (NGS) of solid tumors can inform treatment decisions; however, uptake remains low. This objective of this systematic review was to identify barriers to and facilitators of NGS in US oncology settings.Materia…
View article: Next-Generation Sequencing Trends among Adult Patients with Select Advanced Tumor Types
Next-Generation Sequencing Trends among Adult Patients with Select Advanced Tumor Types Open
There are limited data on the prevalence of next-generation sequencing (NGS) in the United States, especially in light of the increasing importance of identifying actionable oncogenic variants due to molecular biomarker-based therapy appro…
View article: P615: Low rate of clinical follow-up for potential germline variants identified in hematologic malignancies with a next generation sequencing panel
P615: Low rate of clinical follow-up for potential germline variants identified in hematologic malignancies with a next generation sequencing panel Open
Somatic tests are used routinely in clinical practice to identify variants present in a malignancy. While somatic testing cannot definitively identify germline variants, it can raise suspicion of this possibility. Potentially germline vari…
View article: Stratification of Tamoxifen Synergistic Combinations for the Treatment of ER+ Breast Cancer
Stratification of Tamoxifen Synergistic Combinations for the Treatment of ER+ Breast Cancer Open
Breast cancer alone accounts for the majority of cancer deaths among women, with the most commonly diagnosed subtype being estrogen receptor positive (ER+). Survival has greatly improved for patients with ER+ breast cancer, due in part to …
View article: Data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Inhibitors targeting BCL-2 apoptotic proteins have significant potential for the treatment of acute myeloid leukemia (AML); however, complete responses are observed in only 20% of patients, suggesting that targeting BCL-2 alone is insuffic…
View article: Legends to Supplementary data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Legends to Supplementary data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Legends to Supplementary Figures
View article: Supplementary Figures from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Supplementary Figures from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Supplementary Figures S1: Activity of combined treatment with venetoclax and GDC-0980 in human AML cells. Supplementary Figures S1: Synergistic interaction between venetoclax and GDC-0980 using median dose effect analysis. Supplementary Fi…
View article: Supplementary Figures from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Supplementary Figures from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Supplementary Figures S1: Activity of combined treatment with venetoclax and GDC-0980 in human AML cells. Supplementary Figures S1: Synergistic interaction between venetoclax and GDC-0980 using median dose effect analysis. Supplementary Fi…
View article: Legends to Supplementary data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Legends to Supplementary data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Legends to Supplementary Figures
View article: Data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Data from Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells Open
Inhibitors targeting BCL-2 apoptotic proteins have significant potential for the treatment of acute myeloid leukemia (AML); however, complete responses are observed in only 20% of patients, suggesting that targeting BCL-2 alone is insuffic…
View article: Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 54K, Mutations analysis in primary leukemia blasts.
View article: Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 64K, Primary antibodies and cell lines generation
View article: Data from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Data from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
Effects of concomitant inhibition of the PI3K/AKT/mTOR pathway and Bcl-2/Bcl-xL (BCL2L1) were examined in human myeloid leukemia cells. Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethal…
View article: Data from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Data from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
Effects of concomitant inhibition of the PI3K/AKT/mTOR pathway and Bcl-2/Bcl-xL (BCL2L1) were examined in human myeloid leukemia cells. Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethal…
View article: Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 579K, Supplemantary Figure 1: Bcl-2 and Bcl-xL determine sensitivity to PI3K/AKT/mTOR inhibition. Supplementary Figure 2: AKT modulates sensitivity to ABT-737. Supplementary Figure 3: BEZ235/ABT-737 results in time-dependent ind…
View article: Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 85K
View article: Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 85K
View article: Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 579K, Supplemantary Figure 1: Bcl-2 and Bcl-xL determine sensitivity to PI3K/AKT/mTOR inhibition. Supplementary Figure 2: AKT modulates sensitivity to ABT-737. Supplementary Figure 3: BEZ235/ABT-737 results in time-dependent ind…
View article: Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 64K, Primary antibodies and cell lines generation
View article: Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism Open
PDF file - 54K, Mutations analysis in primary leukemia blasts.
View article: Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs
Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs Open
Basal-like triple-negative breast cancer (TNBC) tumor cells are difficult to eliminate due to resistance mechanisms that promote survival. While this breast cancer subtype has low PIK3CA mutation rates when compared to estrogen receptor-po…
View article: Acute megakaryoblastic leukemia with trisomy 3 and <i><scp>CBFA2T3</scp>::<scp>GLIS2</scp></i>: A case report
Acute megakaryoblastic leukemia with trisomy 3 and <i><span>CBFA2T3</span>::<span>GLIS2</span></i>: A case report Open
Non‐Down‐syndrome‐related acute megakaryoblastic leukemia (non‐DS‐AMKL) is a rare form of leukemia that can present with a variety of initial symptoms, including fever, rash, bruising, bleeding, or other more clinically challenging symptom…
View article: IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms
IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms Open
Interactions between the inhibitor of apoptosis protein antagonist LCL161 and the histone deacetylase inhibitor panobinostat (LBH589) were examined in human multiple myeloma (MM) cells. LCL161 and panobinostat interacted synergistically to…
View article: Development and Validation of Clinical Whole-Exome and Whole-Genome Sequencing for Detection of Germline Variants in Inherited Disease
Development and Validation of Clinical Whole-Exome and Whole-Genome Sequencing for Detection of Germline Variants in Inherited Disease Open
- with the decrease in the cost of sequencing, the clinical testing paradigm has shifted from single gene To gene panel and now whole-exome and whole-genome sequencing. clinical laboratories are rapidly implementing next-generation sequenc…
View article: Development and Validation of Targeted Next-Generation Sequencing Panels for Detection of Germline Variants in Inherited Diseases
Development and Validation of Targeted Next-Generation Sequencing Panels for Detection of Germline Variants in Inherited Diseases Open
- The number of targeted next-generation sequencing (NGS) panels for genetic diseases offered by clinical laboratories is rapidly increasing. Before an NGS-based test is implemented in a clinical laboratory, appropriate validation studies …
View article: Additional file 2 of New generation breast cancer cell lines developed from patient-derived xenografts
Additional file 2 of New generation breast cancer cell lines developed from patient-derived xenografts Open
Additional file 2: Supplementary Table 1. RNA-seq of UCD cell lines.
View article: Lynch syndrome–associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome
Lynch syndrome–associated ultra-hypermutated pediatric glioblastoma mimicking a constitutional mismatch repair deficiency syndrome Open
Pediatric glioblastoma multiforme (GBM) has a poor prognosis as a result of recurrence after treatment of surgery and radiochemotherapy. A small subset of pediatric GBMs presenting with an ultra-high tumor mutational burden (TMB) may be se…
View article: Precision oncogenomics
Precision oncogenomics Open
An open-access, peer-reviewed, international journal in the field of precision medicine. Articles in the journal present genomic and molecular analyses of individuals or cohorts alongside their clinical presentations and phenotypic informa…