Andrea Frontini
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View article: Fast Detection and Classification of Microplastics by a Wide-Field Fourier Transform Raman Microscope
Fast Detection and Classification of Microplastics by a Wide-Field Fourier Transform Raman Microscope Open
A number of applications require methods to detect with high spatial resolution and chemical specificity microplastics (MPs) extracted from different matrices. Here we introduce a wide-field hyperspectral Fourier transform Raman microscope…
View article: Novel Ti6Al4V Surface Treatment for Subperiosteal Dental Implants: Evaluation of Osteoblast-like Cell Proliferation and Osteogenic Response
Novel Ti6Al4V Surface Treatment for Subperiosteal Dental Implants: Evaluation of Osteoblast-like Cell Proliferation and Osteogenic Response Open
Nowadays, custom-made subperiosteal implants are emerging as a solution in all those cases where there is lack of healthy bone tissue to support endosseous implants. The development of innovative techniques has allowed the production of gr…
View article: Natural-based solutions to mitigate dietary microplastics side effects in fish
Natural-based solutions to mitigate dietary microplastics side effects in fish Open
Dietary microplastics (MPs) can be consumed by fish, crossing through the gastrointestinal tract. MPs smaller than 20 μm can easily translocate to other organs, such as liver, commonly triggering oxidative stress in fish. Given the current…
View article: Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance
Overexpression of Glyoxalase 2 in Human Breast Cancer Cells: Implications for Cell Proliferation and Doxorubicin Resistance Open
Glyoxalase 2 (Glo2) is an enzyme of the glyoxalase system whose pathway parallels glycolysis and which aims to remove methylglyoxal (MGO). This study analyzed the possible additional roles of the Glo2 enzyme in breast cancer (MCF7) and non…
View article: In Vitro Study of the Proliferation of MG63 Cells Cultured on Five Different Titanium Surfaces
In Vitro Study of the Proliferation of MG63 Cells Cultured on Five Different Titanium Surfaces Open
The use of dental implants for prosthetic rehabilitation in dentistry is based on the concept of osteointegration. This concept enables the clinical stability of the implants and a total absence of inflammatory tissue between the implant s…
View article: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis
Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis Open
The ΔTLQP-21 mouse line can be a valuable resource to conduct mechanistic studies on the necessary role of TLQP-21 in physiology and disease, while also serving as a platform to test the specificity of novel antibodies or immunoassays dire…
View article: Dietary Microplastic Administration during Zebrafish (Danio rerio) Development: A Comprehensive and Comparative Study between Larval and Juvenile Stages
Dietary Microplastic Administration during Zebrafish (Danio rerio) Development: A Comprehensive and Comparative Study between Larval and Juvenile Stages Open
One of the main sources of MPs contamination in fish farms is aquafeed. The present study investigated, for the first time through a comparative approach, the effects of different-sized fluorescent MPs included in a diet intended for zebra…
View article: HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia
HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia Open
The HtrA serine peptidase 1 (HTRA1) is a multidomain secretory protein with serine–protease activity involved in the regulation of many cellular processes in both physiological and pathological conditions. HTRA1 is normally expressed in th…
View article: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis
Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis Open
Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease. Genetic loss of function of a pro-peptide precursor results in the simultaneous …
View article: Reply to Mirabelli et al. Is Mesothelioma Unrelated to the Lung Asbestos Burden? Comment on “Visonà et al. Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples. Int. J. Environ. Res. Public Health 2021, 18, 2053”
Reply to Mirabelli et al. Is Mesothelioma Unrelated to the Lung Asbestos Burden? Comment on “Visonà et al. Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples. Int. J. Environ. Res. Public Health 2021, 18, 2053” Open
We appreciate very much the interest of Mirabelli et al. [...]
View article: Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples
Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples Open
Increased mortality due to malignant mesothelioma has been demonstrated by several epidemiologic studies in the area around Broni (a small town in Lombardy, northern Italy), where a factory producing asbestos cement was active between 1932…
View article: Optogenetic‐induced sympathetic neuromodulation of brown adipose tissue thermogenesis
Optogenetic‐induced sympathetic neuromodulation of brown adipose tissue thermogenesis Open
The brown adipose tissue (BAT) is a thermogenic organ that plays a major role in energy balance, obesity, and diabetes due to the potent glucose and lipid clearance that fuels its thermogenesis, which is largely mediated via sympathetic ne…
View article: Diagnosis of sudden cardiac death due to early myocardial ischemia: An ultrastructural and immunohistochemical study
Diagnosis of sudden cardiac death due to early myocardial ischemia: An ultrastructural and immunohistochemical study Open
The aim of this post-mortem ultrastructural and immunohistochemical study is to explore the characteristics of acute myocardial ischemia in the context of sudden death, using the combination of two different methods, both more insightful t…
View article: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression Open
MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication. MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only occasionally noted, however homozygosity for…
View article: Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract MFN2 encodes mitofusin 2, a m…
View article: Mammary alveolar epithelial cells convert to brown adipocytes in post‐lactating mice
Mammary alveolar epithelial cells convert to brown adipocytes in post‐lactating mice Open
During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary gland transdifferentiate reversibly to milk‐secreting epithelial cells. In this study, we demonstrate by transmission electron microscopy that in the post‐l…
View article: Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice
Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice Open
Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging…
View article: The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway
The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway Open
Brown adipose tissue (BAT) is essential for adaptive thermogenesis and dissipation of caloric excess through the activity of uncoupling protein (UCP)-1. BAT in humans is of great interest for the treatment of obesity and related diseases. …