Andrea Galmozzi
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View article: White and Brown Adipose Tissue Share a Common Fibro-Adipogenic Progenitor Population
White and Brown Adipose Tissue Share a Common Fibro-Adipogenic Progenitor Population Open
Adipose tissue heterogeneity has emerged as a central factor in regulating adipose tissue function in physiology and pathophysiology, yet tools to model and study this diversity in vitro remain limited. Here, we performed single-cell RNA s…
View article: Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response
Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response Open
Neuroinflammation is defined as a process that includes cellular responses designed to protect the central nervous system from external influences, and it initiates in cases of extreme deviations from homeostasis. While it serves a protect…
View article: 58 Single-cell comparative analysis reveals a similar regulatory subpopulation in white and brown adipocyte precursors
58 Single-cell comparative analysis reveals a similar regulatory subpopulation in white and brown adipocyte precursors Open
Objectives/Goals: The goal of this study is to resolve the complexity of the adipose precursor cells and identify potential therapeutic targets/mechanism to treat obesity, diabetes, cancer cachexia, and related metabolic conditions in both…
View article: Fast and deep phosphoproteome analysis with the Orbitrap Astral mass spectrometer
Fast and deep phosphoproteome analysis with the Orbitrap Astral mass spectrometer Open
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe the use of a nove…
View article: DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSE
DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSE Open
Neuroinflammation comprises biochemical and cellular responses of the nervous system to injury, emerging as a central process in many neurological conditions. Although beneficial in nature, over-activation of the immune response may result…
View article: Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue Open
With age, people tend to accumulate body fat and reduce energy expenditure 1 . Brown (BAT) and beige adipose tissue dissipate heat and increase energy expenditure via the activity of the uncoupling protein UCP1 and other thermogenic futile…
View article: Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer
Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer Open
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe the use of a nove…
View article: Deconstructing Adipose Tissue Heterogeneity One Cell at a Time
Deconstructing Adipose Tissue Heterogeneity One Cell at a Time Open
As a central coordinator of physiologic metabolism, adipose tissue has long been appreciated as a highly plastic organ that dynamically responds to environmental cues. Once thought of as a homogenous storage depot, recent advances have ena…
View article: Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity Open
In obesity, signaling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects. Overexpression of the IRE1-regulated transcription factor XBP1s in liver or fat protects against obesity-linked metabol…
View article: Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites
Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites Open
Metabolites that are dysregulated in a mouse model of inflammatory bowel disease are identified and characterized.
View article: Automated, miniaturized, and scalable screening of healthcare workers, first responders, and students for SARS-CoV-2 in San Diego County
Automated, miniaturized, and scalable screening of healthcare workers, first responders, and students for SARS-CoV-2 in San Diego County Open
Background Successful containment strategies for SARS-CoV-2, the causative virus of the COVID-19 pandemic, have involved widespread population testing that identifies infections early and enables rapid contact tracing. In this study, we de…
View article: Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice
Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice Open
The understanding of the mechanisms underlying adipocyte differentiation and function has greatly benefited from the use of immortalized white preadipocyte cell lines. These cultured cell lines, however, have limitations. They do not fully…
View article: Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity
Pharmacologic IRE1/XBP1s Activation Promotes Systemic Adaptive Remodeling in Obesity Open
In obesity, overexpression of the IRE1-regulated transcription factor XBP1s protects against metabolic dysfunction by stimulating adaptive remodeling of multiple tissues, most notably the liver. 1–5 This observation suggests that pharmacol…
View article: Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits
Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits Open
•A pure analog of hops isohumulones signals via the bitter taste receptor Tas2r108.•KDT501 stimulates endogenous GLP-1 secretion and enhances glucose tolerance.•Long-term KDT501 treatment reduces weight, dyslipidemia, and insulin resistanc…
View article: Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs Open
The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin condition actinic keratosis. IngMeb is proposed to exert its therapeutic effects thro…
View article: Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue Open
Arylfluorosulfates have appeared only rarely in the literature and have not been explored as probes for covalent conjugation to proteins, possibly because they were assumed to possess high reactivity, as with other sulfur(VI) halides. Howe…