Andrea Ganna
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View article: Genetic associations with educational fields
Genetic associations with educational fields Open
Educational field choices shape careers, wellbeing and the societal skill distribution, yet genetic influences on what people study remain poorly understood. Here we show that genetic factors are associated with educational field specializ…
View article: Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial
Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial Open
It is unclear whether the effectiveness of weight loss interventions differs based on genetic predisposition to higher body mass index (BMI). Genome-wide polygenic scores (PS) for BMI are the strongest genetic predictors of elevated body w…
View article: Federated Analysis of Cross-European Health Data: Improving CVD prediction with Machine Learning
Federated Analysis of Cross-European Health Data: Improving CVD prediction with Machine Learning Open
Background Federated analysis of nationwide health registers using machine learning could enhance cardiovascular disease (CVD) prediction. As a part of the HealthData@EU Pilot, the current study developed and validated CVD prediction model…
View article: Limited overlap between genetic effects on disease susceptibility and disease survival
Limited overlap between genetic effects on disease susceptibility and disease survival Open
Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with dis…
View article: Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model
Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model Open
The Evolve model seems promising at enabling continuous health monitoring, early disease detection, and retrospective analysis, making it a promising tool for personalized healthcare interventions. Code available at: https://github.com/han…
View article: The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases
The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases Open
Both socioeconomic circumstances and genetic predisposition shape disease risk, yet their joint contribution across diseases has not been systematically examined. We studied 19 high-burden diseases in 743,194 participants (729,928 European…
View article: Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores
Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores Open
Electronic health record (EHR)-based phenotype risk scores (PheRS) leverage individuals’ health trajectories to estimate disease risk, similar to how polygenic scores (PGS) use genetic information. While PGS generalizability has been studi…
View article: Heterogenous associations of polygenic indices of 35 traits with mortality
Heterogenous associations of polygenic indices of 35 traits with mortality Open
Background Polygenic indices (PGIs) of various traits abound, but the knowledge remains limited on how they predict wide-ranging health indicators, including the risk of death. We investigated the associations between mortality and 35 diff…
View article: Heterogenous associations of polygenic indices of 35 traits with mortality
Heterogenous associations of polygenic indices of 35 traits with mortality Open
Background Polygenic indices (PGIs) of various traits abound, but the knowledge remains limited on how they predict wide-ranging health indicators, including the risk of death. We investigated the associations between mortality and 35 diff…
View article: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression Open
View article: Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior Open
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 ind…
View article: Author Correction: Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Author Correction: Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design Open
View article: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression Open
View article: Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design Open
View article: 50,000 years of evolutionary history of India: Impact on health and disease variation
50,000 years of evolutionary history of India: Impact on health and disease variation Open
India has been underrepresented in genomic surveys. We generated whole-genome sequences from 2,762 individuals in India, capturing the genetic diversity across most geographic regions, linguistic groups, and historically underrepresented c…
View article: Genome-wide association study of long COVID
Genome-wide association study of long COVID Open
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result…
View article: Polygenic risk score prediction accuracy convergence
Polygenic risk score prediction accuracy convergence Open
View article: Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes Open
Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship …
View article: Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Open
View article: Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery Open
Obesity is a major public health challenge. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and bariatric surgery (BS) are effective weight loss interventions; however, the genetic factors influencing treatment response remain largely …
View article: Heterogenous associations of polygenic indices of 35 traits with mortality
Heterogenous associations of polygenic indices of 35 traits with mortality Open
Background Polygenic indices (PGIs) of various traits abound, but knowledge remains limited on how they predict wide-ranging health indicators, including the risk of death. We investigated the associations between mortality and 35 differen…
View article: Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood
Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood Open
View article: Large language models improve transferability of electronic health record-based predictions across countries and coding systems
Large language models improve transferability of electronic health record-based predictions across countries and coding systems Open
Variation in medical practices and reporting standards across healthcare systems limits the transferability of prediction models based on structured electronic health record (EHR) data. We introduce GRASP, a novel transformer-based archite…
View article: Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank
Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank Open
Sex chromosome trisomies (SCT) are the most common whole chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational studies of clinically diagnosed cases, res…
View article: Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model
Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model Open
Health registers contain rich information about individuals' health histories. Here our interest lies in understanding how individuals' health trajectories evolve in a nationwide longitudinal dataset with coded features, such as clinical c…
View article: High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene
High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene Open
View article: Integrating genetic data in target trial emulations improves their design and informs the value of polygenic scores for prognostic and predictive enrichment
Integrating genetic data in target trial emulations improves their design and informs the value of polygenic scores for prognostic and predictive enrichment Open
Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of medical interventions but ethical, practical, and financial limitations often necessitate decisions based on observational data. The increa…
View article: Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes
Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes Open
Low drug adherence is a major obstacle to the benefits of pharmacotherapies and it is therefore important to identify factors associated with discontinuing or being poorly adherent to a prescribed treatment regimen. Using high-quality nati…
View article: Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes Open
Clonal hematopoiesis (CH) becomes more prevalent with age and may impact the pathophysiology of inflammatory diseases by altering immune cell function. While clonal hematopoiesis of indeterminate potential (CHIP) can promote inflammation i…
View article: Transferability and accuracy of electronic health record-based predictors compared to polygenic scores
Transferability and accuracy of electronic health record-based predictors compared to polygenic scores Open
Electronic health record (EHR)-based phenotype risk scores (PheRS) leverage individuals’ health trajectories to infer disease risk. Similarly, polygenic scores (PGS) use genetic information to estimate disease risk. While PGS generalizabil…