Andrea Gompers
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View article: SPP1hi macrophages, NKG7 T cells, CCL5hi fibroblasts, and IgM plasma cells are dominant features of necrobiosis
SPP1hi macrophages, NKG7 T cells, CCL5hi fibroblasts, and IgM plasma cells are dominant features of necrobiosis Open
Necrobiosis is a histologic term used to describe abnormal deposits of "degenerating" collagen within the skin. It can be found as an incidental finding in various granulomatous conditions, but is a hallmark of necrobiosis lipoidica (NL) a…
View article: Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection Open
Background Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progress…
View article: Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection Open
Background : Immunosurveillance of the central nervous system (CNS) is vital to resolve infection and injury. However, immune activation within the CNS in the setting of chronic viral infections, such as HIV-1, is strongly linked to progre…
View article: Additional file 2 of Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
Additional file 2 of Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection Open
Additional file 2: Table S2. Normalized Read Counts. Normalized read counts in units of Log2 Counts per Million (CPM). Sample IDs are listed in row 1 and correspond to Code in Table S1. Corresponding Gene.stable.ID and Gene names are liste…
View article: Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice
Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice Open
Background Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the Na V 1.1 sodium channel alph…
View article: Additional file 6 of Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice
Additional file 6 of Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice Open
Additional file 6:. Table S5–11. Table S5. RPKM values for P7 samples. Table S6. RPKM values for P32 1b+/− samples. Table S7. RPKM values for P32 1b−/− samples. Table S8. Differentially expressed genes between WT and 1b+/− mice at P7. Tabl…
View article: Deletion of a non-canonical regulatory sequence causes loss of <i>Scn1a</i> expression and epileptic phenotypes in mice
Deletion of a non-canonical regulatory sequence causes loss of <i>Scn1a</i> expression and epileptic phenotypes in mice Open
Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the Na V 1.1 sodium channel alpha subunit, …
View article: Heterozygous mutation to<i>Chd8</i>causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse
Heterozygous mutation to<i>Chd8</i>causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse Open
Summary The chromatin remodeling gene CHD8 represents a central node in early neurodevelopmental gene networks implicated in autism. We examined the impact of heterozygous germline Chd8 mutation on neurodevelopment in mice. Network analysi…