Andréa Hemmerlin
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View article: Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification
Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification Open
Type-I protein prenylation, the post-translational modification of CaaX motif-containing proteins, relies on two substrates: the target protein and a mevalonate-derived prenyl diphosphate co-substrate, either farnesyl diphosphate (FPP) or …
View article: Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants
Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants Open
In plants, the plastidial mevalonate (MVA)-independent pathway is required for the modification with geranylgeranyl groups of CaaL-motif proteins, which are substrates of protein geranylgeranyltransferase type-I (PGGT-I). As a consequence,…
View article: Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants
Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants Open
The modification of GFP-CaaL sensor proteins by geranylgeranyl groups in plants requires an active plastidial mevalonate (MVA)-independent pathway. As a consequence, fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose (DX)-5 phosphate…
View article: Phosphorylation of Metabolites Involved in Salvage Pathways for Isoprenoid Biosynthesis in Plants
Phosphorylation of Metabolites Involved in Salvage Pathways for Isoprenoid Biosynthesis in Plants Open
The recycling of metabolic products is a major way to reduce the energy cost of de novo biosynthesis. The salvage pathways involved not only regain a metabolic product but also generate additional molecules that might serve specific physio…
View article: Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells
Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells Open
This work describes the reactivity and properties of fluorinated derivatives (F-PD and F-PDO) of plasmodione (PD) and its metabolite, the plasmodione oxide (PDO). Introduction of a fluorine atom on the 2-methyl …
View article: Unravelling the Puzzle of Anthranoid Metabolism in Living Plant Cells Using Spectral Imaging Coupled to Mass Spectrometry
Unravelling the Puzzle of Anthranoid Metabolism in Living Plant Cells Using Spectral Imaging Coupled to Mass Spectrometry Open
Vismione H (VH) is a fluorescent prenylated anthranoid produced by plants from the Hypericaceae family, with antiprotozoal activities against malaria and leishmaniosis. Little is known about its biosynthesis and metabolism in plants or its…
View article: Unravelling the puzzle of anthranoids metabolism in living plant cells using spectral imaging coupled to mass spectrometry
Unravelling the puzzle of anthranoids metabolism in living plant cells using spectral imaging coupled to mass spectrometry Open
Vismione H (VH) is a fluorescent prenylated anthranoid produced by plants from the Hypericaceae family, with antiprotozoal activities against malaria and leishmaniosis. Little is known about its biosynthesis and metabolism in plants or its…
View article: The specific molecular architecture of plant 3-hydroxy-3-methylglutaryl-CoA lyase
The specific molecular architecture of plant 3-hydroxy-3-methylglutaryl-CoA lyase Open
View article: Farnesol-mediated shift in the metabolic origin of prenyl groups used for protein prenylation in plants
Farnesol-mediated shift in the metabolic origin of prenyl groups used for protein prenylation in plants Open
View article: The potential of the mevalonate pathway for enhanced isoprenoid production
The potential of the mevalonate pathway for enhanced isoprenoid production Open
View article: Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation
Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation Open
In a preceding study we have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the …
View article: Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation
Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation Open
We have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable, carboxy-t…