Andrea Hsiu Ling Low
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View article: Autoimmune rheumatic diseases and manifestations for population screening: a consensus development study
Autoimmune rheumatic diseases and manifestations for population screening: a consensus development study Open
Introduction: Self-administered screening questionnaires are one of the key strategies to shorten diagnostic delay among patients with autoimmune rheumatic diseases (ARDs). However, most existing screening questionnaires for ARDs were deve…
View article: POS1040 CHARTING A NEW COURSE IN IDIOPATHIC INFLAMMATORY MYOPATHIES: RE-EXPLORING HOW RACE SHAPES ANTIBODIES AND SUBSETS IN ASIA AND PACIFIC
POS1040 CHARTING A NEW COURSE IN IDIOPATHIC INFLAMMATORY MYOPATHIES: RE-EXPLORING HOW RACE SHAPES ANTIBODIES AND SUBSETS IN ASIA AND PACIFIC Open
View article: ABS0098 UTILIZING HIGH-DIMENSIONAL MASS CYTOMETRY TO DECODE COMPLEX PERIPHERAL IMMUNE SIGNATURES IN PROGRESSIVE INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS WITH POTENTIAL THERAGNOSTIC APPLICATIONS
ABS0098 UTILIZING HIGH-DIMENSIONAL MASS CYTOMETRY TO DECODE COMPLEX PERIPHERAL IMMUNE SIGNATURES IN PROGRESSIVE INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS WITH POTENTIAL THERAGNOSTIC APPLICATIONS Open
View article: POS1110 POTENTIAL ROLE OF IMMUNOSUPPRESSION TO IMPROVE GASTROINTESTINAL MANIFESTATION IN SYSTEMIC SCLEROSIS
POS1110 POTENTIAL ROLE OF IMMUNOSUPPRESSION TO IMPROVE GASTROINTESTINAL MANIFESTATION IN SYSTEMIC SCLEROSIS Open
View article: Evidence from two rounds of Population HIV Impact Assessments of progress towards HIV epidemic control in adolescents aged 15–19 years in Eswatini, Lesotho, Malawi, and Zimbabwe: a cross-sectional study
Evidence from two rounds of Population HIV Impact Assessments of progress towards HIV epidemic control in adolescents aged 15–19 years in Eswatini, Lesotho, Malawi, and Zimbabwe: a cross-sectional study Open
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View article: A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study
A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study Open
Introduction: Systemic sclerosis is a rare autoimmune connective tissue disease characterised by (1) microvasculopathy; (2) immune dysregulation; and (3) progressive fibrosis of the skin and internal organs. Soluble guanylate cyclase plays…
View article: Predictive factors for interstitial lung disease progression in a Singapore systemic sclerosis cohort: a multicentre study
Predictive factors for interstitial lung disease progression in a Singapore systemic sclerosis cohort: a multicentre study Open
Introduction: Interstitial lung disease (ILD) in systemic sclerosis (SSc) is heterogeneous with varied progression rate. This study aimed to identify the baseline clinical characteristics associated with ILD progression within 1, 3 and 5 y…
View article: Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension in Singapore
Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension in Singapore Open
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by significant morbidity and mortality. Intravenous (IV) epoprostenol (Veletri, Johnson & Johnson, US), a prostacyclin analogue, has been shown to improve exercis…
View article: Predictive accuracy of the <scp>ASIG</scp> algorithm in a prospective systemic sclerosis cohort undergoing annual screening for pulmonary arterial hypertension
Predictive accuracy of the <span>ASIG</span> algorithm in a prospective systemic sclerosis cohort undergoing annual screening for pulmonary arterial hypertension Open
The Australian Scleroderma Interest Group (ASIG) algorithm for screening pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) requires only respiratory function tests and serum N‐terminal pro‐brain natriuretic peptide as first…
View article: Comparative Analysis of Single-Cell RNA Sequencing Methods with and without Sample Multiplexing
Comparative Analysis of Single-Cell RNA Sequencing Methods with and without Sample Multiplexing Open
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique for investigating biological heterogeneity at the single-cell level in human systems and model organisms. Recent advances in scRNA-seq have enabled the pooling of c…
View article: P144: Persistence of growth-promoting effects in children with achondroplasia up to 7 years: Update from phase 2 extension study with vosoritide*
P144: Persistence of growth-promoting effects in children with achondroplasia up to 7 years: Update from phase 2 extension study with vosoritide* Open
Vosoritide is approved for use in children with achondroplasia (ACH) on the basis of a pivotal phase 3 study which demonstrated significant improvements in annualized growth velocity (AGV) vs placebo. Long-term data are being collected in …
View article: Sustained Growth-Promoting Effects of Vosoritide in Children with Achondroplasia from an Ongoing Phase 3 Extension Study
Sustained Growth-Promoting Effects of Vosoritide in Children with Achondroplasia from an Ongoing Phase 3 Extension Study Open
View article: P131: Persistence of growth-promoting effects in infants and toddlers with achondroplasia: Results from a phase II extension study with vosoritide*
P131: Persistence of growth-promoting effects in infants and toddlers with achondroplasia: Results from a phase II extension study with vosoritide* Open
Vosoritide, a potent stimulator of endochondral bone growth, is approved for use in children with achondroplasia (ACH) until closure of epiphyses. We recently reported results from a phase 2, randomized, double-blind, placebo-controlled st…
View article: Validation of the OPTICS and H2FPEF risk scores for post-capillary pulmonary hypertension in an asian cohort
Validation of the OPTICS and H2FPEF risk scores for post-capillary pulmonary hypertension in an asian cohort Open
Background The differentiation between pre- and post-capillary pulmonary hypertension (PH) plays a significant impact in the management of PH patients. Right heart catheterization (RHC) serves as an important test to facilitate this differ…
View article: The Pathogenesis of Systemic Sclerosis: The Origin of Fibrosis and Interlink with Vasculopathy and Autoimmunity
The Pathogenesis of Systemic Sclerosis: The Origin of Fibrosis and Interlink with Vasculopathy and Autoimmunity Open
Systemic sclerosis (SSc) is an autoimmune disease associated with increased mortality and poor morbidity, impairing the quality of life in patients. Whilst we know that SSc affects multiple organs via vasculopathy, inflammation, and fibros…
View article: Recommendations for enhanced primary series (third dose) COVID-19 vaccination for people with rheumatic diseases: chapter of Rheumatologists, College of Physicians, Singapore
Recommendations for enhanced primary series (third dose) COVID-19 vaccination for people with rheumatic diseases: chapter of Rheumatologists, College of Physicians, Singapore Open
Introduction: This review aims to provide evidence-based recommendations for an enhanced primary series (third dose) coronavirus disease 2019 (COVID-19) vaccination in people with rheumatic diseases (PRDs) in the local and regional context…
View article: Comparative analysis of single-cell RNA sequencing methods with and without sample multiplexing
Comparative analysis of single-cell RNA sequencing methods with and without sample multiplexing Open
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique for investigating biological heterogeneity at the single-cell level in human systems and model organisms. Recent advances in scRNA-seq have enabled the pooling of c…
View article: POS0971 A COMPARISON OF MYOSITIS AUTOANTIBODY AND CLINICAL CHARACTERISTICS AMONG RACIAL GROUPS IN ASIA AND AUSTRALASIA – A COLLABORATIVE MULTICENTRE EFFORT BY THE APLAR MYOSITIS SIG
POS0971 A COMPARISON OF MYOSITIS AUTOANTIBODY AND CLINICAL CHARACTERISTICS AMONG RACIAL GROUPS IN ASIA AND AUSTRALASIA – A COLLABORATIVE MULTICENTRE EFFORT BY THE APLAR MYOSITIS SIG Open
View article: Outcomes of selexipag for treatment of pulmonary arterial hypertension in an Asian population
Outcomes of selexipag for treatment of pulmonary arterial hypertension in an Asian population Open
Dear Editor, Pulmonary arterial hypertension (PAH) is a progressive condition characterised by increased pulmonary arterial pressure and pulmonary vascular resistance, resulting in right ventricular dysfunction and eventually cardiac failu…
View article: Gut microbiome profiling in systemic sclerosis: a metagenomic approach
Gut microbiome profiling in systemic sclerosis: a metagenomic approach Open
Using metagenomic sequencing, our study further underlines distinct alterations in microbiota profiling among Asian SSc patients.
View article: Approaches to improving symptom appraisal: a systematic literature review
Approaches to improving symptom appraisal: a systematic literature review Open
Objectives Poor symptom appraisal (detection, interpretation and response to symptoms) plays a major role in prolonged prediagnosis interval in various health conditions. Theories and models have been proposed to study the symptom appraisa…
View article: Toward Molecular Stratification and Precision Medicine in Systemic Sclerosis
Toward Molecular Stratification and Precision Medicine in Systemic Sclerosis Open
Systemic sclerosis (SSc), a complex multi-systemic disease characterized by immune dysregulation, vasculopathy and fibrosis, is associated with high mortality. Its pathogenesis is only partially understood. The heterogenous pathological pr…
View article: Tocilizumab for systemic sclerosis with cardiac involvement: a case report
Tocilizumab for systemic sclerosis with cardiac involvement: a case report Open
View article: Systemic sclerosis in Asians: Are there racial differences?
Systemic sclerosis in Asians: Are there racial differences? Open
Systemic sclerosis is a multisystemic autoimmune disease characterized by vasculopathy and fibrosis. Racial factors exert a significant influence on the epidemiology, clinical manifestations, antibody profile, mortality and genetic factors…
View article: POS1411 EARLY IDENTIFICATION OF AXIAL SPONDYLOARTHRITIS IN A MULTI-ETHNIC ASIAN POPULATION
POS1411 EARLY IDENTIFICATION OF AXIAL SPONDYLOARTHRITIS IN A MULTI-ETHNIC ASIAN POPULATION Open
View article: Recommendations for COVID‐19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists
Recommendations for COVID‐19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists Open
Aim People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID‐19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS‐CoV‐2 in PRD. Methods Systematic literature …
View article: Recommendations for COVID-19 Vaccination in People with Rheumatic Disease:<i>Developed by the Singapore Chapter of Rheumatologists</i>
Recommendations for COVID-19 Vaccination in People with Rheumatic Disease:<i>Developed by the Singapore Chapter of Rheumatologists</i> Open
Aim People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID-19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS-CoV-2 in PRD. Methods Systematic literature …
View article: Are adolescent boys and young men being left behind? missing discourse and missed opportunities for engagement in HIV prevention in Eastern and Southern Africa
Are adolescent boys and young men being left behind? missing discourse and missed opportunities for engagement in HIV prevention in Eastern and Southern Africa Open
HIV prevention initiatives among young women aged 15–24 have become a focal point because of the extraordinarily high incidence of HIV in this group, especially compared to their male counterparts. This gender gap is especially pronounced …
View article: Work Productivity and Economic Burden of Systemic Sclerosis in a Multiethnic Asian Population
Work Productivity and Economic Burden of Systemic Sclerosis in a Multiethnic Asian Population Open
Objective To assess work productivity, identify associated factors and evaluate the economic burden of systemic sclerosis (SSc) in a multiethnic Asian population. Methods Data on employment status and work productivity loss were collected.…
View article: Evaluating the effectiveness of incentives to improve HIV prevention outcomes for young females in Eswatini: Sitakhela Likusasa impact evaluation protocol and baseline results
Evaluating the effectiveness of incentives to improve HIV prevention outcomes for young females in Eswatini: Sitakhela Likusasa impact evaluation protocol and baseline results Open