Andrea Irazoki
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View article: Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer
Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer Open
Cancer-associated cachexia is characterized by weight loss, muscle wasting, systemic inflammation, and functional decline. This multifactorial syndrome is highly prevalent and detrimental in patients with advanced-stage non–small cell lung…
View article: Activin receptor type IIA/IIB blockade increases muscle mass and strength, but compromises glycemic control in mice
Activin receptor type IIA/IIB blockade increases muscle mass and strength, but compromises glycemic control in mice Open
View article: Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice
Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice Open
Short abstract Purpose Blocking the Activin receptor type IIA and B (ActRIIA/IIB) has clinical potential to increase muscle mass and improve glycemic control in obesity, cancer, and aging. However, the impact of blocking ActRIIA/IIB on str…
View article: The Gut Microbial Metabolite Butyrate Alleviates IL‐1β‐Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets
The Gut Microbial Metabolite Butyrate Alleviates IL‐1β‐Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets Open
Butyrate, a gut microbiota‐derived metabolite, supports cellular health. In pancreatic beta cells, inflammation and oxidative stress disrupt mitochondrial function, contributing to dysfunction. This study explores how butyrate influences m…
View article: Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice
Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice Open
Background Cancer cachexia, affecting up to 80% of patients with cancer, is characterized by muscle and fat loss with functional decline. Preclinical research seeks to uncover the molecular mechanisms underlying cachexia to identify potent…
View article: The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms Open
View article: Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice
Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice Open
Summary Cancer cachexia is a metabolic condition affecting up to 80% of patients with cancer. Cachexia is mediated by reduced muscle and fat mass and impaired function, and it lowers survival for patients. With no approved drugs to treat c…
View article: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging Open
Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development…
View article: Mitochondrial fitness sustains healthy muscle aging
Mitochondrial fitness sustains healthy muscle aging Open
View article: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation Open
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial dynamics in mitigating such processes and their impact on mus…
View article: THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING
THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING Open
During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-rela…
View article: Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging Open
Sarcopenia is one of the main factors contributing to the disability of aged people. Among the possible molecular determinants of sarcopenia, increasing evidences suggest that chronic inflammation contributes to its development. However, a…
View article: Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway
Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway Open
Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF) contribute to normal heart development and function, and produce the post‐ischemic sc…
View article: A role for NCLX in NLRP3 inflammasome activation.
A role for NCLX in NLRP3 inflammasome activation. Open
View article: Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species
Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species Open
The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using in vivo and cell c…
View article: Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway Open