Andrea Maria Morace
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View article: Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes
Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes Open
Mild traumatic brain injury (mTBI) represents a significant public health concern, often resulting in long-term cognitive, emotional, and behavioral impairments. Despite its prevalence, effective therapeutic strategies for mitigating mTBI …
View article: Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes
Myrcene as a potential natural treatment in mild traumatic brain injury: Neurosensory changes Open
Mild traumatic brain injury (mTBI) represents a significant public health concern, often resulting in long-term cognitive, emotional, and behavioral impairments. Despite its prevalence, effective therapeutic strategies for mitigating mTBI …
View article: Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005)
Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005) Open
View article: The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation
The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation Open
Introduction Post-traumatic stress disorder (PTSD) is a chronic psychiatric condition characterized by persistent cognitive and affective disturbances following exposure to severe trauma. In rodents, prolonged post-weaning social isolation…
View article: Hydroxyl carboxylic acid receptor-2 (HCAR2) as a potential target in neurometabolic diseases
Hydroxyl carboxylic acid receptor-2 (HCAR2) as a potential target in neurometabolic diseases Open
Hydroxycarboxylic acid receptor 2 (HCAR2) is a G-protein-coupled receptor initially identified for its role in lipid metabolism. Beyond its classical metabolic functions, HCAR2 plays a pivotal role in chronic inflammatory diseases, neurome…
View article: Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms
Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms Open
Gut dysbiosis, characterized by an imbalance in the composition and function of microbiota, has emerged as a critical factor in the regulation of pain transmission and behavior through the gut–brain axis. When dysbiosis occurs, these regul…
View article: Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat
Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat Open
Background: The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM). Its actions on non-immune cells may also contribute to T1DM-associated complicatio…
View article: Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats
Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats Open
Cannabidiol has been shown to ameliorate neuropathic pain and its affective components. Previous studies highlighted the pharmacological interaction between the CBD and opioid system, particularly the MOR, but the understanding of the inte…
View article: Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia
Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia Open
Vulvodynia is a chronic pain condition that affects the vulvar area, often resulting in significant discomfort and a reduced quality of life. Current treatments for vulvodynia are limited, and there is a need for more effective therapeutic…
View article: Identification of Cannabidiolic and Cannabigerolic Acids as <scp>MTDL AChE</scp>, <scp>BuChE,</scp> and <scp>BACE</scp>‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
Identification of Cannabidiolic and Cannabigerolic Acids as <span>MTDL AChE</span>, <span>BuChE,</span> and <span>BACE</span>‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies Open
Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget‐directed ligands (MTDL) represent…
View article: Lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia
Lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia Open
View article: Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP
Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP Open
Transient global amnesia, both persistent and transient, is a very common neuropsychiatric syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test is the most widely used for transient global amnesia (TGA). Th…