Andrea Pallotta
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View article: Impact of rapid pathogen identification of gram-negative anaerobic bacteria from blood cultures on antimicrobial stewardship
Impact of rapid pathogen identification of gram-negative anaerobic bacteria from blood cultures on antimicrobial stewardship Open
Anaerobic bacteria are an important but understudied cause of bacteremia. The objective of this study was to evaluate the impact of using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to rapidl…
View article: P-1884. Evaluation of Outpatient Parenteral Antimicrobial Therapy Practices within a Large Healthcare System
P-1884. Evaluation of Outpatient Parenteral Antimicrobial Therapy Practices within a Large Healthcare System Open
Background The practice of outpatient parenteral antimicrobial therapy (OPAT) has challenges such as reduced control and monitoring in the outpatient setting. Lack of availability of OPAT lab monitoring is associated with poorer outcomes. …
View article: P-1459. Racial Disparities in Treatment of Community-Acquired Pneumonia in Hospitalized Patients
P-1459. Racial Disparities in Treatment of Community-Acquired Pneumonia in Hospitalized Patients Open
Background Community-acquired pneumonia (CAP) is a leading cause of hospitalizations and mortality in the US. Studies have reported racial disparities in various infectious syndromes, but race is not known to be associated with antimicrobi…
View article: P-638. Impact of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Nasal Screening on Antimicrobial De-escalation in Patients Admitted with Community-Acquired Pneumonia
P-638. Impact of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Nasal Screening on Antimicrobial De-escalation in Patients Admitted with Community-Acquired Pneumonia Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) is an important yet uncommon cause of inpatient community-acquired pneumonia (CAP). While the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) guideli…
View article: Acceptance of pharmacist-led stewardship recommendations for patients with community-acquired pneumonia
Acceptance of pharmacist-led stewardship recommendations for patients with community-acquired pneumonia Open
Background: Community-acquired pneumonia (CAP) is a leading cause of hospitalizations and mortality in the US. Overuse of extended spectrum antibiotics (ESA) for CAP contributes to antimicrobial resistance. The 2019 Infectious Diseases Soc…
View article: 2603. Acceptance of Pharmacist-Led Stewardship Recommendations for Patients with Community-Acquired Pneumonia
2603. Acceptance of Pharmacist-Led Stewardship Recommendations for Patients with Community-Acquired Pneumonia Open
Background Community-acquired pneumonia (CAP) is a leading cause of hospitalizations and mortality in the US. Overuse of extended spectrum antibiotics (ESA) for CAP contributes to antimicrobial resistance. The 2019 Infectious Diseases Soci…
View article: Evaluation of Dolutegravir- and Bictegravir-Based Antiretroviral Regimen Utilization in Patients who Cannot Take Medications by Mouth
Evaluation of Dolutegravir- and Bictegravir-Based Antiretroviral Regimen Utilization in Patients who Cannot Take Medications by Mouth Open
A retrospective review of patients unable to take medications by mouth showed short interruptions of therapy for most patients. In a secondary analysis, our data showed maintenance and/or achievement of viral suppression for most patients.…
View article: Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP)
Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP) Open
View article: Baricitinib versus tocilizumab in critically ill <scp>COVID</scp>‐19 patients: A retrospective cohort study
Baricitinib versus tocilizumab in critically ill <span>COVID</span>‐19 patients: A retrospective cohort study Open
Objectives The immunomodulators tocilizumab and baricitinib improve outcomes in severely ill patients with coronavirus disease 2019 (COVID‐19); however, comparative analyses of clinical outcomes related to these agents are lacking. A tocil…
View article: Intravenous to Oral Antibiotic Switch Therapy Among Patients Hospitalized With Community-Acquired Pneumonia
Intravenous to Oral Antibiotic Switch Therapy Among Patients Hospitalized With Community-Acquired Pneumonia Open
Background Community-acquired pneumonia (CAP) is a leading cause of hospital admissions and antimicrobial use. Clinical practice guidelines recommend switching from intravenous (IV) to oral antibiotics once patients are clinically stable. …
View article: Multidisciplinary Approach to Improve Human Immunodeficiency Virus and Syphilis Testing Rates in Emergency Departments
Multidisciplinary Approach to Improve Human Immunodeficiency Virus and Syphilis Testing Rates in Emergency Departments Open
Background Best practice guidelines recommend that patients at risk for sexually transmitted infections (STIs), such as gonorrhea (GC) and chlamydia, should also be tested for human immunodeficiency virus (HIV) and syphilis. This prospecti…
View article: 888. A Predictive Model for Subtherapeutic Vancomycin Troughs in Adults
888. A Predictive Model for Subtherapeutic Vancomycin Troughs in Adults Open
Background Vancomycin is a first line agent in the treatment of methicillin-resistant Staphylococcus aureus infections. The ability to predict sub-therapeutic troughs would limit potential for development of resistance. The purpose of this…
View article: Table of Contents
Table of Contents Open
View article: Monoclonal antibodies for treating COVID-19
Monoclonal antibodies for treating COVID-19 Open
Bamlanivimab and casirivimab-imdevimab are novel virus-neutralizing monoclonal antibodies authorized to treat mild to moderate COVID-19 in outpatients at risk for progression to severe disease. Treatment early in the disease may show effic…
View article: Multicenter point prevalence evaluation of the utilization and safety of drug therapies for COVID-19 at the onset of the pandemic timeline in the United States
Multicenter point prevalence evaluation of the utilization and safety of drug therapies for COVID-19 at the onset of the pandemic timeline in the United States Open
Key points In a multicenter point-prevalence study, we found that the rate of supportive care was high; among those receiving COVID-19 drug therapies, adverse reactions occurred in 12% of patients. Purpose There are currently no FDA-approv…
View article: Antimicrobial Stewardship Practice in the Ambulatory Setting From a National Cohort
Antimicrobial Stewardship Practice in the Ambulatory Setting From a National Cohort Open
Background The majority of antimicrobial use occurs in the ambulatory setting. Antimicrobial stewardship programs (ASPs) are effective in improving appropriate prescribing and are now required by accreditation bodies. Methods This was a cr…
View article: 39. Survey of Hepatitis B Vaccination Rates in Adult Patients with Diabetes at a Large Internal Medicine/Geriatrics Clinic
39. Survey of Hepatitis B Vaccination Rates in Adult Patients with Diabetes at a Large Internal Medicine/Geriatrics Clinic Open
Background The Advisory Committee on Immunization Practices (ACIP) recommends immunization with hepatitis B vaccine (HBV) for diabetic adults aged 19–59 years and advises HBV at the discretion of the treating clinician for those 60 years o…
View article: Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19
Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 Open
Background There are currently no FDA-approved medications for the treatment of COVID-19. At the onset of the pandemic, off-label medication use was supported by limited or no clinical data. We sought to characterize experimental COVID-19 …
View article: 1097. An Antimicrobial Stewardship Intervention to Optimize Cefazolin Dosing for Surgical Prophylaxis
1097. An Antimicrobial Stewardship Intervention to Optimize Cefazolin Dosing for Surgical Prophylaxis Open
Background Guidelines for antimicrobial prophylaxis in surgery recommend cefazolin dose be adjusted based on patient weight. Adults weighing ≥120 kg should receive a 3 g dose, all other adult patients should receive a 2 g dose pre-operativ…
View article: 2266. Management of Ertapenem-Resistant, Meropenem-Susceptible Enterobacteriaceae
2266. Management of Ertapenem-Resistant, Meropenem-Susceptible Enterobacteriaceae Open
Background Carbapenemases are the most frequent mechanism of carbapenem resistance in Enterobacteriaceae. However, alternative mechanisms such as loss of porin channels or up-regulation of efflux pumps can cause intermediate- to high-level…
View article: Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy
Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy Open
Simplifying or switching antiretroviral therapy (ART) in treatment-experienced people living with HIV (PLWH) may improve adherence, tolerability, toxicities, and/or drug–drug interactions. The purpose of this review is to critically evalua…
View article: 2484. Pre-Transplant Vaccination Adherence in Pediatric Solid Organ Transplant Patients at a Large Academic Medical Center
2484. Pre-Transplant Vaccination Adherence in Pediatric Solid Organ Transplant Patients at a Large Academic Medical Center Open
BACKGROUND: Adherence rates for recommended pre-transplant (pre-txp) vaccinations in pediatric solid-organ transplant (SOT) patients are variable and practice-dependent. Cleveland Clinic Children’s Hospital (CCCH) pre-txp adherence rates f…
View article: Validation and Evaluation of Antimicrobial Orders Indication for Use
Validation and Evaluation of Antimicrobial Orders Indication for Use Open
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View article: Evaluation of Antimicrobial Stewardship–Related Alerts Using a Clinical Decision Support System
Evaluation of Antimicrobial Stewardship–Related Alerts Using a Clinical Decision Support System Open
Background: Information technology, including clinical decision support systems (CDSS), have an increasingly important and growing role in identifying opportunities for antimicrobial stewardship–related interventions. Objective: The aim of…
View article: Adherence to Vaccination Guidelines in Patients Awaiting Kidney or Kidney–Pancreas Transplant
Adherence to Vaccination Guidelines in Patients Awaiting Kidney or Kidney–Pancreas Transplant Open
Vaccines are a component of preventative medicine; however, low vaccination rates in the organ transplant population are concerning due to increased risk of morbidity caused by common, preventable infections. Pre-transplant vaccination rat…
View article: Validation and Evaluation of Antimicrobial Orders Indication for Use
Validation and Evaluation of Antimicrobial Orders Indication for Use Open
Documenting indication for antimicrobial use is a best practice and stewardship initiative recommended by the CDC. On September 20, 2016, a mandatory selection of antimicrobial indication as empiric, pathogen-directed, or prophylaxis was i…
View article: Internally Developed Antimicrobial Use Benchmarking at a Large Academic Medical Center and Integrated Health System
Internally Developed Antimicrobial Use Benchmarking at a Large Academic Medical Center and Integrated Health System Open
View article: Early Experience With Ceftazidime/Avibactam at an Academic Medical Center and Affiliated Health System
Early Experience With Ceftazidime/Avibactam at an Academic Medical Center and Affiliated Health System Open
View article: Clinical Experience With Ceftolozane/Tazobactam at a Large Academic Medical Center
Clinical Experience With Ceftolozane/Tazobactam at a Large Academic Medical Center Open
View article: En Bloc Multivisceral and Kidney Transplantation in an HIV Patient: First Case Report
En Bloc Multivisceral and Kidney Transplantation in an HIV Patient: First Case Report Open