Andrea Schlotterer
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View article: Sex differences in the development of experimental diabetic retinopathy
Sex differences in the development of experimental diabetic retinopathy Open
This study aimed to characterize the role of female sex in the pathogenesis of diabetic retinopathy. In the retinae of female Ins2Akita -diabetic mice (F-IA), ovariectomized female Ins2Akita -diabetic mice (F-IA/OVX), male Ins2Akita -diabe…
View article: The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy
The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy Open
Aims Glucagon-like peptide-1 receptor agonists are effective treatments for type 2 diabetes, effectively lowering glucose without weight gain and with low risk for hypoglycemia. However, their influence on the retinal neurovascular unit re…
View article: miRNA-124 Prevents Rat Diabetic Retinopathy by Inhibiting the Microglial Inflammatory Response
miRNA-124 Prevents Rat Diabetic Retinopathy by Inhibiting the Microglial Inflammatory Response Open
Diabetic retinopathy (DR) is characterized by vasoregression and glial activation. miRNA-124 (miR-124) reduces retinal microglial activation and alleviates vasoregression in a neurodegenerative rat model. Our aim was to determine whether m…
View article: Protective Effects of Transient Glucose Exposure in Adult C. elegans
Protective Effects of Transient Glucose Exposure in Adult C. elegans Open
C. elegans are used to study molecular pathways, linking high glucose levels (HG) to diabetic complications. Persistent exposure of C. elegans to a HG environment induces the mitochondrial formation of reactive oxygen species (ROS) and adv…
View article: The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136
The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136 Open
These data, together with published findings that elevated MG leads to hyperglycemia, suggest the existence of a deleterious positive feedback loop whereby hyperglycemia leads to reduced Glo1 activity, contributing to elevated MG levels, w…
View article: MicroRNA-124 Alleviates Retinal Vasoregression via Regulating Microglial Polarization
MicroRNA-124 Alleviates Retinal Vasoregression via Regulating Microglial Polarization Open
Microglial activation is implicated in retinal vasoregression of the neurodegenerative ciliopathy-associated disease rat model (i.e., the polycystic kidney disease (PKD) model). microRNA can regulate microglial activation and vascular func…
View article: Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload Open
Taken together, our data show that iron causes the worsening of symptoms associated with the MetS and T2DM. These findings imply that iron depletion strategies together with anti-diabetic drugs may ameliorate IR and diabetic late complicat…
View article: Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease
Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease Open
Rationale: Vasoregression secondary to glial activation develops in various retinal diseases, including retinal degeneration and diabetic retinopathy. Photoreceptor degeneration and subsequent retinal vasoregression, characterized by peric…
View article: Plate-based Large-scale Cultivation of <em>Caenorhabditis elegans</em>: Sample Preparation for the Study of Metabolic Alterations in Diabetes
Plate-based Large-scale Cultivation of <em>Caenorhabditis elegans</em>: Sample Preparation for the Study of Metabolic Alterations in Diabetes Open
Culturing Caenorhabditis elegans (C. elegans) in a large-scale manner on agar plates can be time-consuming and difficult. This protocol describes a simple and inexpensive method to obtain a large number of animals for the isolation of prot…
View article: Neuronal damage and shortening of lifespan in C.�elegans by peritoneal dialysis fluid: Protection by glyoxalase‑1
Neuronal damage and shortening of lifespan in C.�elegans by peritoneal dialysis fluid: Protection by glyoxalase‑1 Open
Glucose and glucose degradation products (GDPs), contained in peritoneal dialysis (PD) fluids, contribute to the formation of advanced glycation end-products (AGEs). Local damaging effects, resulting in functional impairment of the periton…
View article: High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans Open
The enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. It metabolizes 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), which is an AMP analogue, leading to activation of AM…
View article: The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy
The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy Open
Our data suggest that linagliptin has a protective effect on the microvasculature of the diabetic retina, most likely due to a combination of neuroprotective and antioxidative effects of linagliptin on the neurovascular unit.