Andrea Vecchiola
YOU?
Author Swipe
View article: Novel nonsteroidal inhibitors of the human 11-beta hydroxysteroid dehydrogenase type 1 enzyme for the treatment of obesity and metabolic syndrome
Novel nonsteroidal inhibitors of the human 11-beta hydroxysteroid dehydrogenase type 1 enzyme for the treatment of obesity and metabolic syndrome Open
Nontumoral cortisol dysregulation in obese individuals is associated with many facets of metabolic syndrome, including central adiposity, diabetes mellitus (T2DM), dyslipidemia, and hypertension. Glucocorticoid availability and function at…
View article: Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis
Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis Open
During pregnancy, TPOAbs were dose-dependently associated with TSH, FT4, and the risk of abnormal thyroid function. With concentrations below currently used positivity cut-offs, TPOAbs could be associated with lower maternal thyroid functi…
View article: Adipocyte Extracellular Vesicles (Adevs) Promote a Proinflammatory and Profibrotic Profile in Human Renal and Endothelial Cells in Vitro
Adipocyte Extracellular Vesicles (Adevs) Promote a Proinflammatory and Profibrotic Profile in Human Renal and Endothelial Cells in Vitro Open
In obesity,white adipose tissue (WAT) undergoes hypertrophic and hyperplastic changes that are driven by phenotypical changes in preadipocytes and adipocytes. WAT also causes a chronic inflammatory state that modifies gene expression and t…
View article: Primary Aldosteronism in a Hispanic Cohort: Responses to Mineralocorticoid Receptor Antagonism and Remission in a Case
Primary Aldosteronism in a Hispanic Cohort: Responses to Mineralocorticoid Receptor Antagonism and Remission in a Case Open
Primary aldosteronism (PA) is the main cause of secondary arterial hypertension. In this study, we present the medical treatment of Hispanic patients with PA followed for up to 5 years, highlighting the complete cure with pharmacological t…
View article: Adipose Tissue Dysfunction and the Role of Adipocyte-Derived Extracellular Vesicles in Obesity and Metabolic Syndrome
Adipose Tissue Dysfunction and the Role of Adipocyte-Derived Extracellular Vesicles in Obesity and Metabolic Syndrome Open
Obesity is a major public health issue that is associated with metabolic diseases including diabetes mellitus type 2 and metabolic syndrome. This pathology leads to detrimental cardiovascular health and secondary effects, such as lipotoxic…
View article: The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor
The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor Open
Blood pressure (BP) regulation is a complex process involving various hormones, including aldosterone and its mineralocorticoid receptor. Mineralocorticoid receptor is expressed in several tissues, including the kidney, and plays a crucial…
View article: SAT651 Human Adipose-derived Extracellular Vesicles (AdEVs) Increase Proinflammatory Markers In Renal And Endothelial Cells: An In Vitro Preliminary Study
SAT651 Human Adipose-derived Extracellular Vesicles (AdEVs) Increase Proinflammatory Markers In Renal And Endothelial Cells: An In Vitro Preliminary Study Open
Disclosure: C.A. Carvajal: None. M.P. Hernandez: None. P. Carrion: None. A. Tapia: None. J.A. Lopez: None. A. Vecchiola: None. C.E. Fardella: None. A. Sandoval-Borquez: None. During obesity, white adipose tissue (WAT), undergoes hypertroph…
View article: Testosterona inhibe la actividad de la aldosterona sintasa silvestre y quimérica in vitro
Testosterona inhibe la actividad de la aldosterona sintasa silvestre y quimérica in vitro Open
The inhibitory effect of testosterone on ASWT or ASCE enzymes is a novel non-genomic testosterone action, suggesting that further clinical studies are needed to assess the role of testosterone in the screening and diagnosis of primary aldo…
View article: Plasminogen Activator Inhibitor-1 and Adiponectin Are Associated With Metabolic Syndrome Components
Plasminogen Activator Inhibitor-1 and Adiponectin Are Associated With Metabolic Syndrome Components Open
BACKGROUND We aimed to study the associations of adipocytokines, endothelial damage markers, and high-sensitivity C-reactive protein (hs-CRP) with metabolic syndrome (MetS) components. METHODS This cross-sectional study included 202 subjec…
View article: Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess Open
Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum co…
View article: Relationship Between Metabolic Syndrome Components and Proinflammatory Molecules
Relationship Between Metabolic Syndrome Components and Proinflammatory Molecules Open
We aimed to study the associations of 5 adipocytokines, two endothelial damage markers, and hs-CRP with the MetS components to distinguish the most significant cytokines likely related to distinct metabolic profiles. Methods: Cross-section…
View article: Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism
Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism Open
Context Primary aldosteronism (PA) represents 6% to 10% of all essential hypertension patients and is diagnosed using the aldosterone-to-renin ratio (ARR) and confirmatory studies. The complexity of PA diagnosis encourages the identificati…
View article: Novel Metabolomic Profile of Subjects with Non-classic Apparent Mineralocorticoid Excess
Novel Metabolomic Profile of Subjects with Non-classic Apparent Mineralocorticoid Excess Open
Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum co…
View article: Testosterone inhibits human wild-type and chimeric aldosterone synthase activity in vitro
Testosterone inhibits human wild-type and chimeric aldosterone synthase activity in vitro Open
BackgroundFamilial hyperaldosteronism type I is caused by the generation of a chimeric aldosterone synthase enzyme (ASCE) which is regulated by ACTH instead of angiotensin II. We have reported that in vitro, the wild-type (ASWT) and chimer…
View article: Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division Open
Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study e…
View article: SAT-590 Role of Adipocyte Hyperplasia and Hypertrophy in the Release and Charge of Exosomes in Human Fat Cells
SAT-590 Role of Adipocyte Hyperplasia and Hypertrophy in the Release and Charge of Exosomes in Human Fat Cells Open
In obesity, the increase in the number and / or size of adipocytes leads to chronic low-grade systemic inflammation that conditions the development and evolution of a series of pathologies such as coronary heart disease or cancer. The chan…
View article: Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome Open
Context Arterial hypertension (AHT) is one of the most frequent pathologies in the general population. Subtypes of essential hypertension characterized by low renin levels allowed the identification of 2 different clinical entities: aldost…
View article: Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess Open
View article: SAT-055 The Aldosterone-Renin Ratio Predicts Cardiometabolic Disorders in Subjects without Classic Primary Aldosteronism
SAT-055 The Aldosterone-Renin Ratio Predicts Cardiometabolic Disorders in Subjects without Classic Primary Aldosteronism Open
Background: Aldosterone has been linked with obesity, metabolic syndrome (MetS), pro-inflammatory and pro-thrombotic states. However, most of these studies relate to patients with evident primary aldosteronism (PA). Objective: To determine…
View article: SAT-LB012 Differential miRNA-Transcriptomic and Proteomic Profile in Urinary Exosomes of Subjects with "Nonclassic" Apparent Mineralocorticoid Excess Syndrome
SAT-LB012 Differential miRNA-Transcriptomic and Proteomic Profile in Urinary Exosomes of Subjects with "Nonclassic" Apparent Mineralocorticoid Excess Syndrome Open
Mineralocorticoid arterial hypertension has risen as one of the most prevalent causes of secondary hypertension, where 11β-hydroxysteroid dehydrogenase type-2 partial deficiency (also known as non-classical AME (NC-AME)), could reach a pre…
View article: Clinical, Biochemical, and Genetic Characteristics of “Nonclassic” Apparent Mineralocorticoid Excess Syndrome
Clinical, Biochemical, and Genetic Characteristics of “Nonclassic” Apparent Mineralocorticoid Excess Syndrome Open
These findings suggest a spectrum of partial 11β-HSD2 insufficiency in a primary care cohort without the classic phenotype and genotype of AME. NC-AME may represent a phenotype of MR activation and cardiovascular risk, suggesting that thes…
View article: Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation Open
BACKGROUND Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, and oxidative stress…
View article: Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency
Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Open
BACKGROUND Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We …
View article: Testosterone inhibits Human Wild-Type and Chimeric Aldosterone Synthase Activity In-vitro
Testosterone inhibits Human Wild-Type and Chimeric Aldosterone Synthase Activity In-vitro Open
We have recently reported that in vitro, the wild-type (ASWT) and chimeric aldosterone synthase (ASCE) enzymes are inhibited by progesterone and estradiol had no effect. To explore the direct action of testosterone on wild-type and chimeri…
View article: Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension Open
We report that MMP-9 activity and the cortisol/cortisone ratio were higher in pediatric primary hypertensive patients, and these associations were independent of the effect of obesity. The potential role of these novel biomarkers in predic…
View article: Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension
Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension Open
Arterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes. Specifically,…
View article: Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults
Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults Open
Our results showed that average sodium intake was higher than recommended in both children and adults (WHO ≤2,000mg/d). The sodium intake estimated by dietary assessment correlated with urinary excretion in all subjects, but in obese adult…
View article: Adrenal dysregulation in children who were born extremely premature - a pilot study
Adrenal dysregulation in children who were born extremely premature - a pilot study Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Aldosterone Production and Signaling Dysregulation in Obesity
Aldosterone Production and Signaling Dysregulation in Obesity Open
View article: Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children Open
The CA-repeat length did not influence BP levels or serum F/E ratios in pediatric subjects. However, the serum F/E ratio was associated with BP, suggesting a role of 11βHSD2 in mineralocorticoid hypertension.