Andrea Zhou
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View article: Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia.
Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia. Open
BACKGROUND: Preventing and treating post-acute sequelae of COVID-19 infection (PASC), commonly known as Long COVID, has become a public health priority. This study tests whether Paxlovid treatment in the acute phase of COVID-19 could help …
View article: Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia
Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia Open
Background Preventing and treating post-acute sequelae of COVID-19 infection (PASC), commonly known as Long COVID, has become a public health priority. This study tests whether Paxlovid treatment in the acute phase of COVID-19 could help p…
View article: A Bayesian Survival Analysis on Long COVID and Non-Long COVID Patients: A Cohort Study Using National COVID Cohort Collaborative (N3C) Data
A Bayesian Survival Analysis on Long COVID and Non-Long COVID Patients: A Cohort Study Using National COVID Cohort Collaborative (N3C) Data Open
Since the outbreak of the COVID-19 pandemic in 2020, numerous studies have focused on the long-term effects of COVID infection. On 1 October 2021, the Centers for Disease Control (CDC) implemented a new code in the International Classifica…
View article: Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US
Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US Open
Importance Understanding whether there are racial and ethnic and residential disparities in prenatal telehealth uptake is necessary for ensuring equitable access and guiding implementation of future hybrid (ie, both telehealth and in-perso…
View article: Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs
Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs Open
Post-Acute Sequelae of SARS-CoV-2 infection (PASC), also known as Long-COVID, encompasses a variety of complex and varied outcomes following COVID-19 infection that are still poorly understood. We clustered over 600 million condition diagn…
View article: Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs
Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs Open
View article: Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative
Tree-based classification model for Long-COVID infection prediction with age stratification using data from the National COVID Cohort Collaborative Open
Objectives We propose and validate a domain knowledge-driven classification model for diagnosing post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID, using Electronic Health Records (EHRs) data. Materials and Metho…
View article: Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID
Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID Open
View article: Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study
Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study Open
Background Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Chronic…
View article: Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID
Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID Open
View article: Leveraging multi-site electronic health data for characterization of subtypes: a pilot study of dementia in the N3C Clinical Tenant
Leveraging multi-site electronic health data for characterization of subtypes: a pilot study of dementia in the N3C Clinical Tenant Open
Objectives To provide a foundational methodology for differentiating comorbidity patterns in subphenotypes through investigation of a multi-site dementia patient dataset. Materials and Methods Employing the National Clinical Cohort Collabo…
View article: A Bayesian Survival Analysis on Long COVID and non Long COVID patients: A Cohort Study Using National COVID Cohort Collaborative (N3C) Data
A Bayesian Survival Analysis on Long COVID and non Long COVID patients: A Cohort Study Using National COVID Cohort Collaborative (N3C) Data Open
Since the outbreak of COVID-19 pandemic in 2020, numerous researches and studies have focused on the long-term effects of COVID infection. The Centers for Disease Control (CDC) implemented an additional code into the International Classifi…
View article: Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative Open
Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC).We assessed the impact of preexi…
View article: Effect of Paxlovid Treatment During Acute Covid-19 on Long Covid Onset: An EHR-Based Target Trial Emulation from the N3C and RECOVER Consortia
Effect of Paxlovid Treatment During Acute Covid-19 on Long Covid Onset: An EHR-Based Target Trial Emulation from the N3C and RECOVER Consortia Open
Background Preventing and treating post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID, has become a public health priority. Researchers have begun to explore whether Paxlovid treatment in the acute phase of CO…
View article: Characterizing the impact of SARS-CoV-2 reinfection on surgical outcomes
Characterizing the impact of SARS-CoV-2 reinfection on surgical outcomes Open
The COVID-19 pandemic has changed the delivery of surgical care.Early in the pandemic, an association between SARS-CoV-2 infection and adverse postoperative outcomes prompted the implementation of risk mitigation strategies, including rout…
View article: Outcomes of patients with active cancers and pre-existing cardiovascular diseases infected with SARS-CoV-2
Outcomes of patients with active cancers and pre-existing cardiovascular diseases infected with SARS-CoV-2 Open
View article: Nonelective coronary artery bypass graft outcomes are adversely impacted by Coronavirus disease 2019 infection, but not altered processes of care: A National COVID Cohort Collaborative and National Surgery Quality Improvement Program analysis
Nonelective coronary artery bypass graft outcomes are adversely impacted by Coronavirus disease 2019 infection, but not altered processes of care: A National COVID Cohort Collaborative and National Surgery Quality Improvement Program analysis Open
Traditional care processes were altered during the COVID-19 pandemic. Our data show that nonelective CABG in patients with active COVID-19 is associated with significantly increased rates of mortality and pneumonia. The equivalent mortalit…
View article: Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C)
Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C) Open
Objectives To define pregnancy episodes and estimate gestational age within electronic health record (EHR) data from the National COVID Cohort Collaborative (N3C). Materials and Methods We developed a comprehensive approach, named Hierarch…
View article: Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program
Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program Open
Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVI…
View article: Investigating the Impact of Temporal Labeling of Emergency Department Visits for COVID-19: Comparing Healthcare Disparities Analyses Using Comprehensive, Single-Site Data with National COVID Cohort Collaborative (N3C) Data
Investigating the Impact of Temporal Labeling of Emergency Department Visits for COVID-19: Comparing Healthcare Disparities Analyses Using Comprehensive, Single-Site Data with National COVID Cohort Collaborative (N3C) Data Open
National COVID Cohort Collaborative (N3C) en- clave provides health researchers with a rich dataset from 76 contributing clinical sites. However, the harmonized data lacks certain details available in sites’ local electronic health records…
View article: National Trends in Anticoagulation Therapy for COVID-19 Hospitalized Adults in the United States: Analyses of the National COVID Cohort Collaborative
National Trends in Anticoagulation Therapy for COVID-19 Hospitalized Adults in the United States: Analyses of the National COVID Cohort Collaborative Open
Background Anticoagulation (AC) utilization patterns and their predictors among hospitalized coronavirus disease 2019 (COVID-19) patients have not been well described. Methods Using the National COVID Cohort Collaborative, we conducted a r…
View article: Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program
Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program Open
View article: Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative Open
Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods We ass…
View article: Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population
Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population Open
View article: Risk for stillbirth among pregnant individuals with SARS-CoV-2 infection varied by gestational age
Risk for stillbirth among pregnant individuals with SARS-CoV-2 infection varied by gestational age Open
View article: SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study Open
Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of…
View article: Vaccination Against SARS-CoV-2 Decreases Risk of Adverse Events in Patients who Develop COVID-19 Following Cancer Surgery
Vaccination Against SARS-CoV-2 Decreases Risk of Adverse Events in Patients who Develop COVID-19 Following Cancer Surgery Open
View article: Long COVID Risk and Pre-COVID Vaccination: An EHR-Based Cohort Study from the RECOVER Program
Long COVID Risk and Pre-COVID Vaccination: An EHR-Based Cohort Study from the RECOVER Program Open
Importance Characterizing the effect of vaccination on long COVID allows for better healthcare recommendations. Objective To determine if, and to what degree, vaccination prior to COVID-19 is associated with eventual long COVID onset, amon…
View article: <i>In vivo</i> liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
<i>In vivo</i> liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects Open
Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dua…