Andreana P. Haley
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View article: Hidden risk: Latent cognitive profiles and structural brain age reveal vulnerability in midlife metabolic syndrome
Hidden risk: Latent cognitive profiles and structural brain age reveal vulnerability in midlife metabolic syndrome Open
Objective: Metabolic syndrome (MetS) is linked to later-life cognitive decline and brain aging, but early detection of vulnerability in midlife remains challenging. This study applied two methods to detect subtle changes in midlife adults …
View article: Predicting Metabolic Syndrome Risk through Environmental, Sleep, and Physical Activity Factors: The FEASible Study Protocol (Preprint)
Predicting Metabolic Syndrome Risk through Environmental, Sleep, and Physical Activity Factors: The FEASible Study Protocol (Preprint) Open
UNSTRUCTURED FEASible is a cross-sectional observational study that explores women’s daily living patterns through wearable devices and home environment sensors to validate the use of physical activity and indoor air quality data as indic…
View article: Assessing Associations between Environmental, Sleep, and Physical Activity Factors and Metabolic Syndrome Risk: The FEASible Study Protocol (Preprint)
Assessing Associations between Environmental, Sleep, and Physical Activity Factors and Metabolic Syndrome Risk: The FEASible Study Protocol (Preprint) Open
View article: Low carbohydrate and low-calorie diets reduce liver fat and lower brain glutamate and myo-inositol levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Low carbohydrate and low-calorie diets reduce liver fat and lower brain glutamate and myo-inositol levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open
In a longitudinal cohort study with intervention (NCT05216796), we utilized multiorgan imaging to determine if metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with elevated cerebral glutamate and myo-inositol…
View article: Dietary Saturated Fat Intake Moderates the Effect of Plasma Triglycerides on Memory Performance in Middle-Aged Adults
Dietary Saturated Fat Intake Moderates the Effect of Plasma Triglycerides on Memory Performance in Middle-Aged Adults Open
View article: Brainstem Volume and White Matter Characteristics Associated with Cognitive Performance in Healthy Middle‐aged Adults
Brainstem Volume and White Matter Characteristics Associated with Cognitive Performance in Healthy Middle‐aged Adults Open
Background Traditionally linked to essential physiological functions, the brainstem is now acknowledged for its role in cognition and dementia. Abnormal tau protein accumulation starts in the brainstem. Late life brainstem volume at baseli…
View article: Do mindfulness interventions cause harm? Findings from the Learning to Apply Mindfulness to Pain (LAMP) Pragmatic Clinical Trial
Do mindfulness interventions cause harm? Findings from the Learning to Apply Mindfulness to Pain (LAMP) Pragmatic Clinical Trial Open
Background Although mindfulness-based interventions (MBIs) are widely used in clinical and nonclinical settings, there has been little systematic study of their potential risks. To address this gap, we examined differences in psychological…
View article: Structural and functional sex differences in medial temporal lobe subregions at midlife
Structural and functional sex differences in medial temporal lobe subregions at midlife Open
View article: Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife
Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife Open
Introduction: Large neutral amino acids (LNAAs) tryptophan and phenylalanine have been implicated in the pathogenesis of neurodegenerative diseases. Given limited research on the effects of LNAA on brain health across different life stages…
View article: Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities
Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities Open
View article: Association between Large Neutral Amino Acids and Brain Integrity in Middle-Aged Adults at Metabolic Risk
Association between Large Neutral Amino Acids and Brain Integrity in Middle-Aged Adults at Metabolic Risk Open
This investigation delves into the interplay between large neutral amino acids (LNAA) and metabolic syndrome (MetS) in midlife adults, examining their collective influence on brain structure and cognitive function. While LNAA, such as tryp…
View article: Large Neutral Amino Acids Moderate the Effects of Metabolic Syndrome on Cognitive Performance in Middle-Aged Adults
Large Neutral Amino Acids Moderate the Effects of Metabolic Syndrome on Cognitive Performance in Middle-Aged Adults Open
Introduction: Two large neutral amino acids (LNAA), tryptophan and tyrosine, are precursors to cerebral neurotransmitters and are involved in cognitive function. Higher levels of LNAA in young adults are associated with impro…
View article: Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD
Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD Open
Background Although Black and Hispanic/Latino older adults are at increased risk for Alzheimer’s disease (AD), there is considerable within‐group heterogeneity in psychosocial factors of risk and resiliency amongst these community members.…
View article: Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities
Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities Open
Age and depression may interact to produce a “double jeopardy” for cognitive impairment, and executive functioning, in cognitively unimpaired aging. Few studies have considered middle age or the ethnoracial diversity of subjects, despite e…
View article: Empirically derived psychosocial‐behavioral phenotypes in Black/African American and Hispanic/Latino older adults enrolled in HABS‐HD: Associations with AD biomarkers and cognitive outcomes
Empirically derived psychosocial‐behavioral phenotypes in Black/African American and Hispanic/Latino older adults enrolled in HABS‐HD: Associations with AD biomarkers and cognitive outcomes Open
INTRODUCTION Identification of psychosocial‐behavioral phenotypes to understand within‐group heterogeneity in risk and resiliency to Alzheimer's disease (AD) within Black/African American and Hispanic/Latino older adults is essential for t…
View article: 6 Kynurenine/Tryptophan Ratio Moderates the Relationship Between Adiposity and Verbal Memory in Midlife
6 Kynurenine/Tryptophan Ratio Moderates the Relationship Between Adiposity and Verbal Memory in Midlife Open
Objective: Tryptophan is an essential amino acid and precursor to several compounds of neurobiological significance, including serotonin, melatonin, and nicotinamide adenine dinucleotide. However, the tryptophan-kynurenine metabolic pathwa…
View article: Gender differences in PTSD severity and pain outcomes: baseline results from the LAMP trial
Gender differences in PTSD severity and pain outcomes: baseline results from the LAMP trial Open
Background Post-traumatic stress disorder (PTSD) and chronic pain are highly prevalent comorbid conditions. Veterans dually burdened by PTSD and chronic pain experience more severe outcomes compared to either disorder alone. Few studies ha…
View article: Lower Body Mass Index at Baseline Is Related to Steeper Cognitive Decline in the Alzheimer’s Disease Neuroimaging Initiative Cohort
Lower Body Mass Index at Baseline Is Related to Steeper Cognitive Decline in the Alzheimer’s Disease Neuroimaging Initiative Cohort Open
Objective Midlife obesity is a risk factor for dementia, whereas obesity in older age may be protective of cognition, a phenomenon known as the “obesity paradox.” The mechanisms underlying this phenomenon and the relationship between body …
View article: Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults
Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults Open
We examined ethnoracial differences in fatty acid binding protein (FABP)—a family of intracellular lipid carriers—and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-His…
View article: Influence of endogenous estrogen on a network model of female brain integrity
Influence of endogenous estrogen on a network model of female brain integrity Open
Recent reports document sex differences in midlife brain integrity and metabolic health, such that more relationships are detectable between metabolic syndrome (MetS) components and markers of brain health in females than in males. Midlife…
View article: Conventional oxygen therapy versus CPAP as a ceiling of care in ward-based patients with COVID-19: a multi-centre cohort evaluation.
Conventional oxygen therapy versus CPAP as a ceiling of care in ward-based patients with COVID-19: a multi-centre cohort evaluation. Open
L Pearmain is supported by the MRC (MR/R00191X/1). TW Felton is supported by the NIHR Manchester Biomedical Research Centre.
View article: Network Modeling Sex Differences in Brain Integrity and Metabolic Health
Network Modeling Sex Differences in Brain Integrity and Metabolic Health Open
Hypothesis-driven studies have demonstrated that sex moderates many of the relationships between brain health and cardiometabolic disease, which impacts risk for later-life cognitive decline. In the present study, we sought to further our …
View article: Metabolic Syndrome and Cognitive Function in Midlife
Metabolic Syndrome and Cognitive Function in Midlife Open
Objective Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with cognitive decline. We investigated the relationship between MetS and cognition in middle-aged adults. We hypothesized that higher numbers of Me…
View article: Exploring Relationships Among Peripheral Amyloid Beta, Tau, Cytokines, Cognitive Function, and Psychosomatic Symptoms in Breast Cancer Survivors
Exploring Relationships Among Peripheral Amyloid Beta, Tau, Cytokines, Cognitive Function, and Psychosomatic Symptoms in Breast Cancer Survivors Open
Objective: Accelerated brain aging has been proposed to explain cancer-related cognitive impairment, but empirical evidence for this relationship is lacking. The purpose of this study was to evaluate amyloid beta (Aβ) and tau, biomarkers o…
View article: Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance
Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance Open
Objective: To investigate the effect of Apolipoprotein E (APOE) genotype on the association between dietary polyunsaturated fat (PUFA), cognitive function, and cerebral glutamate. Methods: A participant sample of 122 middle-a…
View article: Impacts of Metabolic Syndrome Scores on Cerebrovascular Conductance Are Mediated by Arterial Stiffening
Impacts of Metabolic Syndrome Scores on Cerebrovascular Conductance Are Mediated by Arterial Stiffening Open
BACKGROUND Individuals with metabolic syndrome (MetS) exhibit reduced cerebral blood flow. The mechanisms of this reduction remain unknown but arterial stiffening has been implicated as a contributor. We determined if MetS was associated w…
View article: Steady State vs. Pulsatile Blood Pressure Component and Regional Cerebral Perfusion
Steady State vs. Pulsatile Blood Pressure Component and Regional Cerebral Perfusion Open
Arterial blood pressure (BP) can be divided into steady state component that is determined by mean arterial pressure and pulsatile component that is explored by pulse pressure (PP). We determined relationships between BP components and reg…
View article: Beneficial neurocognitive effects of transcranial laser in older adults
Beneficial neurocognitive effects of transcranial laser in older adults Open
View article: Abdominal obesity and white matter microstructure in midlife
Abdominal obesity and white matter microstructure in midlife Open
The aging U.S. population and the recent rise in the prevalence of obesity are two phenomena of great importance to public health. In addition, research suggests that midlife body mass index (BMI) is a risk factor for dementia, a particula…
View article: Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults
Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults Open