Explanipedia

Genetic risk for adult obstructive lung function and its early life associations Open

Casper‐Emil Tingskov Pedersen, Anders Eliasen, Kasper Fischer‐Rasmussen, Vernon Lee, Frederikke Skov , et al. · 2025

Genetic predisposition to obstructive lung function was evident shortly after birth in terms of impaired neonatal lung function and increased susceptibility to severe wheeze, asthma, and lower respiratory tract infections. This indicates p…

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children Open

Emma E. Thompson, Xiaoyuan Zhong, Peter Carbonetto, Andréanne Morin, Jason Willwerscheid , et al. · 2025

Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations Open

Brooke Szczesny, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Randi K. Johnson , et al. · 2025

Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children Open

Emma E. Thompson, Xiaoyuan Zhong, Peter Carbonetto, Andréanne Morin, Jason Willwerscheid , et al. · 2024

Background Asthma is the most common chronic respiratory disease in children, but little is known about genetic contributions to its underlying endotypes. To address this gap, we studied the methylome, transcriptome, and genome from childr…

Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations Open

Brooke Szczesny, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Randi K. Johnson , et al. · 2024

Atopic and non-atopic effects of fish oil supplementation during pregnancy Open

Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann‐Marie Malby Schoos , et al. · 2023

Background We recently conducted a double-blinded randomised controlled trial showing that fish-oil supplementation during pregnancy reduced the risk of persistent wheeze or asthma in the child by 30%. Here, we explore the mechanisms of th…

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort Open

Astrid Sevelsted, Casper‐Emil Tingskov Pedersen, Gözde Gürdeniz, Morten Arendt Rasmussen, Jörg Schullehner , et al. · 2023

Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns Open

Christine Ladd‐Acosta, Elizabeth Vang, Emily S. Barrett, Catherine M. Bulka, Nicole R. Bush , et al. · 2023

Importance Preeclampsia, gestational hypertension, and gestational diabetes, the most common pregnancy complications, are associated with substantial morbidity and mortality in mothers and children. Little is known about the biological pro…

A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome Open

Andréanne Morin, Emma E. Thompson, Britney A. Helling, Lyndsey E. Shorey‐Kendrick, Pieter Faber , et al. · 2023

Nasal DNA methylation at three CpG sites predicts childhood allergic disease Open

Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper‐Emil Tingskov Pedersen, Ilya Petoukhov , et al. · 2022

Prenatal exposure to ambient air pollution is associated with early life immune perturbations Open

Casper‐Emil Tingskov Pedersen, Anders Eliasen, Matthias Ketzel, Jørgen Brandt, Steffen Loft , et al. · 2022

Prenatal exposure to ambient air pollution was associated with early life immune perturbations conferring risk of allergic rhinitis and asthma. These findings suggest potential mechanisms of prenatal exposure to ambient air pollution on th…

Surveying the experience of postdocs in the United States before and during the COVID-19 pandemic Open

Andréanne Morin, Britney A. Helling, Seetha Krishnan, Laurie E. Risner, Nykia D. Walker , et al. · 2022

In the interest of advocating for the postdoctoral community in the United States (US), we compared the results of surveys of postdocs carried out in 2019 and in late 2020. We found that respondents’ mental health and wellness were signifi…

Nasal DNA methylation at three CpG sites predicts childhood allergic disease Open

Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper‐Emil Tingskov Pedersen, Ilya Petoukhov , et al. · 2022

Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of allergen-specific IgE. We hypothe…

A Functional Genomics Pipeline to Identify High-Value Asthma and Allergy CpGs in the Human Methylome Open

Andréanne Morin, Emma E. Thompson, Britney A. Helling, Lyndsey E. Shorey‐Kendrick, Pieter Faber , et al. · 2022

Background DNA methylation of cytosines at CpG dinucleotides is a widespread epigenetic mark; but genome-wide variation has been relatively unexplored due to the limited representation of variable CpGs on commercial high-throughput arrays.…

Author response: Surveying the experience of postdocs in the United States before and during the COVID-19 pandemic Open

Andréanne Morin, Britney A. Helling, Seetha Krishnan, Laurie E. Risner, Nykia D. Walker , et al. · 2022

Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB Open

Anders Eliasen, Casper Pedersen, Morten Arendt Rasmussen, Ni Wang, Matteo Soverini , et al. · 2022

17q12‐q21 variants interact with early‐life exposures to modify asthma risk in Black children Open

Jessica Gereige, Andréanne Morin, Agustin Calatroni, Cynthia M. Visness, R.J.K. Wood , et al. · 2021

MCA reports consulting fees from Regeneron outside the submitted work. JEG has received grants from the NIH; is a paid consultant for AstraZeneca, Meissa Vaccines Inc., and Gossamer Bio; and has stock options in Meissa Vaccines Inc. The da…

The Effect of COVID-19 on the Postdoctoral Experience: a comparison of pre-pandemic and pandemic surveys Open

Andréanne Morin, Britney A. Helling, Seetha Krishnan, Laurie E. Risner, Nykia D. Walker , et al. · 2021

In the interest of advocating for the postdoctoral community in the United States, we present results from survey data collected before and during the COVID-19 pandemic on the same population of postdocs. In 2019, 5,929 postdocs in the US …

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype Open

Daniela Rago, Casper‐Emil Tingskov Pedersen, Mengna Huang, Rachel S. Kelly, Gözde Gürdeniz , et al. · 2021

Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has been suggested, but the underlying mechanisms and characteristics of such an asthma endotype remain to be elucidated.Objectives: To study…

Two‐stage genome‐wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk Open

Marcus M. Soliai, Agnes S. Sundaresan, Andréanne Morin, Annemarie G. Hirsch, Catherine T. Stanhope , et al. · 2021

Chronic rhinosinusitis (CRS) is a prevalent inflammatory disease that results in over $10 billion in health-care costs annually in the United States. CRS (and its most severe form, nasal polyposis [NP]) overlaps clinically with asthma and …

FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses Open

Tarunveer S. Ahluwalia, Anders Eliasen, Astrid Sevelsted, Casper‐Emil Tingskov Pedersen, Jakob Stokholm , et al. · 2020

Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide association study. The discovery analy…

Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age Open

Andréanne Morin, Chris McKennan, Casper-Emil Tingskov Pedersen, Jakob Stokholm, Bo Chawes , et al. · 2020

Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells Open

Anne‐Marie Madore, Lucile Pain, Anne‐Marie Boucher‐Lafleur, Andréanne Morin, Jolyane Meloche , et al. · 2020

<i>GSDMA</i>drives the most replicated association with asthma in naïve CD4<sup>+</sup>T cells Open

Anne‐Marie Madore, Lucile Pain, Anne‐Marie Boucher‐Lafleur, Jolyane Meloche, Andréanne Morin , et al. · 2019

Background The 17q12-21 locus is the most replicated association with asthma. However, no study had described the genetic mechanisms underlying this association considering all genes of the locus in immune cell samples isolated from asthma…

Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome Open

Warren Cheung, Xiaojian Shao, Andréanne Morin, Valérie Siroux, Tony Kwan , et al. · 2019

Following publication of the original article [1], the authors reported an error in Additional file 1.

Additional file 1 of Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome Open

Warren Cheung, Xiaojian Shao, Andréanne Morin, Valérie Siroux, Tony Kwan , et al. · 2019

Description of MCC-Seq capture panel. This file contains: (1) summary of CpGs and genomic regions targeted by the MCC-Seq capture panel design (.xlsx Excel spreadsheet format), and (2) a list of the targeted regions (.bed text file). (ZIP …

Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits Open

Andréanne Morin, Anne‐Marie Madore, Tony Kwan, Maria Ban, Jukka Partanen , et al. · 2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis Open

Cheng‐Jian Xu, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, Olena Gruzieva , et al. · 2018

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle Open

Michelle M. Stein, Emma E. Thompson, Nathan Schoettler, Britney A. Helling, Kevin M. Magnaye , et al. · 2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis Open

Cheng‐Jian Xu, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, Olena Gruzieva , et al. · 2018

Summary Background DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma…

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