Andreas Blaha
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View article: Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse
Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse Open
Fertilization - the process during which sperm and egg find each other, bind and eventually fuse - marks the beginning of a new individual. Research over the past years in vertebrates has shed new light on conserved and divergent molecular…
View article: Bouncer’s receptor on sperm: Investigating sperm-egg compatibility in fish
Bouncer’s receptor on sperm: Investigating sperm-egg compatibility in fish Open
Fertilization requires the successful binding and fusion of sperm and egg. In zebrafish, sperm-egg binding is mediated by the Spaca6-Izumo1-Tmem81 complex on sperm interacting with Bouncer on the egg. We previously found that expressing me…
View article: A conserved fertilization complex bridges sperm and egg in vertebrates
A conserved fertilization complex bridges sperm and egg in vertebrates Open
Fertilization, the basis for sexual reproduction, culminates in the binding and fusion of sperm and egg. Although several proteins are known to be crucial for this process in vertebrates, the molecular mechanisms remain poorly understood. …
View article: A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates
A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates Open
Fertilization, the fusion of sperm and egg, is essential for sexual reproduction. While several proteins have been demonstrated to be essential for the binding and fusion of gametes in vertebrates, the molecular mechanisms driving this key…
View article: Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish
Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish Open
The process of sperm-egg fusion is critical for successful fertilization, yet the underlying mechanisms that regulate these steps have remained unclear in vertebrates. Here, we show that both mouse and zebrafish DCST1 and DCST2 are necessa…
View article: Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation
Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation Open
It is conventionally assumed that conserved pathways evolve slowly with little participation of gene evolution. Nevertheless, it has been recently observed that young genes can take over fundamental functions in essential biological proces…
View article: The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization Open
Significance We show that Bouncer’s homolog in mammals, SPACA4, is required for efficient fertilization in mice. In contrast to fish, in which Bouncer is required for female fertility, SPACA4 is expressed exclusively in the sperm and is re…
View article: Multiple Sources of Introduction of North American <i>Arabidopsis thaliana</i> from across Eurasia
Multiple Sources of Introduction of North American <i>Arabidopsis thaliana</i> from across Eurasia Open
Large-scale movement of organisms across their habitable range, or migration, is an important evolutionary process that can shape genetic diversity and influence the adaptive spread of alleles. Although human migrations have been studied i…
View article: Rapid gene evolution in an ancient post-transcriptional and translational regulatory system compensates for meiotic X chromosomal inactivation
Rapid gene evolution in an ancient post-transcriptional and translational regulatory system compensates for meiotic X chromosomal inactivation Open
SUMMARY It is conventionally assumed that conserved pathways evolve slowly with little participation of gene evolution. Nevertheless, it has been recently observed that young genes can take over fundamental functions in essential biologica…
View article: The sperm protein SPACA4 is required for efficient fertilization in mice
The sperm protein SPACA4 is required for efficient fertilization in mice Open
SUMMARY Fertilization is the fundamental process that initiates the development of a new individual in all sexually reproducing species. Despite its importance, our understanding of the molecular players that govern mammalian sperm-egg int…
View article: Sperm membrane proteins DCST1 and DCST2 are required for the sperm-egg fusion process in mice and fish
Sperm membrane proteins DCST1 and DCST2 are required for the sperm-egg fusion process in mice and fish Open
The process of sperm-egg fusion is critical for successful fertilization, yet the underlying mechanisms that regulate these steps have remained unclear in vertebrates. Here, we show that both mouse and zebrafish DCST1 and DCST2 are necessa…
View article: Fine-scale Population Structure of North American<i>Arabidopsis thaliana</i>Reveals Multiple Sources of Introduction from Across Eurasia
Fine-scale Population Structure of North American<i>Arabidopsis thaliana</i>Reveals Multiple Sources of Introduction from Across Eurasia Open
Large-scale movement of organisms across their habitable range, or migration, is an important evolutionary process that can contribute to observed patterns of genetic diversity and our understanding of the adaptive spread of alleles. While…
View article: <scp>InteBac</scp> : An integrated bacterial and baculovirus expression vector suite
<span>InteBac</span> : An integrated bacterial and baculovirus expression vector suite Open
The successful production of recombinant protein for biochemical, biophysical, and structural biological studies critically depends on the correct expression organism. Currently, the most commonly used expression organisms for structural s…
View article: InteBac - An integrated bacterial and baculovirus expression vector suite
InteBac - An integrated bacterial and baculovirus expression vector suite Open
The successful production of recombinant protein for biochemical, biophysical and structural biological studies critically depends on the correct expression organism. Currently the most commonly used expression organisms for structural stu…