Andreas Büttner
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View article: 23Na MRI quantification of sodium content in porcine eyes after immersion in saltwater and freshwater en route to time in water estimation
23Na MRI quantification of sodium content in porcine eyes after immersion in saltwater and freshwater en route to time in water estimation Open
Background Differentiation between saltwater and freshwater immersion as well as estimating the corpse’s time in water can be challenging. We aimed to establish and examine the feasibility of a novel approach based on sodium magnetic reson…
View article: 2,4-dinitrophenol intoxication and its morphological findings as an indication of substance intake
2,4-dinitrophenol intoxication and its morphological findings as an indication of substance intake Open
Lethal intoxications can only very rarely be recognized during an external examination of corpses, as poisoning does not leave any characteristic findings on the deceased. The present study is a retrospective review on 2,4-dinitrophenol (2…
View article: Magnetic iron-oxide nanoparticles in the brain connected to alcohol-associated liver disease
Magnetic iron-oxide nanoparticles in the brain connected to alcohol-associated liver disease Open
Magnetic iron-oxide nanoparticles in the form of magnetite (Fe3O4) are present in the human brain. They have been hypothesized to biomineralize in situ, as a result of dysfunctional iron homeostasis related to Alzheimer’s disease, or to en…
View article: Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries
Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries Open
Traumatic brain injury (TBI) is a ubiquitous, common sequela of accidents with an annual prevalence of several million cases worldwide. In forensic pathology, structural proteins of the cellular compartments of the CNS in serum and cerebro…
View article: B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 Open
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen 1 . The immunopathology in neuromyelitis optica is largely driven by autoantibodies to A…
View article: Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis
Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis Open
Retinal degeneration protein 3 (RD3) plays a crucial role in controlling guanylate cyclase activity in photoreceptor rod and cone cells, and mediates trafficking processes within photoreceptor cells. Loss of RD3 function correlates with se…
View article: Fatal intoxication with 1,4‐butanediol: Case report and comprehensive review of the literature
Fatal intoxication with 1,4‐butanediol: Case report and comprehensive review of the literature Open
A fatal case of 1,4‐butanediol (1,4‐BD) oral ingestion is reported here, in which a 51‐year‐old man was found dead in his bed. According to the police report, the deceased was a known drug user. A glass bottle labeled (and later confirmed …
View article: Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia Open
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we id…
View article: Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS
Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS Open
The endoprosthetic care of hip and knee joints introduces multiple materials into the human body. Metal containing implant surfaces release degradation products such as particulate wear and corrosion debris, metal-protein complexes, free m…
View article: Abstracts DGAV
Abstracts DGAV Open
Background:Surgery of the parathyroid glands remains a domain of the endocrine surgeon, esp. the clinical aspect, preoperative imaging and biochemical findings are closely related to the surgical strategy.Among larger cohort studies regard…
View article: Primary stability of the Activ L® intervertebral disc prosthesis in cadaver bone and comparison of the keel and spike anchoring concept
Primary stability of the Activ L® intervertebral disc prosthesis in cadaver bone and comparison of the keel and spike anchoring concept Open
Background: High primary stability is the key prerequisite for safe osseointegration of cementless intervertebral disc prosthesis. The aim of our study was to determine the primary stability of intervertebral disc prosthesis with two diffe…
View article: The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine
The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine Open
A 49-year old man was found dead at home next to a glass containing a dried, white, crystalline substance and near a bag containing pills with the imprint XANAX, the trade name of alprazolam. A comprehensive screening of material collected…
View article: Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad
Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad Open
Autoimmune pathology of acute disseminated encephalomyelitis (ADEM) is generally restricted to the brain. Our objective is to expand the phenotype of ADEM. A four-year-old girl was admitted to the pediatric emergency room of a university m…
View article: Testing of primary stability of the Activ® L intervertebral disc prosthesis in cadaver bone and comparison of the two different anchoring concepts – keel and spike anchoring
Testing of primary stability of the Activ® L intervertebral disc prosthesis in cadaver bone and comparison of the two different anchoring concepts – keel and spike anchoring Open
Background: High primary stability is the fundamental prerequisite for safe osseointegration of cementless intervertebral disc prosthesis. The aim of our study was to determine the primary stability of intervertebral disc prosthesis with t…
View article: Delineation of Subregions in the Early Postnatal Human Cerebellum for Design-Based Stereologic Studies
Delineation of Subregions in the Early Postnatal Human Cerebellum for Design-Based Stereologic Studies Open
Recent design-based stereologic studies have shown that the early postnatal (<1 year of age) human cerebellum is characterized by very high plasticity and may thus be very sensitive to external and internal influences during the first year…
View article: Effect of electromagnetic fields on human osteoarthritic and non-osteoarthritic chondrocytes
Effect of electromagnetic fields on human osteoarthritic and non-osteoarthritic chondrocytes Open
A 5 mT EMF increased the expression of cartilage specific genes in OA chondrocytes whereas in non-OA chondrocytes no changes in gene expression were observed. An 8 mT EMF however showed no effect altogether. This suggests that EMF effects …
View article: <i>In Vitro</i> Analysis of the Differentiation Capacity of Postmortally Isolated Human Chondrocytes Influenced by Different Growth Factors and Oxygen Levels
<i>In Vitro</i> Analysis of the Differentiation Capacity of Postmortally Isolated Human Chondrocytes Influenced by Different Growth Factors and Oxygen Levels Open
Objective In the present in vitro study, we analyzed the chondrogenic differentiation capacity of human chondrocytes postmortally isolated from unaffected knee cartilage by the addition of transforming growth factor–β1 (TGF-β1) and/or insu…
View article: Gene expression analysis of growth factor receptors in human chondrocytes in monolayer and 3D pellet cultures
Gene expression analysis of growth factor receptors in human chondrocytes in monolayer and 3D pellet cultures Open
The main goal of cartilage repair is to create functional tissue by enhancing the in vitro conditions to more physiological in vivo conditions. Chondrogenic growth factors play an important role in influencing cartilage homeostasis. Insuli…
View article: Brain Injury due to Mechanical Trauma and Ischemic‐Hypoxic Insult: Biomarkers of Brain Injury and Oxidative Stress
Brain Injury due to Mechanical Trauma and Ischemic‐Hypoxic Insult: Biomarkers of Brain Injury and Oxidative Stress Open
Brain injury (BI) due to mechanical trauma represents one of the major causes of mortality and disability in the world. The pathophysiology of BI is composed of two different pathogenetic moments: primary damage due directly to trauma, wit…
View article: Sehnenabrisse am Becken
Sehnenabrisse am Becken Open
Beckennahe Abrisse von Sehnen sind schwere Verletzungen, die unversorgt Funktionseinbußen zur Folge haben können. Aufgrund des ausgeprägten Weichteilmantels kann die Rupturlokalisation schwer eingeschätzt werden. Klinisch zeigt sich häufig…