Andreas Draguhn
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View article: Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks
Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks Open
Hippocampal pyramidal cells are involved in spatial coding and memory formation. Recent evidence shows that they can be classified according to the origin of their axon, either emerging from the soma (non-AcD for “nonaxon-carrying dendrite…
View article: Similarities and differences between natural sleep and urethane anesthesia
Similarities and differences between natural sleep and urethane anesthesia Open
Slow oscillations dominate the EEG or local field potential (LFP) of mammals during specific periods within natural sleep and anesthesia. Such similarities have led to the use of anesthesia as a model to study sleep and state-dependent cha…
View article: Functional and structural organization of medial entorhinal cortex layer VI
Functional and structural organization of medial entorhinal cortex layer VI Open
Deep layers (V/VI) of the entorhinal cortex transfer hippocampal neuronal activity to downstream neocortical networks. In addition, neurons in layer VI (LVI) of the medial entorhinal cortex (MEC) project back to all hippocampal subregions …
View article: Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions
Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions Open
View article: A tactile discrimination task to study neuronal dynamics in freely-moving mice
A tactile discrimination task to study neuronal dynamics in freely-moving mice Open
Sensory discrimination tasks are valuable tools to study neuronal mechanisms of perception and learning. Most discrimination tasks for electrophysiological and imaging studies in rodents require the animals to be head-fixed. However, imple…
View article: A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model
A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model Open
Neurons in central nervous systems receive multiple synaptic inputs and transform them into a largely standardized output to their target cells—the action potential. A simplified model posits that synaptic signals are integrated by linear …
View article: Correction to: Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Correction to: Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers Open
View article: Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers Open
View article: Are you sometimes lost? Read our new Concept Articles!
Are you sometimes lost? Read our new Concept Articles! Open
View article: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: Author Response: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Author Response: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
Full text Figures and data Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Abstrac…
View article: Author Response: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Author Response: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells
Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells Open
Neurons typically generate action potentials at their axon initial segment based on the integration of synaptic inputs. In many neurons, the axon extends from the soma, equally weighting dendritic inputs. A notable exception is found in a …
View article: GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome
GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome Open
View article: FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL-MEDIAL ENTORHINAL LAYER VI CIRCUIT ALONG THE DORSOVENTRAL AXIS IN MICE
FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL-MEDIAL ENTORHINAL LAYER VI CIRCUIT ALONG THE DORSOVENTRAL AXIS IN MICE Open
View article: Mother trees, altruistic fungi, and the perils of plant personification
Mother trees, altruistic fungi, and the perils of plant personification Open
There are growing doubts about the true role of the common mycorrhizal networks (CMN or wood wide web) connecting the roots of trees in forests. We question the claims of a substantial carbon transfer from 'mother trees' to their offspring…
View article: Glutamate transporter contribution to retinal ganglion cell vulnerability in a rat model of multiple sclerosis
Glutamate transporter contribution to retinal ganglion cell vulnerability in a rat model of multiple sclerosis Open
Glial glutamate transporters actively participate in neurotransmission and have a fundamental role in determining the ambient glutamate concentration in the extracellular space. Their expression is dynamically regulated in many diseases, i…
View article: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: A challenge to claims for mycorrhizal-transmitted wound signaling
A challenge to claims for mycorrhizal-transmitted wound signaling Open
View article: Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway Open
The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and f…
View article: Plant sentience: The burden of proof
Plant sentience: The burden of proof Open
Segundo-Ortin & Calvo’s (2023) target article takes a less speculative and more evidence-based approach to plant sentience than did previous works promoting that idea. However, it retains many of the idea’s longstanding difficulties such a…
View article: Plants lack the functional neurotransmitters and signaling pathways required for sentience in animals
Plants lack the functional neurotransmitters and signaling pathways required for sentience in animals Open
We cannot agree with Segundo-Ortin and Calvo that plants are sentient organisms. We have critically examined several aspects of their target article, and find their claims are not supported by the published evidence. We address these claim…
View article: Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents
Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents Open
The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro el…
View article: Body and mind: how somatic feedback signals shape brain activity and cognition
Body and mind: how somatic feedback signals shape brain activity and cognition Open
View article: Function follows form: how the structure of neurons determines cortical network activity
Function follows form: how the structure of neurons determines cortical network activity Open
View article: Respiration and rapid eye movement (<scp>REM)</scp> sleep substructure: short versus long episodes
Respiration and rapid eye movement (<span>REM)</span> sleep substructure: short versus long episodes Open
Summary Rapid eye movement (REM) sleep in rodents is defined by the presence of theta rhythm in the absence of movement. The amplitude and frequency of theta oscillations have been used to distinguish between tonic and phasic REM sleep. Ho…
View article: Respiratory entrainment of units in the mouse parietal cortex depends on vigilance state
Respiratory entrainment of units in the mouse parietal cortex depends on vigilance state Open
Synchronous oscillations are essential for coordinated activity in neuronal networks and, hence, for behavior and cognition. While most network oscillations are generated within the central nervous system, recent evidence shows that rhythm…
View article: Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents
Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents Open
Summary The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in …