Sebastian Götze
YOU?
Author Swipe
View article: Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies
Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies Open
Sphingoid bases are important bioactive lipids found in a variety of organisms, serving as the backbone of sphingolipids, which regulate essential physiological processes. Here we describe the total synthesis and structure revision of hali…
View article: Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis Open
The cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur‐containing amino lipids (SALs) involved in biofilm formation and marine surface colonization processes. Despite their ph…
View article: Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block
Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block Open
Investigating the ecological context of microbial predator-prey interactions enables the identification of microorganisms, which produce multiple secondary metabolites to evade predation or to kill the predator. In addition, genome mining …
View article: Nonribosomal peptides protect <i>Pseudomonas nunensis</i> 4A2e from amoebal and nematodal predation
Nonribosomal peptides protect <i>Pseudomonas nunensis</i> 4A2e from amoebal and nematodal predation Open
Genome mining of the environmental bacterial isolate Pseudomonas nunensis 4A2e led to the discovery of three novel lipopeptides. Ecology-inspired bioassays highlight their importance in protecting the producing organism against various pre…
View article: Correction: Tyrosine bioconjugation with hypervalent iodine
Correction: Tyrosine bioconjugation with hypervalent iodine Open
Correction for ‘Tyrosine bioconjugation with hypervalent iodine’ by Nina Declas et al. , Chem. Sci. , 2022, 13 , 12808–12817, https://doi.org/10.1039/D2SC04558C.
View article: Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine"
Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine" Open
Raw NMR, IR and MS data and further information on fluorescence experiments and cell uptake studies for the article "Tyrosine Bioconjugation with Hypervalent Iodine" published in Chemical Science, DOI: https://doi.org/10.1039/D2SC04558C Th…
View article: Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine"
Raw data for the article "Tyrosine Bioconjugation with Hypervalent Iodine" Open
Raw NMR, IR and MS data and further information on fluorescence experiments and cell uptake studies for the article "Tyrosine Bioconjugation with Hypervalent Iodine" published in Chemical Science, DOI: https://doi.org/10.1039/D2SC04558C Th…
View article: Tyrosine Bioconjugation with Hypervalent Iodine
Tyrosine Bioconjugation with Hypervalent Iodine Open
Hypervalent iodine reagents have recently emerged as powerful tools for late-stage peptide and protein functionalization. Herein we report a tyrosine bioconjugation methodology for the introduction of hypervalent iodine onto biomolecules u…
View article: Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A
Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A Open
A total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obta…
View article: Tyrosine bioconjugation with hypervalent iodine
Tyrosine bioconjugation with hypervalent iodine Open
A tyrosine bioconjugation for the introduction of hypervalent iodine onto biomolecules is described. The transformation was applied to peptides and proteins and was used to modify native streptavidin to enable thiol-mediated cellular uptak…
View article: Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases
Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases Open
A snapshot of evolution in flagrante shows that recombination within and between biosynthetic genes leads to diversification of nonribosomal peptides.
View article: Synergistic activity of cosecreted natural products from amoebae-associated bacteria
Synergistic activity of cosecreted natural products from amoebae-associated bacteria Open
Significance Bacterially produced small molecules are indispensable leads in the development of antibiotics, anticancer therapeutics, or immunomodulators. To unveil novel aspects in the biosynthetic potential of bacteria, a consideration o…
View article: CCDC 1566928: Experimental Crystal Structure Determination
CCDC 1566928: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine
Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine Open
In recent years, biofilms have become a central subject of research in the fields of microbiology, medicine, agriculture, and systems biology, among others. The sociomicrobiology of multispecies biofilms, however, is still poorly understoo…
View article: <i>Lysinibacillus fusiformis</i>M5 induces increased complexity in<i>Bacillus subtilis</i>168 colony biofilms via hypoxanthine
<i>Lysinibacillus fusiformis</i>M5 induces increased complexity in<i>Bacillus subtilis</i>168 colony biofilms via hypoxanthine Open
In recent years, biofilms have become a central subject of research in the fields of microbiology, medicine, agriculture, or systems biology amongst others. The sociomicrobiology of multispecies biofilms, however, is still poorly understoo…
View article: Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a<i>Toxoplasma gondii</i>mouse challenge model
Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a<i>Toxoplasma gondii</i>mouse challenge model Open
Vaccination against the ubiquitous parasite Toxoplasma gondii would provide the most efficient prevention against toxoplasmosis-related congenital, brain and eye diseases in humans. We investigated the immune response elicited by pathogen-…
View article: Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides
Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides Open
ZG16p is a soluble mammalian lectin that interacts with mannose and heparan sulfate. Here we describe detailed analysis of the interaction of human ZG16p with mycobacterial phosphatidylinositol mannosides (PIMs) by glycan microarray and NM…