Andreas H. Groll
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View article: Correction: Aldejohann et al. Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection. J. Fungi 2025, 11, 618
Correction: Aldejohann et al. Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection. J. Fungi 2025, 11, 618 Open
In the original publication [...]
View article: Hematopoietic stem cell transplantation for purine nucleoside phosphorylase deficiency: an EBMT-IEWP retrospective study
Hematopoietic stem cell transplantation for purine nucleoside phosphorylase deficiency: an EBMT-IEWP retrospective study Open
Purine nucleoside phosphorylase (PNP) deficiency causes inadequate purine metabolite detoxification, leading to combined immunodeficiency and variable neurological symptoms. Hematopoietic stem cell transplantation (HCT) cures the immunodef…
View article: Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection
Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection Open
Mucormycosis is a rare invasive fungal disease in pediatric patients with hematological malignancies and is associated with poor outcomes. We present a fulminant and ultimately fatal case of rhino-orbito-cerebral mucormycosis, addressing i…
View article: Cytomegalovirus prophylaxis with letermovir in pediatric (birth to <18 years of age) hematopoietic cell transplant recipients: pharmacokinetics, efficacy, and safety results of a Phase 2b study
Cytomegalovirus prophylaxis with letermovir in pediatric (birth to <18 years of age) hematopoietic cell transplant recipients: pharmacokinetics, efficacy, and safety results of a Phase 2b study Open
Letermovir, a cytomegalovirus (CMV) terminase complex inhibitor, was first approved for prophylaxis of CMV infection and disease in adult CMV-seropositive allogeneic hematopoietic cell transplant (HCT) recipients (R+). This study evaluated…
View article: Management of Clostridioides difficile infection in patients with haematological malignancies and after cellular therapy: guidelines from 10th European Conference on Infections in Leukaemia (ECIL-10)
Management of Clostridioides difficile infection in patients with haematological malignancies and after cellular therapy: guidelines from 10th European Conference on Infections in Leukaemia (ECIL-10) Open
View article: Utility and Pitfalls of β‐D‐Glucan for Diagnosis and Response Monitoring of Chronic Disseminated Candidiasis in Paediatric Cancer Patients
Utility and Pitfalls of β‐D‐Glucan for Diagnosis and Response Monitoring of Chronic Disseminated Candidiasis in Paediatric Cancer Patients Open
Background β‐D‐Glucan (BDG) is a useful but nonspecific biomarker in patients with suspected invasive fungal diseases including Pneumocystis pneumonia. Little is known, however, about its utility for response monitoring in chronic dissemin…
View article: Liposomal amphotericin B prophylaxis in paediatrics: a systematic review
Liposomal amphotericin B prophylaxis in paediatrics: a systematic review Open
Background Liposomal amphotericin B (LAmB) is widely used for prophylaxis in paediatric patients at high risk of invasive fungal diseases (IFD) but its use is off-label and there is significant variability in dosage and frequency. This sys…
View article: An open abdomen is not a contraindication for ECMO in children with cancer
An open abdomen is not a contraindication for ECMO in children with cancer Open
View article: Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland
Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland Open
Background Invasive fungal diseases (IFD) pose significant challenges in paediatric oncology. Their management is complicated by limited paediatric‐specific evidence, lack of standardised protocols and variability in resources across centr…
View article: Determination of Fluconazole in Children in Small Blood Volumes Using Volumetric Absorptive Microsampling (VAMS) and Isocratic High-Performance Liquid Chromatography–Ultraviolet (HPLC–UV) Detection
Determination of Fluconazole in Children in Small Blood Volumes Using Volumetric Absorptive Microsampling (VAMS) and Isocratic High-Performance Liquid Chromatography–Ultraviolet (HPLC–UV) Detection Open
Objectives: A simple method for quantifying fluconazole in small blood volumes has been developed using volumetric absorptive microsampling (VAMS®) technology and isocratic high-performance liquid chromatography (HPLC) with ultraviolet (UV…
View article: Recombinant myeloid hematopoietic growth factors and clinical stimulation of acute myeloid leukemia cells: a narrative review
Recombinant myeloid hematopoietic growth factors and clinical stimulation of acute myeloid leukemia cells: a narrative review Open
The advent of molecularly cloned hematopoietic growth factors (rhuG-CSF and rhuGM-CSF) enhanced the safety in treating acute myeloid leukemia (AML) by reducing the duration of neutropenia and thus decreasing the risks for infection. Howeve…
View article: Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group
Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group Open
View article: The Paediatric European Confederation of Medical Mycology (<scp>ECMM</scp>) Quality (Paed‐<scp>EQUAL</scp>) <i>Candida</i> Score for the Management of Candidaemia in Children and Neonates
The Paediatric European Confederation of Medical Mycology (<span>ECMM</span>) Quality (Paed‐<span>EQUAL</span>) <i>Candida</i> Score for the Management of Candidaemia in Children and Neonates Open
Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug‐resistant species such as C…
View article: Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM Open
View article: Use of food restrictions to prevent infections in paediatric patients with cancer and haematopoietic cell transplantation recipients: a systematic review and clinical practice guideline
Use of food restrictions to prevent infections in paediatric patients with cancer and haematopoietic cell transplantation recipients: a systematic review and clinical practice guideline Open
View article: P-1196. Drug-Drug Interactions (DDIs) With Letermovir (LET) for Cytomegalovirus (CMV) Prophylaxis in Pediatric (Birth to &lt; 18 years of age) Hematopoietic Cell Transplant (HCT) Recipients
P-1196. Drug-Drug Interactions (DDIs) With Letermovir (LET) for Cytomegalovirus (CMV) Prophylaxis in Pediatric (Birth to < 18 years of age) Hematopoietic Cell Transplant (HCT) Recipients Open
Background HCT recipients receive multiple medications post-transplant, increasing the potential for DDIs. LET, a CMV terminase complex inhibitor approved for CMV prophylaxis in adult CMV-seropositive allogeneic HCT recipients, has the pot…
View article: Acute Exercise Rewires the Proteomic Landscape of Human Immune Cells
Acute Exercise Rewires the Proteomic Landscape of Human Immune Cells Open
View article: Assessing the Theoretical Efficacy of Combination Therapy Against Gram-Negative Infections in Neutropenic Pediatric Cancer Patients: Insights from the Statistical Analysis of Survey Data
Assessing the Theoretical Efficacy of Combination Therapy Against Gram-Negative Infections in Neutropenic Pediatric Cancer Patients: Insights from the Statistical Analysis of Survey Data Open
Background: Empirical antibacterial therapy for febrile neutropenia reduces mortality due to Gram-negative blood stream infections (BSIs). Pediatric guidelines recommend monotherapy with an antipseudomonal beta-lactam or a carbapenem and t…
View article: Safety, outcomes, and pharmacokinetics of isavuconazole as a treatment for invasive fungal diseases in pediatric patients: a non-comparative phase 2 trial
Safety, outcomes, and pharmacokinetics of isavuconazole as a treatment for invasive fungal diseases in pediatric patients: a non-comparative phase 2 trial Open
Invasive aspergillosis (IA) and mucormycosis (IM) cause significant morbidity and mortality in immunocompromised and/or hospitalized patients. Isavuconazonium sulfate, a prodrug of the antifungal triazole isavuconazole, has been approved f…
View article: Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology
Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology Open
Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal path…
View article: Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM Open
View article: Insights into invasive fungal infection diagnostic and treatment capacities in tertiary care centres of Germany
Insights into invasive fungal infection diagnostic and treatment capacities in tertiary care centres of Germany Open
Introduction In Germany, the growing incidence of invasive fungal infections (IFIs) is a significant health concern, particularly impacting individuals with compromised immune systems due to factors like increasing transplant recipients, a…
View article: Triazole antifungal drug interactions—practical considerations for excellent prescribing
Triazole antifungal drug interactions—practical considerations for excellent prescribing Open
Systemic antifungal therapy is critical for reducing the mortality from many invasive and chronic fungal infections. Triazole antifungals are the most frequently prescribed antifungals but require attention to dosing and drug interactions.…
View article: Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease Open
SUMMARY Fungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or m…
View article: <i>Pneumocystis jirovecii</i> pneumonia in paediatric acute lymphoblastic leukaemia: A report from the <scp>multi‐international</scp> clinical trial <scp>AIEOP‐BFM ALL</scp> 2009
<i>Pneumocystis jirovecii</i> pneumonia in paediatric acute lymphoblastic leukaemia: A report from the <span>multi‐international</span> clinical trial <span>AIEOP‐BFM ALL</span> 2009 Open
Summary Pneumocystis jirovecii can cause life‐threatening pneumonia (PjP), and patients with haematological malignancies are at high risk of this infection. Prophylactic measures have significantly decreased morbidity and mortality, but th…
View article: Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion”
Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion” Open
International audience
View article: Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM Open
View article: Pharmacokinetics, Safety, and Efficacy of Letermovir for Cytomegalovirus Prophylaxis in Adolescent Hematopoietic Cell Transplantation Recipients
Pharmacokinetics, Safety, and Efficacy of Letermovir for Cytomegalovirus Prophylaxis in Adolescent Hematopoietic Cell Transplantation Recipients Open
Introduction: Letermovir is a cytomegalovirus (CMV) terminase complex inhibitor approved for prophylaxis of CMV infection and disease in adult CMV-seropositive allogeneic hematopoietic cell transplantation (allo-HCT) recipients (R+). We re…
View article: Melanoma of the central nervous system based on neurocutaneous melanocytosis in childhood: A rare but fatal condition
Melanoma of the central nervous system based on neurocutaneous melanocytosis in childhood: A rare but fatal condition Open
Background Melanomas of the central nervous system (CNS) based on neurocutaneous melanocytosis (NCM) are exceptionally rare in childhood and have been described only sporadically. Rapidly progressive disease may represent a major challenge…
View article: General Management of the Patient: Specific Aspects of Infectious Disease Supportive Care in Children
General Management of the Patient: Specific Aspects of Infectious Disease Supportive Care in Children Open
Many of the conditions requiring allogeneic HCT and related complications are similar in adults and children and are covered in other chapters of this handbook. However, there are a few exceptions where approaches to management can be diff…