Andreas Güldner
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View article: Effects of the primary lung infection on outcomes in patients with severe ARDS treated with ECMO: a retrospective analysis
Effects of the primary lung infection on outcomes in patients with severe ARDS treated with ECMO: a retrospective analysis Open
Introduction Acute respiratory distress syndrome (ARDS) requiring veno-venous extracorporeal membrane oxygenation (vvECMO) remains associated with high mortality. Whether etiology-based differentiation within infectious ARDS improves progn…
View article: Nucleated red blood cells as a prognostic marker for mortality in septic critically ill patients: An observational study
Nucleated red blood cells as a prognostic marker for mortality in septic critically ill patients: An observational study Open
Measuring NRBCs can help predict mortality in septic critically ill patients with high prognostic accuracy. A cut-off of ≥100/µL for NRBCs appears to effectively stratify the study population regarding mortality.
View article: The effect of antibiotic therapy on clinical outcome in patients hospitalized with moderate COVID-19 disease: a prospective multi-center cohort study
The effect of antibiotic therapy on clinical outcome in patients hospitalized with moderate COVID-19 disease: a prospective multi-center cohort study Open
Purpose The benefit of antibiotic treatment (ABT) for patients with moderate COVID-19 is unclear and overtreatment poses the risk of adverse effects such as Clostridioides difficile infection and antibiotic resistance. This multi-center st…
View article: Long-term characteristics and outcomes of septic critically ill patients with and without COVID-19
Long-term characteristics and outcomes of septic critically ill patients with and without COVID-19 Open
In our cohort of septic critically ill patients, health-related quality of life and long-term survival were considerably reduced in patients with concomitant COVID-19. Furthermore, COVID-19 could be identified as an independent risk factor…
View article: Post-COVID-19-pandemic changes and clinical characteristics of invasive group a streptococcal infections from 2015 to 2023
Post-COVID-19-pandemic changes and clinical characteristics of invasive group a streptococcal infections from 2015 to 2023 Open
Purpose Since winter 2022, invasive GAS (iGAS) infections have re-emerged in Europe, causing severe diseases in children and adults. We aimed to examine whether this reported post-pandemic increase was associated with an increased disease …
View article: PB1221 Prospective Study Comparing Point-of-Care Viscoelastic Testing and Standard Laboratory Testing for the Prediction of Bleeding Complications in Patients after Systemic Thrombolysis Therapy
PB1221 Prospective Study Comparing Point-of-Care Viscoelastic Testing and Standard Laboratory Testing for the Prediction of Bleeding Complications in Patients after Systemic Thrombolysis Therapy Open
Background: Thrombolysis therapy in patients with stroke or pulmonary embolism is associated with bleeding complications which typically occur in up to 9.9% (1,2).Identification of patient with increased risk for bleeding possibly can infl…
View article: Barriers and opportunities for implementation of a brief psychological intervention for post-ICU mental distress in the primary care setting – results from a qualitative sub-study of the PICTURE trial
Barriers and opportunities for implementation of a brief psychological intervention for post-ICU mental distress in the primary care setting – results from a qualitative sub-study of the PICTURE trial Open
Background The results of critical illness and life-saving invasive measures during intensive care unit treatment can sometimes lead to lasting physical and psychological impairments. A multicentre randomized controlled trial from Germany …
View article: Treatment of Acquired von Willebrand Disease due to Extracorporeal Membrane Oxygenation in a Pediatric COVID-19 Patient with Vonicog Alfa: A Case Report and Literature Review
Treatment of Acquired von Willebrand Disease due to Extracorporeal Membrane Oxygenation in a Pediatric COVID-19 Patient with Vonicog Alfa: A Case Report and Literature Review Open
Acquired von Willebrand disease (aVWD) is frequently observed in patients with the need for extracorporeal membrane oxygenation (ECMO). aVWD can be treated by plasma-derived concentrates containing factor VIII (FVIII) and/or von Willebrand…
View article: Enhancing Anticoagulation Monitoring and Therapy in Patients Undergoing Microvascular Reconstruction in Maxillofacial Surgery: A Prospective Observational Trial
Enhancing Anticoagulation Monitoring and Therapy in Patients Undergoing Microvascular Reconstruction in Maxillofacial Surgery: A Prospective Observational Trial Open
Background: In reconstructive surgery, loss of a microvascular free flap due to perfusion disorders, especially thrombosis, is a serious complication. In recent years, viscoelastic testing (VET) has become increasingly important in point-o…
View article: COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis Open
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we system…
View article: Characteristics And Outcomes of Sepsis Patients With And Without COVID-19
Characteristics And Outcomes of Sepsis Patients With And Without COVID-19 Open
Background: The aim of this study was to describe and compare clinical characteristics and outcomes in critically ill septic patients with and without COVID-19. Methods : From February 2020 to March 2021, patients from surgical and medical…
View article: A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease Open
Nitric oxide (NO)-cyclic GMP (cGMP) signaling is a vasoprotective pathway therapeutically targeted for example in pulmonary hypertension. Its dysregulation in disease is incompletely understood. Here we show in pulmonary artery endothelial…
View article: Periodic Fluctuation of Tidal Volumes Further Improves Variable Ventilation in Experimental Acute Respiratory Distress Syndrome
Periodic Fluctuation of Tidal Volumes Further Improves Variable Ventilation in Experimental Acute Respiratory Distress Syndrome Open
In experimental acute respiratory distress syndrome (ARDS), random variation of tidal volumes (VT ) during volume controlled ventilation improves gas exchange and respiratory system mechanics (so-called stochastic resonance hypothesis). It…