Andreas J. Meyer
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View article: The secreted redox sensor roGFP2‐Orp1 reveals oxidative dynamics in the plant apoplast
The secreted redox sensor roGFP2‐Orp1 reveals oxidative dynamics in the plant apoplast Open
Specific generation of reactive oxygen species (ROS) is important for signalling and defence in many organisms. In plants, different types of ROS serve useful biological functions in the extracellular space (apoplast), influencing polymer …
View article: Fusion of a bacterial cysteine desulfurase to redox-sensitive green fluorescent protein produces a highly sensitive cysteine biosensor for monitoring changes in intracellular cysteine
Fusion of a bacterial cysteine desulfurase to redox-sensitive green fluorescent protein produces a highly sensitive cysteine biosensor for monitoring changes in intracellular cysteine Open
Over the last two decades, the development of fluorescent probes has transformed the way of measuring physiological parameters in intact cells, including in the field of redox biology. We developed a genetically encoded biosensor called Cy…
View article: Diversification of glutathione transferases in plants and their role in oxidative stress defense
Diversification of glutathione transferases in plants and their role in oxidative stress defense Open
Plant exposure to unfavourable environmental conditions causes stress and reduces productivity. A common consequence of stress responses, are increased levels of reactive oxygen species (ROS), which if not controlled, could eventually lead…
View article: Advanced illumination-imaging reveals photosynthesis-triggered pH, ATP and NAD redox signatures across plant cell compartments
Advanced illumination-imaging reveals photosynthesis-triggered pH, ATP and NAD redox signatures across plant cell compartments Open
Photosynthesis provides energy and organic substrates to most life. In plants, photosynthesis dominates chloroplast physiology but represents only a fraction of the tightly interconnected metabolic network that spans the entire cell. Here,…
View article: Abscisic acid signaling gates salt-induced responses of plant roots
Abscisic acid signaling gates salt-induced responses of plant roots Open
Soil salinity presents a dual challenge for plants, involving both osmotic and ionic stress. In response, plants deploy distinct yet interconnected mechanisms to cope with these facets of salinity stress. In this investigation, we observed…
View article: The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast
The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast Open
Summary - Specific generation of reactive oxygen species (ROS) is important for signalling and defence in many organisms. In plants, different types of ROS serve useful biological functions in the extracellular space (apoplast), influencin…
View article: Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants
Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants Open
After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are …
View article: Protein persulfidation in plants: mechanisms and functions beyond a simple stress response
Protein persulfidation in plants: mechanisms and functions beyond a simple stress response Open
Posttranslational modifications (PTMs) can modulate the activity, localization and interactions of proteins and (re)define their biological function. Understanding how changing environments can alter cellular processes thus requires detail…
View article: Localization of four class I glutaredoxins in the cytosol and the secretory pathway and characterization of their biochemical diversification
Localization of four class I glutaredoxins in the cytosol and the secretory pathway and characterization of their biochemical diversification Open
SUMMARY Class I glutaredoxins (GRXs) are catalytically active oxidoreductases and considered key proteins mediating reversible glutathionylation and deglutathionylation of protein thiols during development and stress responses. To narrow i…
View article: Contrasting cytosolic glutathione redox dynamics under abiotic and biotic stress in barley as revealed by the biosensor Grx1–roGFP2
Contrasting cytosolic glutathione redox dynamics under abiotic and biotic stress in barley as revealed by the biosensor Grx1–roGFP2 Open
Barley is a staple crop of major global importance and relatively resilient to a wide range of stress factors in the field. Transgenic reporter lines to investigate physiological parameters during stress treatments remain scarce. We genera…
View article: Abscisic acid signaling gates salt-specific responses of plant roots
Abscisic acid signaling gates salt-specific responses of plant roots Open
Soil salinity presents a dual challenge for plants, involving both osmotic and ionic stress. In response, plants deploy distinct yet interconnected mechanisms to cope with these facets of salinity stress. In this investigation, we observed…
View article: Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VITAMIN E PATHWAY GENE5 (VTE5) and the farnesol kinase (FOLK)
Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VITAMIN E PATHWAY GENE5 (VTE5) and the farnesol kinase (FOLK) Open
Chlorophyll degradation causes the release of phytol, which is converted into phytyl diphosphate (phytyl-PP) by phytol kinase (VITAMIN E PATHWAY GENE5 [VTE5]) and phytyl phosphate (phytyl-P) kinase (VTE6). The kinase pathway is important f…
View article: Chloroplasts lacking class I glutaredoxins are functional but show a delayed recovery of protein cysteinyl redox state after oxidative challenge
Chloroplasts lacking class I glutaredoxins are functional but show a delayed recovery of protein cysteinyl redox state after oxidative challenge Open
Redox status of protein cysteinyl residues is mediated via glutathione (GSH)/glutaredoxin (GRX) and thioredoxin (TRX)-dependent redox cascades. An oxidative challenge can induce post-translational protein modifications on thiols, such as p…
View article: PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 2 localizes to the Golgi
PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 2 localizes to the Golgi Open
In contrast to its close homolog PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 1 (UCP1), which is an abundant carrier protein in the mitochondria, UCP2 localizes to the Golgi.
View article: CYP79B2 and CYP79B3 contribute to root branching through production of the auxin precursor indole-3-acetonitrile
CYP79B2 and CYP79B3 contribute to root branching through production of the auxin precursor indole-3-acetonitrile Open
Lateral root placement, outgrowth and density are influenced by environmental changes, including salinity stress. CYP79B2 and B3 are two cytochrome P450 enzymes previously identified as required for root architecture remodeling in salt. Th…
View article: Localization of four class I glutaredoxins in the cytosol and the secretory pathway and characterization of their biochemical diversification
Localization of four class I glutaredoxins in the cytosol and the secretory pathway and characterization of their biochemical diversification Open
Class I glutaredoxins (GRXs) are catalytically active oxidoreductases and considered key proteins mediating reversible glutathionylation and deglutathionylation of protein thiols during development and stress responses. To narrow in on put…
View article: Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide
Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide Open
Iron–sulfur (Fe–S) cluster are vital cofactors in all domains of life. Mitochondrial Fe–S cluster assembly occurs in two major steps to first build [2Fe–2S] clusters and subsequently assemble these into [4Fe–4S] clusters. The two assembly …
View article: PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 2 localizes to the Golgi
PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 2 localizes to the Golgi Open
Mitochondria act as cellular hubs of energy transformation and metabolite conversion in most eukaryotes. Plant mitochondrial electron transport chains are particularly flexible, featuring alternative components, such as ALTERNATIVE NAD(P)H…
View article: Root branching in salt requires auxin-independent modulation of LBD16 function
Root branching in salt requires auxin-independent modulation of LBD16 function Open
Salinity stress constrains lateral root (LR) growth and severely impacts plant growth. Auxin signaling is indispensable for the regulation of LR formation. Nevertheless, the molecular mechanism of how salinity affects root auxin signaling …
View article: Natural variation in salt‐induced root growth phases and their contribution to root architecture plasticity
Natural variation in salt‐induced root growth phases and their contribution to root architecture plasticity Open
The root system architecture of a plant changes during salt stress exposure. Different accessions of Arabidopsis thaliana have adopted different strategies in remodelling their root architecture during salt stress. Salt induces a multiphas…
View article: Assembly, transfer, and fate of mitochondrial iron–sulfur clusters
Assembly, transfer, and fate of mitochondrial iron–sulfur clusters Open
Since the discovery of an autonomous iron–sulfur cluster (Fe–S) assembly machinery in mitochondria, significant efforts to examine the nature of this process have been made. The assembly of Fe–S clusters occurs in two distinct steps with t…
View article: Redox-mediated responses to high temperature in plants
Redox-mediated responses to high temperature in plants Open
As sessile organisms, plants are particularly affected by climate change and will face more frequent and extreme temperature variations in the future. Plants have developed a diverse range of mechanisms allowing them to perceive and respon…
View article: Natural variation in salt-induced root growth phases and their contribution to root architecture plasticity
Natural variation in salt-induced root growth phases and their contribution to root architecture plasticity Open
During salt stress, the root system architecture of a plant is important for survival. Different accessions of Arabidopsis thaliana have adopted different strategies in remodeling their root architecture during salt stress. Salt induces a …
View article: Signal Peptide Efficiency: From High-Throughput Data to Prediction and Explanation
Signal Peptide Efficiency: From High-Throughput Data to Prediction and Explanation Open
The passage of proteins across biological membranes via the general secretory (Sec) pathway is a universally conserved process with critical functions in cell physiology and important industrial applications. Proteins are directed into the…
View article: High robustness of cytosolic glutathione redox potential under combined salt and osmotic stress in barley as revealed by the biosensor Grx1-roGFP2
High robustness of cytosolic glutathione redox potential under combined salt and osmotic stress in barley as revealed by the biosensor Grx1-roGFP2 Open
Barley is a staple crop of major global importance and relatively resilient to a wide range of stress factors in the field. Transgenic reporter lines to investigate physiological parameters during stress treatments remain scarce. We genera…
View article: Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics
Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics Open
Oxidative protein folding in the endoplasmic reticulum (ER) depends on the coordinated action of protein disulfide isomerases and ER oxidoreductins (EROs). Strict dependence of ERO activity on molecular oxygen as the final electron accepto…
View article: Discriminative Long-Distance Transport of Selenate and Selenite Triggers Glutathione Oxidation in Specific Subcellular Compartments of Root and Shoot Cells in Arabidopsis
Discriminative Long-Distance Transport of Selenate and Selenite Triggers Glutathione Oxidation in Specific Subcellular Compartments of Root and Shoot Cells in Arabidopsis Open
Selenium is an essential trace element required for seleno-protein synthesis in many eukaryotic cells excluding higher plants. However, a substantial fraction of organically bound selenide in human nutrition is directly or indirectly deriv…
View article: Signal Peptide Efficiency: from High-throughput Data to Prediction and Explanation
Signal Peptide Efficiency: from High-throughput Data to Prediction and Explanation Open
The passage of proteins across biological membranes via the general secretory (Sec) pathway is a universally conserved process with critical functions in cell physiology and important industrial applications. Proteins are directed into the…