Andreas Korzowski
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View article: Exploring the 31P chemical shift behavior of high-energy phosphates at 7 T in patients with glioma
Exploring the 31P chemical shift behavior of high-energy phosphates at 7 T in patients with glioma Open
Introduction The characterization of tumor microenvironment in vivo can be supported by 31 P MRSI, a non-invasive technique that enables the determination of intracellular pH and magnesium ion concentration, among other parameters. However…
View article: Radial multi‐echo <scp>bSSFP</scp> and <scp>IDEAL</scp> chemical shift separation in k‐space for high‐speed <scp>3D</scp> hyperpolarized <scp><sup>13</sup>C</scp> metabolic <scp>MRI</scp>
Radial multi‐echo <span>bSSFP</span> and <span>IDEAL</span> chemical shift separation in k‐space for high‐speed <span>3D</span> hyperpolarized <span><sup>13</sup>C</span> metabolic <span>MRI</span> Open
Purpose Hyperpolarized (HP) carbon‐13 ( 13 C) MRSI provides real‐time information about metabolic processes but lacks high temporal and spatial resolution. This study introduces a multi‐echo–balanced steady‐state free precession (ME‐bSSFP)…
View article: Human liver <scp>CEST</scp> imaging at 7 T: Impact of B1+ shimming
Human liver <span>CEST</span> imaging at 7 T: Impact of B1+ shimming Open
Purpose To explore the feasibility of CEST imaging in the human liver at 7 T with shimming. Methods CEST MRI was performed on a 7 T whole‐body scanner with a parallel transmission (pTx) system in five healthy volunteers. Static pTx ( shimm…
View article: Open‐source implementation of X‐nuclear sequences using the Pulseq framework
Open‐source implementation of X‐nuclear sequences using the Pulseq framework Open
Purpose Create vendor‐neutral modular sequences for X‐nuclear acquisitions and build an X‐nuclear–enabled Pulseq interpreter for GE (GE HealthCare, Waukesha, WI) scanners. Methods We designed a modular 2D gradient echo spiral sequence to s…
View article: Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized <scp><sup>13</sup>C MRSI</scp> in vivo
Three‐dimensional radial echo‐planar spectroscopic imaging for hyperpolarized <span><sup>13</sup>C MRSI</span> in vivo Open
Purpose To demonstrate the feasibility of 3D echo‐planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k‐space sampling for hyperpolarized (HP) 13 C magnetic resonance spectroscopic imaging (MRSI) in vivo. Methods A r…
View article: A versatile look‐up algorithm for mapping pH values and magnesium ion content using <sup>31</sup>P MRSI
A versatile look‐up algorithm for mapping pH values and magnesium ion content using <sup>31</sup>P MRSI Open
31 P MRSI allows for the non‐invasive mapping of pH and magnesium ion content (Mg) in vivo, by translating the chemical shifts of inorganic phosphate and adenosine‐5′‐triphosphate (ATP) to pH and Mg via suitable calibration equations, such…
View article: Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution <sup>31</sup>P MR Spectroscopic Imaging at 7.0 T
Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution <sup>31</sup>P MR Spectroscopic Imaging at 7.0 T Open
Malignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pHi). In this prospective study, pHi values in gliomas were q…
View article: First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain
First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain Open
View article: Post-Surgical Depositions of Blood Products Are No Major Confounder for the Diagnostic and Prognostic Performance of CEST MRI in Patients with Glioma
Post-Surgical Depositions of Blood Products Are No Major Confounder for the Diagnostic and Prognostic Performance of CEST MRI in Patients with Glioma Open
Amide proton transfer (APT) and semi-solid magnetization transfer (ssMT) imaging can predict clinical outcomes in patients with glioma. However, the treatment of brain tumors is accompanied by the deposition of blood products within the tu…
View article: Semi‐solid <scp>MT</scp> and <scp>APTw CEST‐MRI</scp> predict clinical outcome of patients with glioma early after radiotherapy
Semi‐solid <span>MT</span> and <span>APTw CEST‐MRI</span> predict clinical outcome of patients with glioma early after radiotherapy Open
Purpose The purpose of this study was to compare the potential of asymmetry‐based (APTw asym ), Lorentzian‐fit‐based (PeakAreaAPT and MT const ), and relaxation‐compensated (MTR Rex APT and MTR Rex MT) CEST contrasts of the amide proton tr…
View article: <scp><sup>31</sup>P MRSI</scp>at 7 T enables high‐resolution volumetric mapping of the intracellular magnesium ion content in human lower leg muscles
<span><sup>31</sup>P MRSI</span>at 7 T enables high‐resolution volumetric mapping of the intracellular magnesium ion content in human lower leg muscles Open
Purpose The non‐invasive determination of the free magnesium ion concentration ([Mg 2+ free ]) using 31 P MRSI in vivo is of interest in research on various pathologies, e.g. diabetes. The purpose of this study was to demonstrate the poten…
View article: Motion correction for three‐dimensional chemical exchange saturation transfer imaging without direct water saturation artifacts
Motion correction for three‐dimensional chemical exchange saturation transfer imaging without direct water saturation artifacts Open
In chemical exchange saturation transfer (CEST) MRI, motion correction is compromised by the drastically changing image contrast at different frequency offsets, particularly at the direct water saturation. In this study, a simple extension…
View article: Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T
Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T Open
Purpose In principle, non‐invasive mapping of the intracellular pH (pH i ) in vivo is possible using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and guanidyl signals. However, the application for cancer imaging…
View article: Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution 31P MRSI at 7T
Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution 31P MRSI at 7T Open
Phosphorus magnetic resonance spectroscopic imaging ( 31 P MRSI) is of particular interest for investigations of patients with brain tumors as it enables to non-invasively assess altered energy and phospholipid metabolism in vivo . However…
View article: Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T
Clinical routine acquisition protocol for 3D relaxation‐compensated APT and rNOE CEST‐MRI of the human brain at 3T Open
Purpose The value of relaxation‐compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)‐MRI has already been demonstrated in various neuro‐oncological clinical appli…
View article: Volumetric mapping of intra‐ and extracellular pH in the human brain using <sup>31</sup>P MRSI at 7T
Volumetric mapping of intra‐ and extracellular pH in the human brain using <sup>31</sup>P MRSI at 7T Open
Purpose In vivo 31 P MRSI enables noninvasive mapping of absolute pH values via the pH‐dependent chemical shifts of inorganic phosphates (P i ). A particular challenge is the quantification of extracellular P i with low SNR in vivo. The pu…
View article: Double‐tuned <sup>31</sup>P/<sup>1</sup>H human head array with high performance at both frequencies for spectroscopic imaging at 9.4T
Double‐tuned <sup>31</sup>P/<sup>1</sup>H human head array with high performance at both frequencies for spectroscopic imaging at 9.4T Open
Purpose To develop a robust design of a human head double‐tuned 31 P/ 1 H array, which provides good performance at both 31 P and 1 H frequencies for MR spectroscopic imaging at 9.4T. Methods Increasing the number of surface loops in a hum…
View article: Dynamic glucose‐enhanced (DGE) MRI in the human brain at 7 T with reduced motion‐induced artifacts based on quantitative R<sub>1ρ</sub> mapping
Dynamic glucose‐enhanced (DGE) MRI in the human brain at 7 T with reduced motion‐induced artifacts based on quantitative R<sub>1ρ</sub> mapping Open
Purpose Dynamic glucose‐enhanced (DGE)‐MRI based on chemical exchange‐sensitive MRI, that is, glucoCEST and gluco‐chemical exchange‐sensitive spin‐lock (glucoCESL), is intrinsically prone to motion‐induced artifacts because the final DGE c…
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View article: A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging
A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging Open
Purpose The application of amide proton transfer (APT) CEST MRI for diagnosis of breast cancer is of emerging interest. However, APT imaging in the human breast is affected by the ubiquitous fat signal preventing a straightforward applicat…
View article: FullHD CEST Bildgebung des Gehirns bei 7T
FullHD CEST Bildgebung des Gehirns bei 7T Open
Einleitung: Spektral hochaufgelöste in vivo Z-Spektren können zu einer besseren Identifizierung von CEST Substrukturen, aber auch für quantitative CEST Evaluierungen oder Machine-Learning Ansätze genutzt werden. Die zusätzlich benötigte Me…
View article: High‐resolution <sup>31</sup><scp>P</scp> echo‐planar spectroscopic imaging in vivo at 7<scp>T</scp>
High‐resolution <sup>31</sup><span>P</span> echo‐planar spectroscopic imaging in vivo at 7<span>T</span> Open
Purpose Conventional 31 P chemical shift imaging is time‐consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of 31 P echo‐planar spectroscopic imaging (EPSI) in vivo at 7T. Methods…
View article: Adiabatically prepared spin‐lock approach for T1ρ‐based dynamic glucose enhanced MRI at ultrahigh fields
Adiabatically prepared spin‐lock approach for T1ρ‐based dynamic glucose enhanced MRI at ultrahigh fields Open
Purpose Chemical exchange sensitive spin‐lock and related techniques allow to observe the uptake of administered D‐glucose in vivo. The exchange‐weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequenc…
View article: Echo-planare 31P-NMR-spektroskopische Bildgebung in vivo bei 7T
Echo-planare 31P-NMR-spektroskopische Bildgebung in vivo bei 7T Open
31P-NMR-Spektroskopie ermöglicht die nicht-invasive Beobachtung des Energiestoffwechsels im lebenden Gewebe. In dieser Arbeit wurde eine echo-planare 31P-spektroskopische Bildgebungsmethode (31P-EPSI) für In-vivo-Messungen bei einer Magnet…