Andreas Kühbacher
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View article: Proline catabolism is a key factor facilitating Candida albicans pathogenicity
Proline catabolism is a key factor facilitating Candida albicans pathogenicity Open
Candida albicans , the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/- strains, carrying def…
View article: Proline catabolism is key to facilitating <i>Candida albicans</i> pathogenicity
Proline catabolism is key to facilitating <i>Candida albicans</i> pathogenicity Open
Candida albicans , the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/ - strains, carrying de…
View article: Listeriolysin O-dependent host surfaceome remodeling modulates<i>Listeria monocytogenes</i>invasion
Listeriolysin O-dependent host surfaceome remodeling modulates<i>Listeria monocytogenes</i>invasion Open
Listeria monocytogenes is a pathogenic bacterium that invades epithelial cells by activating host signaling cascades, which promote bacterial engulfment within a phagosome. The pore-forming toxin listeriolysin O (LLO), which is required fo…
View article: Interaction of Candida Species with the Skin
Interaction of Candida Species with the Skin Open
The human skin is commonly colonized by diverse fungal species. Some Candida species, especially C. albicans, do not only reside on the skin surface as commensals, but also cause infections by growing into the colonized tissue. However, de…
View article: Central Role for Dermal Fibroblasts in Skin Model Protection against Candida albicans
Central Role for Dermal Fibroblasts in Skin Model Protection against Candida albicans Open
The fungal pathogen Candida albicans colonizes basically all human epithelial surfaces, including the skin. Under certain conditions, such as immunosuppression, invasion of the epithelia occurs. Not much is known about defense mechanisms a…
View article: Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in <i>Listeria</i> Infection and Reveals Different Actin Nucleation Mechanisms during <i>Listeria</i> Cell Invasion and Actin Comet Tail Formation
Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in <i>Listeria</i> Infection and Reveals Different Actin Nucleation Mechanisms during <i>Listeria</i> Cell Invasion and Actin Comet Tail Formation Open
Listeria monocytogenes enters nonphagocytic cells by a receptor-mediated mechanism that is dependent on a clathrin-based molecular machinery and actin rearrangements. Bacterial intra- and intercellular movements are also actin dependent an…