Andreas Leiherer
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View article: Interplay of kidney function and anti-SARS-CoV-2 antibodies in COVID-19 mortality: a prospective cohort study
Interplay of kidney function and anti-SARS-CoV-2 antibodies in COVID-19 mortality: a prospective cohort study Open
CKD has been recognized as an independent risk factor for severe disease and death in COVID-19. Given the high variability in humoral responses, their general decrease in strength, quality, and durability with age, and the decline of antib…
View article: Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets
Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets Open
Ceramides are bioactive lipid mediators involved in apoptosis, inflammation, and fibrosis. This narrative review provides a concise overview of the emerging role of ceramides in cardiovascular disease with an emphasis on atherosclerotic va…
View article: Evaluation of Circulating Glypican-4 in Patients with ESKD
Evaluation of Circulating Glypican-4 in Patients with ESKD Open
Key Points Glypican-4 (GPC4) levels were strongly elevated in incident dialysis patients compared with individuals without evidence of kidney disease. Circulating GPC4 was significantly correlated with various parameters linked to adverse …
View article: Special Issue “Machine Learning and Bioinformatics in Human Health and Disease”—Chances and Challenges
Special Issue “Machine Learning and Bioinformatics in Human Health and Disease”—Chances and Challenges Open
Machine learning (ML) and bioinformatics are catalyzing a new era in biomedical research, enabling unprecedented insights into the complex systems that govern human health and disease [...]
View article: Antibody levels versus vaccination status in the outcome of older adults with COVID-19
Antibody levels versus vaccination status in the outcome of older adults with COVID-19 Open
BACKGROUNDDespite the currently prevailing, milder Omicron variant of COVID-19, older adults remain at elevated risk of hospital admission, critical illness, and death. Loss of efficacy of the immune system, including reduced strength, qua…
View article: Anti-SARS-CoV-2 Antibodies versus Vaccination Status in CAD Patients with COVID-19: A Prospective, Propensity Score-Matched Cohort Study
Anti-SARS-CoV-2 Antibodies versus Vaccination Status in CAD Patients with COVID-19: A Prospective, Propensity Score-Matched Cohort Study Open
Objectives: Despite the currently prevailing, milder Omicron variant, coronary artery disease (CAD) patients constitute a major risk group in COVID-19, exhibiting 2.6 times the mortality risk of non-CAD patients and representing over 22% o…
View article: Current Practices of Medication Plans in Austrian Patients Undergoing Coronary Angiography: An In-Depth Analysis
Current Practices of Medication Plans in Austrian Patients Undergoing Coronary Angiography: An In-Depth Analysis Open
A complete medication plan (MPlan) increases medication safety and adherence and is crucial in care transitions. Countries that implemented a standardized MPlan reported benefits on patients’ understanding and handling of their medication.…
View article: Machine Learning Approach to Metabolomic Data Predicts Type 2 Diabetes Mellitus Incidence
Machine Learning Approach to Metabolomic Data Predicts Type 2 Diabetes Mellitus Incidence Open
Metabolomics, with its wealth of data, offers a valuable avenue for enhancing predictions and decision-making in diabetes. This observational study aimed to leverage machine learning (ML) algorithms to predict the 4-year risk of developing…
View article: Interplay of inflammatory markers and anti-SARS-CoV-2 antibodies in COVID-19 mortality: A prospective cohort study
Interplay of inflammatory markers and anti-SARS-CoV-2 antibodies in COVID-19 mortality: A prospective cohort study Open
Hospitalized COVID-19 patients presenting with high inflammatory markers and low antibody levels exhibited the highest mortality risks. Higher antibody levels are associated with lower levels of inflammation in hospitalized COVID-19 patien…
View article: The value of earlier-in-life systolic and diastolic blood pressure for cardiovascular risk prediction
The value of earlier-in-life systolic and diastolic blood pressure for cardiovascular risk prediction Open
View article: Ceramides improve cardiovascular risk prediction beyond low-density lipoprotein cholesterol
Ceramides improve cardiovascular risk prediction beyond low-density lipoprotein cholesterol Open
Aims Low-density lipoprotein cholesterol (LDL-C) is the best documented cardiovascular risk predictor and at the same time serves as a target for lipid-lowering therapy. However, the power of LDL-C to predict risk is biased by advanced age…
View article: Remnant cholesterol predicts major cardiovascular events in cardiovascular disease patients with NAFLD
Remnant cholesterol predicts major cardiovascular events in cardiovascular disease patients with NAFLD Open
Remnant cholesterol has attracted interest as a marker of cardiovascular event risk. The purpose of this study was to assess the power of remnant cholesterol to predict major cardiovascular events (MACE) in patients with non-alcoholic fatt…
View article: Anti-SARS-CoV-2 antibody levels predict outcome in COVID-19 patients with type 2 diabetes: a prospective cohort study
Anti-SARS-CoV-2 antibody levels predict outcome in COVID-19 patients with type 2 diabetes: a prospective cohort study Open
View article: Coronary Event Risk Test (CERT) as a Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease
Coronary Event Risk Test (CERT) as a Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease Open
(1) Background: Ceramides are a new kind of lipid biomarker and have already been demonstrated to be valuable risk predictors in coronary patients. Patients with peripheral artery disease (PAD) are a population with a worse prognosis and h…
View article: Association between Lipid Levels, Anti-SARS-CoV-2 Spike Antibodies and COVID-19 Mortality: A Prospective Cohort Study
Association between Lipid Levels, Anti-SARS-CoV-2 Spike Antibodies and COVID-19 Mortality: A Prospective Cohort Study Open
Background: Recent studies suggest that both lipid levels and anti-severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) antibody levels are associated with outcome in coronavirus disease 2019 (COVID-19). While both parameters have …
View article: LDL-C/apoB ratio predicts future cardiovascular events in cardiovascular disease patients with nonalcoholic fatty liver disease as well as in those without nonalcoholic fatty liver disease
LDL-C/apoB ratio predicts future cardiovascular events in cardiovascular disease patients with nonalcoholic fatty liver disease as well as in those without nonalcoholic fatty liver disease Open
View article: Pro-B-type natriuretic peptide strongly predicts major cardiovascular events and mortality in cardiovascular disease patients with type 2 diabetes as well as in those without diabetes
Pro-B-type natriuretic peptide strongly predicts major cardiovascular events and mortality in cardiovascular disease patients with type 2 diabetes as well as in those without diabetes Open
View article: Ceramide-based lipid profiles and the prevalence of type 2 diabetes differ between patients with coronary artery disease and those with peripheral artery disease
Ceramide-based lipid profiles and the prevalence of type 2 diabetes differ between patients with coronary artery disease and those with peripheral artery disease Open
View article: Value of blood pressure measurement earlier versus later in life to predict cardiovascular mortality
Value of blood pressure measurement earlier versus later in life to predict cardiovascular mortality Open
View article: Cystatin C predicts major cardiovascular events in patients with coronary artery disease both among patients with type 2 diabetes and in non-diabetic individuals
Cystatin C predicts major cardiovascular events in patients with coronary artery disease both among patients with type 2 diabetes and in non-diabetic individuals Open
View article: Chronic kidney disease, type 2 diabetes and the risk of major cardiovascular events in coronary artery disease versus peripheral artery disease patients
Chronic kidney disease, type 2 diabetes and the risk of major cardiovascular events in coronary artery disease versus peripheral artery disease patients Open
View article: The A Body Shape index and type 2 diabetes are mutually independent predictors of major cardiovascular events in patients with established cardiovascular disease
The A Body Shape index and type 2 diabetes are mutually independent predictors of major cardiovascular events in patients with established cardiovascular disease Open
View article: Coronary Event Risk Test (CERT) as Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease
Coronary Event Risk Test (CERT) as Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease Open
Background:
Ceramides are a new kind of lipid biomarkers and have already been demonstrated to be valuable risk predictors in coronary patients. Patients with peripheral artery disease (PAD) are a population with worse prognosis and high…
View article: Anti-SARS-CoV2 antibody levels predict outcome in diabetic patients with COVID-19: a prospective cohort study
Anti-SARS-CoV2 antibody levels predict outcome in diabetic patients with COVID-19: a prospective cohort study Open
Diabetic patients constitute one of the most vulnerable subgroups in COVID-19. Despite high vaccination rates, a correlate of protection to advise vaccination strategies for novel SARS-CoV2 variants of concern and lower mortality in this h…
View article: Cell-free circulating RAS mutation concentrations significantly impact the survival of metastatic colorectal cancer patients
Cell-free circulating RAS mutation concentrations significantly impact the survival of metastatic colorectal cancer patients Open
View article: Supplementary Material for: Circulating glypican-4 is a predictor of 24-month overall survival in metastatic breast cancer
Supplementary Material for: Circulating glypican-4 is a predictor of 24-month overall survival in metastatic breast cancer Open
Background & objective: Endocrine treatment combined with CDK4/6 inhibitors is the preferred treatment strategy in patients presenting with ER-positive/HER2-negative breast cancer, but the clinical course remains highly variable among indi…
View article: The Value of Earlier-in-Life Systolic and Diastolic Blood Pressure for Cardiovascular Risk Prediction
The Value of Earlier-in-Life Systolic and Diastolic Blood Pressure for Cardiovascular Risk Prediction Open
View article: Circulating Glypican-4 Is a Predictor of 24-Month Overall Survival in Metastatic Breast Cancer
Circulating Glypican-4 Is a Predictor of 24-Month Overall Survival in Metastatic Breast Cancer Open
Introduction: Endocrine treatment combined with CDK4/6 inhibitors is the preferred treatment strategy in patients presenting with ER-positive/HER2-negative breast cancer, but the clinical course remains highly variable among individual pat…
View article: Circulating syndecan-1 and glypican-4 predict 12-month survival in metastatic colorectal cancer patients
Circulating syndecan-1 and glypican-4 predict 12-month survival in metastatic colorectal cancer patients Open
Cell surface syndecans and glypicans play important roles in the development and prognosis of colorectal cancer (CRC). Their soluble forms from proteoglycan shedding can be detected in blood and have been proposed as new prognostic biomark…
View article: Value of blood pressure measurement earlier versus later in life to predict cardiovascular mortality
Value of blood pressure measurement earlier versus later in life to predict cardiovascular mortality Open
Hypertension is a potent risk factor for cardiovascular morbidity and mortality. High blood pressure (BP) correlates closely with all-cause and cardiovascular mortality. The purpose of this study was to compare the value of systolic blood …