Andreas Linder
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View article: STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia
STING activation improves T-cell-engaging immunotherapy for acute myeloid leukemia Open
T-cell–recruiting bispecific antibodies (BsAbs) are in clinical development for relapsed/refractory acute myeloid leukemia (AML). Despite promising results, early clinical trials have failed to demonstrate durable responses. We investigate…
View article: <scp>STING</scp> agonism turns human T cells into interferon‐producing cells but impedes their functionality
<span>STING</span> agonism turns human T cells into interferon‐producing cells but impedes their functionality Open
View article: Field Tests for the Provision of Frequency Containment and Frequency Restoration Reserve by Variable Renewable Energy Sources Virtual Power Plants
Field Tests for the Provision of Frequency Containment and Frequency Restoration Reserve by Variable Renewable Energy Sources Virtual Power Plants Open
This paper presents the results of a series of tests on the provision of ancillary services by a Virtual Power Plant composed of variable Renewable Energy Resources. The ancillary services provided are Frequency Containment Reserve and Fre…
View article: 266 STING activation improves T cell engaging immunotherapy of acute myeloid leukemia
266 STING activation improves T cell engaging immunotherapy of acute myeloid leukemia Open
Background The treatment landscape for Acute myeloid leukemia (AML) patients has changed dramatically in recent years, however the majority of patients will eventually relapse. Allogeneic stem cell transplantation has proven the power of T…
View article: Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection Open
View article: Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses Open
CD4 + T cells are central mediators of adaptive and innate immune responses and constitute a major reservoir for human immunodeficiency virus (HIV) in vivo. Detailed investigations of resting human CD4 + T cells have been precluded by the …
View article: The patients’ perspective on the burden of idiopathic intracranial hypertension
The patients’ perspective on the burden of idiopathic intracranial hypertension Open
View article: The patients’ perspective on the burden of idiopathic intracranial Hypertension
The patients’ perspective on the burden of idiopathic intracranial Hypertension Open
Background: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaints of IIH patients,…
View article: The patients’ perspective on the burden of idiopathic intracranial hypertension
The patients’ perspective on the burden of idiopathic intracranial hypertension Open
Background: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without evidence of a tumor or any other underlying cause. Headache and visual disturbances are frequent complaints of IIH patients,…
View article: Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner Open
Replication competent vesicular stomatitis virus (VSV) is the basis of a vaccine against Ebola and VSV strains are developed as oncolytic viruses. Both functions depend on the ability of VSV to induce adequate amounts of interferon-α/β. It…
View article: Irgm2 and Gate‐16 put a break on caspase‐11 activation
Irgm2 and Gate‐16 put a break on caspase‐11 activation Open
View article: CARD8 inflammasome activation triggers pyroptosis in human T cells
CARD8 inflammasome activation triggers pyroptosis in human T cells Open
View article: TLR8 Is a Sensor of RNase T2 Degradation Products
TLR8 Is a Sensor of RNase T2 Degradation Products Open
View article: Mitochondrial dsRNA: A New DAMP for MDA5
Mitochondrial dsRNA: A New DAMP for MDA5 Open
View article: Charakterisierung der Liganden von retinoic acid inducible gene I in Vesicular-stomatitis-Virus-infizierten Zellen
Charakterisierung der Liganden von retinoic acid inducible gene I in Vesicular-stomatitis-Virus-infizierten Zellen Open