Andreas Machens
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View article: 30 Jahre prophylaktische Thyreoidektomie beim hereditären medullären Schilddrüsenkarzinom
30 Jahre prophylaktische Thyreoidektomie beim hereditären medullären Schilddrüsenkarzinom Open
View article: Latest Progress in Risk-Adapted Surgery for Medullary Thyroid Cancer
Latest Progress in Risk-Adapted Surgery for Medullary Thyroid Cancer Open
(1) Background: The wider adoption of a preoperative ultrasound and calcitonin screening complemented by an intraoperative frozen section has increased the number of patients with occult sporadic medullary thyroid cancer (MTC). These advan…
View article: The Changing Face of Multiple Endocrine Neoplasia 2A: From Symptom-Based to Preventative Medicine
The Changing Face of Multiple Endocrine Neoplasia 2A: From Symptom-Based to Preventative Medicine Open
Context Early genetic association studies yielded too high risk estimates for multiple endocrine neoplasia (MEN2A), suggesting a need for extended surgery. Objective The objective was to delineate temporal changes in MEN2A presentation by …
View article: Temporal trends in referrals of RET gene carriers for neck surgery to a tertiary surgical center in the era of international management guidelines
Temporal trends in referrals of RET gene carriers for neck surgery to a tertiary surgical center in the era of international management guidelines Open
View article: Risk Patterns of Distant Metastases in Follicular, Papillary and Medullary Thyroid Cancer
Risk Patterns of Distant Metastases in Follicular, Papillary and Medullary Thyroid Cancer Open
This study of 542 patients with follicular thyroid cancer, 366 patients with the follicular variant and 1452 patients with the classical variant of papillary thyroid cancer, and 819 patients with sporadic medullary thyroid cancer operated …
View article: Metastatic Risk Profile of Microscopic Lymphatic and Venous Invasion in Medullary Thyroid Cancer
Metastatic Risk Profile of Microscopic Lymphatic and Venous Invasion in Medullary Thyroid Cancer Open
The metastatic risk profile of microscopic lymphatic and venous invasion in medullary thyroid cancer is ill-defined. This evidence gap calls for evaluation of the suitability of microscopic lymphatic and venous invasion at thyroidectomy fo…
View article: Recurrent Laryngeal Nerve Preservation Strategies in Pediatric Thyroid Oncology: Continuous vs. Intermittent Nerve Monitoring
Recurrent Laryngeal Nerve Preservation Strategies in Pediatric Thyroid Oncology: Continuous vs. Intermittent Nerve Monitoring Open
(1) Background: Pediatric thyroidectomy is characterized by considerable space constraints, thinner nerves, a large thymus, and enlarged neck nodes, compromising surgical exposure. Given these challenges, risk-reduction surgery is of param…
View article: Exceptionality of Distant Metastasis in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned
Exceptionality of Distant Metastasis in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned Open
Context Risk factors of lymph node and distant metastases have rarely been analyzed in hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data sets. Objective This comprehensive investigation aimed to explo…
View article: Prediction of biochemical cure in patients with medullary thyroid cancer
Prediction of biochemical cure in patients with medullary thyroid cancer Open
Background The impact of number of node metastases versus metastatic lymph node ratio versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not well defined. Methods Multivariable logistic regression analysis w…
View article: Intraoperative nerve monitoring in thyroid surgery—shifting current paradigms
Intraoperative nerve monitoring in thyroid surgery—shifting current paradigms Open
Over the past two decades, intraoperative neural monitoring (IONM) has matured into a powerful risk minimization tool. Meta-analyses of studies, most of which were limited by poor study designs and the sole use of intermittent nerve stimul…
View article: Clinical Presentation, Treatment and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study
Clinical Presentation, Treatment and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study Open
View article: Time to calcitonin normalization after surgery for node-negative and node-positive medullary thyroid cancer
Time to calcitonin normalization after surgery for node-negative and node-positive medullary thyroid cancer Open
Background It remains unclear when postoperative serum calcitonin levels should be measured in patients with medullary thyroid cancer (MTC) and, specifically, whether this decision should be based on the preoperative calcitonin level or no…
View article: Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study
Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study Open
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View article: Evolution and progress of continuous intraoperative neural monitoring
Evolution and progress of continuous intraoperative neural monitoring Open
Electrophysiological nerve mapping and monitoring devices have been forthcoming since the 1970s, facilitating intraoperative identification and functional checks of recurrent laryngeal nerve (RLN) function during neck surgery. Although the…
View article: Prediction of Postoperative Vocal Fold Function After Intraoperative Recovery of Loss of Signal
Prediction of Postoperative Vocal Fold Function After Intraoperative Recovery of Loss of Signal Open
Objectives/Hypothesis This multicenter study aimed to 1) evaluate early postoperative vocal fold function in relation to intraoperative amplitude recovery, and 2) determine optimal absolute and relative thresholds of intraoperative amplitu…
View article: Letter to the Editor: “p.Val804Met, the Most Frequent Pathogenic Mutation in RET, Confers a Very Low Lifetime Risk of Medullary Thyroid Cancer”
Letter to the Editor: “p.Val804Met, the Most Frequent Pathogenic Mutation in RET, Confers a Very Low Lifetime Risk of Medullary Thyroid Cancer” Open
View article: Issue Information
Issue Information Open
View article: Geographic epidemiology of medullary thyroid cancer families: unearthing European ancestral heritage
Geographic epidemiology of medullary thyroid cancer families: unearthing European ancestral heritage Open
View article: Long-Term Survivorship in Multiple Endocrine Neoplasia Type 2B Diagnosed Before and in the New Millennium
Long-Term Survivorship in Multiple Endocrine Neoplasia Type 2B Diagnosed Before and in the New Millennium Open
Context Recent long-term outcomes and survival data are lacking for patients with multiple endocrine neoplasia type 2B (MEN2B). Objectives To analyze long-term MEN2B outcomes and define prognostic factors. Design, Setting, and Participants…
View article: Opportunities and challenges of intermittent and continuous intraoperative neural monitoring in thyroid surgery
Opportunities and challenges of intermittent and continuous intraoperative neural monitoring in thyroid surgery Open
The number of thyroid operations and there radically continues to rise in the western hemisphere, bringing prevention of recurrent laryngeal nerve (RLN) palsy to the fore. Overall, the incidence of RLN palsy is fairly low but continues to …
View article: Advances in risk-oriented surgery for multiple endocrine neoplasia type 2
Advances in risk-oriented surgery for multiple endocrine neoplasia type 2 Open
Genetic association studies hinge on definite clinical case definitions of the disease of interest. This is why more penetrant mutations were overrepresented in early multiple endocrine neoplasia type 2 (MEN2) studies, whereas less penetra…
View article: Continuous intraoperative neural monitoring of the recurrent nerves in thyroid surgery: a quantum leap in technology
Continuous intraoperative neural monitoring of the recurrent nerves in thyroid surgery: a quantum leap in technology Open
The continuous intraoperative neural monitoring (CIONM) technique is increasingly acknowledged as a useful tool to recognize impending nerve injury and to abort the related manoeuvre to prevent nerve injury during thyroid surgery. CIONM pr…
View article: Surgical cure rates of sporadic medullary thyroid cancer in the era of calcitonin screening
Surgical cure rates of sporadic medullary thyroid cancer in the era of calcitonin screening Open
Objective Time trends of the extent of disease at first diagnosis and biochemical cure remain ill-defined for sporadic medullary thyroid cancer (MTC). This investigation aimed to delineate time trends and biochemical cure rates for sporadi…
View article: Prospective study of vocal fold function after loss of the neuromonitoring signal in thyroid surgery: The <scp>I</scp>nternational <scp>N</scp>eural <scp>M</scp>onitoring <scp>S</scp>tudy <scp>G</scp>roup's <scp>POLT</scp> study
Prospective study of vocal fold function after loss of the neuromonitoring signal in thyroid surgery: The <span>I</span>nternational <span>N</span>eural <span>M</span>onitoring <span>S</span>tudy <span>G</span>roup's <span>POLT</span> study Open
Objectives/Hypothesis Intraoperative neuromonitoring identifies recurrent laryngeal nerve (RLN) injury and gives prognostic information regarding postoperative glottic function. Loss of the neuromonitoring signal (LOS) signifies segmental …
View article: Postoperative vocal fold palsy in patients undergoing thyroid surgery with continuous or intermittent nerve monitoring
Postoperative vocal fold palsy in patients undergoing thyroid surgery with continuous or intermittent nerve monitoring Open
Background Continuous monitoring of electromyographic (EMG) amplitudes of the vocal muscles detects impending injury of the recurrent laryngeal nerve (RLN) during thyroid operations earlier than intermittent EMG monitoring. This may alert …
View article: Therapeutic Effectiveness of Screening for Multiple Endocrine Neoplasia Type 2A
Therapeutic Effectiveness of Screening for Multiple Endocrine Neoplasia Type 2A Open
Screening efforts need to focus on sporadic-appearing MTC to deplete the pool of unrecognized carriers of ATA level B and A mutations and enable earlier pre-emptive thyroidectomy in their offspring.
View article: Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma
Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma Open
The Task Force developed 67 evidence-based recommendations to assist clinicians in the care of patients with MTC. The Task Force considers the recommendations to represent current, rational, and optimal medical practice.