Andreas Mayr
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View article: Letter to the editor refuting “Debunking the GAMLSS myth: Simplicity reigns in pulmonary function diagnostics”
Letter to the editor refuting “Debunking the GAMLSS myth: Simplicity reigns in pulmonary function diagnostics” Open
View article: Ultra-fast extubation following cardiac surgery improves hemodynamic stability and reduces ICU workload
Ultra-fast extubation following cardiac surgery improves hemodynamic stability and reduces ICU workload Open
Objective To address ICU capacity constraints, particularly during the COVID-19 pandemic, we implemented an ultrafast extubation (UFE) protocol involving operating room extubation (ORE) following on-pump cardiac surgery. We hypothesize tha…
View article: The Influence of Anesthesiologist Gender and Experience on Risk Understanding and Anxiety Changes After Online Preoperative Patient Education: A Sub-Analysis of the iPREDICT Randomized Controlled Trial
The Influence of Anesthesiologist Gender and Experience on Risk Understanding and Anxiety Changes After Online Preoperative Patient Education: A Sub-Analysis of the iPREDICT Randomized Controlled Trial Open
Background/Objectives: Digital health technologies are increasingly integrated into perioperative care to standardize information delivery and improve patient empowerment. However, the overall effectiveness of preoperative education depend…
View article: Perceptions, Usage, and Educational Impact of ChatGPT Among Medical Students in Germany: Cross-Sectional Mixed Methods Survey
Perceptions, Usage, and Educational Impact of ChatGPT Among Medical Students in Germany: Cross-Sectional Mixed Methods Survey Open
Background Large language models such as ChatGPT offer significant opportunities for medical education. However, empirical data on actual usage patterns, perceived benefits, and limitations among medical students remain limited. Objective …
View article: Utilization of High Frequency Induction Heating for the Reduction of Wrinkle Defects in the Calendaring Process of Lithium-Ion Batteries
Utilization of High Frequency Induction Heating for the Reduction of Wrinkle Defects in the Calendaring Process of Lithium-Ion Batteries Open
Lithium-ion battery (LIB) production currently faces increasing demands for lower cost, higher energy density, and improved safety, necessitating the development of processes optimized for both throughput and quality. In electrode producti…
View article: Modelling dependent censoring in time-to-event data using boosting copula regression
Modelling dependent censoring in time-to-event data using boosting copula regression Open
View article: Detecting gene-environment interactions to guide personalized intervention: boosting distributional regression for polygenic scores
Detecting gene-environment interactions to guide personalized intervention: boosting distributional regression for polygenic scores Open
Polygenic risk scores can be used to model the individual genetic liability for human traits. Current methods primarily focus on modeling the mean of a phenotype neglecting the variance. However, genetic variants associated with phenotypic…
View article: Multivariate Trajectories of Weight and Mental Health and Their Prognostic Significance 6 Years After Obesity Surgery
Multivariate Trajectories of Weight and Mental Health and Their Prognostic Significance 6 Years After Obesity Surgery Open
Objective Obesity surgery (OS) results in substantial, albeit heterogeneous, long‐term improvements in weight and mental health, with unclear trajectories and their associations. This study examined multivariate trajectories of weight, psy…
View article: Prevalence of locoregional and distant lymph node metastases in children and adolescents/young adults with soft tissue sarcomas: a Bayesian meta-analysis of proportions
Prevalence of locoregional and distant lymph node metastases in children and adolescents/young adults with soft tissue sarcomas: a Bayesian meta-analysis of proportions Open
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View article: Enhanced Variable Selection for Boosting Sparser and Less Complex Models in Distributional Copula Regression
Enhanced Variable Selection for Boosting Sparser and Less Complex Models in Distributional Copula Regression Open
Structured additive distributional copula regression allows to model the joint distribution of multivariate outcomes by relating all distribution parameters to covariates. Estimation via statistical boosting enables accounting for high-dim…
View article: A balanced statistical boosting approach for GAMLSS via new step lengths
A balanced statistical boosting approach for GAMLSS via new step lengths Open
Component-wise gradient boosting algorithms are popular for their intrinsic variable selection and implicit regularization, which can be especially beneficial for very flexible model classes. When estimating generalized additive models for…
View article: The impact of preexisting omega-3 fatty acid serum levels on outcomes following out-of-hospital cardiac arrest: A comprehensive investigation
The impact of preexisting omega-3 fatty acid serum levels on outcomes following out-of-hospital cardiac arrest: A comprehensive investigation Open
This study demonstrates a significant association between preexisting PUFA serum levels during OHCA and long-term outcomes following ROSC, highlighting their potential cardio- and neuroprotective roles. These findings underscore the need f…
View article: Mechanisms of Change in Cognitive‐Behavioral Therapy for Adults With Binge‐Eating Disorder: A Dynamic Structural Equation Modeling Approach
Mechanisms of Change in Cognitive‐Behavioral Therapy for Adults With Binge‐Eating Disorder: A Dynamic Structural Equation Modeling Approach Open
Objective Cognitive‐behavioral therapy (CBT) is the most well‐established treatment for binge‐eating disorder (BED), but the mechanisms of change remain poorly understood. This study investigated in CBT for BED the effects of overvaluation…
View article: Improved Perioperative Risk Education Through the Use of an Interactive Online Anaesthesia Education Tool (iPREDICT): A Prospective, Randomised Controlled Single-Centre Clinical Trial
Improved Perioperative Risk Education Through the Use of an Interactive Online Anaesthesia Education Tool (iPREDICT): A Prospective, Randomised Controlled Single-Centre Clinical Trial Open
Background/Objectives: Involving patients in the preoperative anaesthetic assessment (PAA) process can improve their understanding of risks and contribute to better postoperative recovery and outcomes. The iPREDICT study aims to investigat…
View article: Boosting distributional copula regression for bivariate binary, discrete and mixed responses
Boosting distributional copula regression for bivariate binary, discrete and mixed responses Open
Motivated by challenges in the analysis of biomedical data and observational studies, we develop statistical boosting for the general class of bivariate distributional copula regression with arbitrary marginal distributions, which is suite…
View article: Boosting Distributional Copula Regression for Bivariate Right-Censored Time-to-Event Data
Boosting Distributional Copula Regression for Bivariate Right-Censored Time-to-Event Data Open
We propose a highly flexible distributional copula regression model for bivariate time-to-event data in the presence of right-censoring. The joint survival function of the response is constructed using parametric copulas, allowing for a se…
View article: Differences between Current Clinical Practice and Evidence-Based Guideline Recommendations Regarding Tocolysis – an Austria-wide Survey
Differences between Current Clinical Practice and Evidence-Based Guideline Recommendations Regarding Tocolysis – an Austria-wide Survey Open
To evaluate the adherence of Austrian obstetricians to national guideline recommendations by investigating data on the current practice of tocolysis regarding indications, timing and monitoring of tocolysis, choice of tocolytics and seriou…
View article: Cerebral Overperfusion Despite Reduced Cortical Metabolism Is Associated with Postoperative Delirium in Cardiac Surgery Patients: A Prospective Observational Study
Cerebral Overperfusion Despite Reduced Cortical Metabolism Is Associated with Postoperative Delirium in Cardiac Surgery Patients: A Prospective Observational Study Open
Background: Decreased cerebral oximetry (rSO2) in cardiac surgery is associated with postoperative delirium (POD). However, interventions optimizing intraoperative rSO2 are inconclusive. Methods: In this prospective observational cohort st…
View article: Genetic Prediction Modeling in Large Cohort Studies via Boosting Targeted Loss Functions
Genetic Prediction Modeling in Large Cohort Studies via Boosting Targeted Loss Functions Open
Polygenic risk scores (PRS) aim to predict a trait from genetic information, relying on common genetic variants with low to medium effect sizes. As genotype data are high‐dimensional in nature, it is crucial to develop methods that can be …
View article: Ranking evaluation metrics from a group-theoretic perspective
Ranking evaluation metrics from a group-theoretic perspective Open
Confronted with the challenge of identifying the most suitable metric to validate the merits of newly proposed models, the decision-making process is anything but straightforward. Given that comparing rankings introduces its own set of for…
View article: Transferability of polygenic risk scores depending on demography and dominance coefficients
Transferability of polygenic risk scores depending on demography and dominance coefficients Open
The genetic liability to a complex phenotype is calculated as the sum of genotypes, weighted by effect size estimates derived from summary statistics of genome-wide association study (GWAS) data. Due to different allele frequencies (AF) an…
View article: Enhanced variable selection for boosting sparser and less complex models in distributional copula regression
Enhanced variable selection for boosting sparser and less complex models in distributional copula regression Open
Structured additive distributional copula regression allows to model the joint distribution of multivariate outcomes by relating all distribution parameters to covariates. Estimation via statistical boosting enables accounting for high-dim…
View article: Generalizability of polygenic prediction models: how is the R2 defined on test data?
Generalizability of polygenic prediction models: how is the R2 defined on test data? Open
View article: A Balanced Statistical Boosting Approach for GAMLSS via New Step Lengths
A Balanced Statistical Boosting Approach for GAMLSS via New Step Lengths Open
Component-wise gradient boosting algorithms are popular for their intrinsic variable selection and implicit regularization, which can be especially beneficial for very flexible model classes. When estimating generalized additive models for…
View article: VN-EGNN: E(3)-Equivariant Graph Neural Networks with Virtual Nodes Enhance Protein Binding Site Identification
VN-EGNN: E(3)-Equivariant Graph Neural Networks with Virtual Nodes Enhance Protein Binding Site Identification Open
Being able to identify regions within or around proteins, to which ligands can potentially bind, is an essential step to develop new drugs. Binding site identification methods can now profit from the availability of large amounts of 3D str…
View article: Boosting Distributional Copula Regression for Bivariate Binary, Discrete and Mixed Responses
Boosting Distributional Copula Regression for Bivariate Binary, Discrete and Mixed Responses Open
Motivated by challenges in the analysis of biomedical data and observational studies, we develop statistical boosting for the general class of bivariate distributional copula regression with arbitrary marginal distributions, which is suite…
View article: Editorial
Editorial Open
View article: PROPDESC-Score-Validierung (PROPDESC-Val)
PROPDESC-Score-Validierung (PROPDESC-Val) Open
View article: Online Compassion Focused Therapy for overeating: Feasibility and acceptability pilot study
Online Compassion Focused Therapy for overeating: Feasibility and acceptability pilot study Open
Objective This pilot study aims to investigate the feasibility, acceptability, and potential effectiveness of online Compassion Focused Therapy for overeating (CFT‐OE). Method Eighteen Portuguese women seeking treatment for overeating were…
View article: Comparison of the Diode Laser Wavelengths 445 nm and 810 nm in Gingival Depigmentation – A Clinical Evaluation
Comparison of the Diode Laser Wavelengths 445 nm and 810 nm in Gingival Depigmentation – A Clinical Evaluation Open
Introduction: Nowadays, esthetic appearance plays an important role in the field of dentistry. Discolorations and pigmentations of the gingiva reduce the appearance of a healthy-looking smile. On this occasion, the use of lasers shows a pr…