Andreas Melzer
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View article: Development and application of a structured preclinical protocol for MRI-guided endomyocardial biopsy: a multimodal imaging approach using a hybrid vessel phantom and porcine in vivo models
Development and application of a structured preclinical protocol for MRI-guided endomyocardial biopsy: a multimodal imaging approach using a hybrid vessel phantom and porcine in vivo models Open
The developed preclinical testing protocol effectively evaluated key device characteristics (reliable visibility, handling, and accurate tissue sampling) of the MR-compatible EMB forceps, providing valuable insights in the early stages of …
View article: Design and Validation of Silicone-Based Stenosis Vessel Segments for MRI Vascular Phantoms
Design and Validation of Silicone-Based Stenosis Vessel Segments for MRI Vascular Phantoms Open
Background To support the development of MRI-guided interventions for aortic coarctation, a modular polymer-based vessel phantom with interchangeable stenosis segments was developed. This study focuses on the design and mechanical evaluati…
View article: Preclinical Evaluation of an MR Conditional Forceps for MRI-Guided Endomyocardial Biopsy: A Multimodal Imaging Approach Using a Hybrid Vessel Phantom and Porcine In Vivo Models
Preclinical Evaluation of an MR Conditional Forceps for MRI-Guided Endomyocardial Biopsy: A Multimodal Imaging Approach Using a Hybrid Vessel Phantom and Porcine In Vivo Models Open
Background MRI-guided cardiovascular procedures provide high-resolution, radiation-free imaging, but clinical translation is limited due to the lack of MR Conditional medical devices. This study presents a structured preclinical approach f…
View article: Effects of skull properties on continuous-wave transcranial focused ultrasound transmission
Effects of skull properties on continuous-wave transcranial focused ultrasound transmission Open
Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through the skull introduces significant wave interactions, compl…
View article: Versatile High-Throughput Platform for Focused Ultrasound In Vitro Application
Versatile High-Throughput Platform for Focused Ultrasound In Vitro Application Open
For the more efficient application of ultrasound in future therapies, fundamental research is needed on the mode of action of ultrasound on biological systems using therapeutic frequencies. To address this need, a new versatile high-throug…
View article: Aerosol Particle Spreading in an Operation Room under Dynamic Condition
Aerosol Particle Spreading in an Operation Room under Dynamic Condition Open
We report on the experimental investigation of aerosol particle spreading in an operation room. Different configurations regarding the source position or representative movements of the staff in the room are analyzed. The data acquisition …
View article: Surgical Hyperspectral imaging and Indocyanine green Near-infrared Examination (SHINE) for brain arteriovenous malformation resection: a case report on how to visualize perfusion
Surgical Hyperspectral imaging and Indocyanine green Near-infrared Examination (SHINE) for brain arteriovenous malformation resection: a case report on how to visualize perfusion Open
Background and importance Arteriovenous malformations (AVMs) are complex vascular anomalies that pose significant risks, including intracranial hemorrhage and neurological deficits. Surgical resection is the preferred treatment, requiring …
View article: Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures
Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures Open
Introduction: Image-guided invasive procedures on the liver require a steep learning curve to acquire the necessary skills. The best and safest way to achieve these skills is through hands-on courses that include simulations and phantoms o…
View article: Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach
Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach Open
Background: Patients with liver pathology benefit from image-guided interventions. Training for interventional procedures is recommended to be performed on liver phantoms until a basic proficiency is reached. In the last 40 years, several …
View article: Effects of skull properties on long-pulsed transcranial focused ultrasound transmission
Effects of skull properties on long-pulsed transcranial focused ultrasound transmission Open
Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through the skull introduces significant wave interactions, compl…
View article: Switchable LED-based laparoscopic multispectral system for rapid high-resolution perfusion imaging
Switchable LED-based laparoscopic multispectral system for rapid high-resolution perfusion imaging Open
High-resolution perfusion monitoring was successfully achieved. Hardware optimizations will increase the frame rate. Parameter optimizations through alternative illumination patterns, regression, or assumed tissue models are planned. Intra…
View article: In memoriam: Joachim Kettenbach (1960–2023)
In memoriam: Joachim Kettenbach (1960–2023) Open
graduated from the Medical University of Graz/ Austria in 1985.After accomplishing the obligatory clinical residence phase, he started a specialized training in Radiology at the Medical University of Vienna/ Austria from 1991 to 1996.Durin…
View article: Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma
Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma Open
Background Sonodynamic therapy (SDT) is currently on critical path for glioblastoma therapeutics. However, the molecular mechanisms underlying the therapeutic functions of SDT remain enigmatic due to the lack of intricately optimised instr…
View article: 3D motion corrupted PET/MRI phantom raw data
3D motion corrupted PET/MRI phantom raw data Open
The measurements were all performed on a PET/MRI system from Siemens Healthineers AG (Biograph mMR). An MR-compatible robotic system was used to generate rigid movements of a head-like phantom (translational and more comlpex motion pattern…
View article: 3D motion corrupted PET/MRI phantom raw data
3D motion corrupted PET/MRI phantom raw data Open
The measurements were all performed on a PET/MRI system from Siemens Healthineers AG (Biograph mMR). An MR-compatible robotic system was used to generate rigid movements of a head-like phantom (translational and more comlpex motion pattern…
View article: Ultrasound-induced cavitation renders prostate cancer cells susceptible to hyperthermia: Analysis of potential cellular and molecular mechanisms
Ultrasound-induced cavitation renders prostate cancer cells susceptible to hyperthermia: Analysis of potential cellular and molecular mechanisms Open
Background: Focused ultrasound (FUS) has become an important non-invasive therapy for prostate tumor ablation via thermal effects in the clinic. The cavitation effect induced by FUS is applied for histotripsy, support drug delivery, and th…
View article: Evaluation of a Developed MRI-Guided Focused Ultrasound System in 7 T Small Animal MRI and Proof-of-Concept in a Prostate Cancer Xenograft Model to Improve Radiation Therapy
Evaluation of a Developed MRI-Guided Focused Ultrasound System in 7 T Small Animal MRI and Proof-of-Concept in a Prostate Cancer Xenograft Model to Improve Radiation Therapy Open
Focused ultrasound (FUS) can be used to physiologically change or destroy tissue in a non-invasive way. A few commercial systems have clinical approval for the thermal ablation of solid tumors for the treatment of neurological diseases and…
View article: Alternative intraoperative optical imaging modalities for fluorescence angiography in gastrointestinal surgery: spectral imaging and imaging photoplethysmography
Alternative intraoperative optical imaging modalities for fluorescence angiography in gastrointestinal surgery: spectral imaging and imaging photoplethysmography Open
Non-invasive spectral imaging and iPPG have shown promising results in gastrointestinal surgery. They can overcome the main drawbacks of ICG-FA, i.e. the use of contrast agents, the lack of quantitative analysis, repeatability, and a diffi…
View article: Spectral Similarity Measures for In Vivo Human Tissue Discrimination Based on Hyperspectral Imaging
Spectral Similarity Measures for In Vivo Human Tissue Discrimination Based on Hyperspectral Imaging Open
Problem: Similarity measures are widely used as an approved method for spectral discrimination or identification with their applications in different areas of scientific research. Even though a range of works have been presented, only a fe…
View article: Design and validation of a medical robotic device system to control two collaborative robots for ultrasound-guided needle insertions
Design and validation of a medical robotic device system to control two collaborative robots for ultrasound-guided needle insertions Open
The percutaneous biopsy is a critical intervention for diagnosis and staging in cancer therapy. Robotic systems can improve the efficiency and outcome of such procedures while alleviating stress for physicians and patients. However, the hi…
View article: Hybrid polymer vessel phantoms for feasibility studies and clinical training of MRI-guided interventions
Hybrid polymer vessel phantoms for feasibility studies and clinical training of MRI-guided interventions Open
Development of novel MRI-guided medical procedures including medical devices, catheters and workflows, state the need of extensive testing.Goal of this study is to show the manufacturing process of polymer based vessel phantoms for perform…
View article: Focused Ultrasound Treatment of a Spheroid In Vitro Tumour Model
Focused Ultrasound Treatment of a Spheroid In Vitro Tumour Model Open
Focused ultrasound (FUS) is a non-invasive technique producing a variety of biological effects by either thermal or mechanical mechanisms of ultrasound interaction with the targeted tissue. FUS could bring benefits, e.g., tumour sensitisat…
View article: Combined indocyanine green and quantitative perfusion assessment with hyperspectral imaging during colorectal resections
Combined indocyanine green and quantitative perfusion assessment with hyperspectral imaging during colorectal resections Open
Anastomotic insufficiencies still represent one of the most severe complications in colorectal surgery. Since tissue perfusion highly affects anastomotic healing, its objective assessment is an unmet clinical need. Indocyanine green-based …