Andreas Möller
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View article: The (in)Significance of Establishing Accurate Extracellular Vesicle Nomenclature
The (in)Significance of Establishing Accurate Extracellular Vesicle Nomenclature Open
View article: Regenerative restoration of chronic obstructive pulmonary disease by human umbilical cord blood small extracellular vesicles
Regenerative restoration of chronic obstructive pulmonary disease by human umbilical cord blood small extracellular vesicles Open
Chronic obstructive pulmonary disease (COPD) is a leading cause of death and morbidity, and the inability of current treatments to repair lung damage creates an urgent need for novel regenerative therapies. Human umbilical cord blood small…
View article: The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease
The hepatic transcriptome is differentially regulated by a standardized meal in healthy individuals compared to patients with fatty liver disease Open
The human liver is dynamic organ with minute to hourly adaptions in response to feeding. Patients with non-alcoholic fatty liver disease (NAFLD) and cirrhosis have altered transcriptomic features compared to controls but how and if food in…
View article: Glycan Profiling in Small Extracellular Vesicles with a SERS Microfluidic Biosensor Identifies Early Malignant Development in Lung Cancer (Adv. Sci. 33/2024)
Glycan Profiling in Small Extracellular Vesicles with a SERS Microfluidic Biosensor Identifies Early Malignant Development in Lung Cancer (Adv. Sci. 33/2024) Open
Non‐Small Cell Lung Cancer In article number 2401818, Alain Wuethrich, Richard J. Lobb, Matt Trau, and co‐workers develop a surface‐enhanced Raman scattering (SERS) assay for detecting glycan signatures in extracellular vesicles (EVs) of e…
View article: Glycan Profiling in Small Extracellular Vesicles with a SERS Microfluidic Biosensor Identifies Early Malignant Development in Lung Cancer
Glycan Profiling in Small Extracellular Vesicles with a SERS Microfluidic Biosensor Identifies Early Malignant Development in Lung Cancer Open
Glycosylation is the most common post‐translational modification of proteins and regulates a myriad of fundamental biological processes under normal, and pathological conditions. Altered protein glycosylation is linked to malignant transfo…
View article: Immune Regulation and Immune Therapy in Melanoma: Review with Emphasis on CD155 Signalling
Immune Regulation and Immune Therapy in Melanoma: Review with Emphasis on CD155 Signalling Open
Melanoma is commonly diagnosed in a younger population than most other solid malignancies and, in Australia and most of the world, is the leading cause of skin-cancer-related death. Melanoma is a cancer type with high immunogenicity; thus,…
View article: Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers
Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers Open
Breast cancer is a leading cause of death in women, and its management highly depends on early disease diagnosis and monitoring. This remains challenging due to breast cancer's heterogeneity and a scarcity of specific biomarkers that could…
View article: A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells
A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells Open
Immune checkpoint proteins (ICPs) play a major role in a patient's immune response against cancer. Tumour cells usually express those proteins to communicate with immune cells as a process of escaping the anti-cancer immune response. Detec…
View article: Optimal isolation of extracellular vesicles from pleural fluid and profiling of their microRNA cargo
Optimal isolation of extracellular vesicles from pleural fluid and profiling of their microRNA cargo Open
Pleural effusion occurs in both benign and malignant pleural disease. In malignant pleural effusions, the diagnostic accuracy and sensitivity of pleural fluid cytology is less than perfect, particularly for the diagnosis of malignant pleur…
View article: Method optimisation to enrich small extracellular vesicles from saliva samples
Method optimisation to enrich small extracellular vesicles from saliva samples Open
Salivary small extracellular vesicles (sEV) contain cancer-derived biomolecules, and sEVs can mediate cancer progression and metastasis.1 Given their biological roles during cancer pathogenesis,2 sEVs can be used as non-invasive markers fo…
View article: A Microfluidic Liquid Biopsy Platform to Monitor Protein Biomarker Heterogeneity in Single Circulating Therapy‐Resistance Cancer Cell
A Microfluidic Liquid Biopsy Platform to Monitor Protein Biomarker Heterogeneity in Single Circulating Therapy‐Resistance Cancer Cell Open
Tumor cells display heterogenous molecular signatures during the course of cancer and create distinct tumor cell subpopulations which challenge effective therapeutic decisions. Detection and monitoring of these heterogenous molecular event…
View article: Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus Open
Extracellular vesicles (EVs) are messengers that carry information in the form of proteins, lipids, and nucleic acids and are not only essential for intercellular communication but also play a critical role in the progression of various pa…
View article: Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
View article: Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Loss of hematopoietic Ifnar1 reduces metastasis-free survival in the 4T1.2 model.
View article: Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
IL-2 stimulated NK cells derived from Ifnar1-/- or WT mice have comparable cytotoxicity against syngeneic breast tumor lines.
View article: Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Anti-proliferative effects and production of type-I IFN by balb/c syngeneic breast tumor cell lines.
View article: Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Metastatic progression is the major cause of breast cancer–related mortality. By examining multiple syngeneic preclinical breast cancer models in mice lacking a functional type-I interferon receptor (Ifnar1−/− mice), we show tha…
View article: Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Immune suppressor cell and T lymphocyte accumulation in the peripheral blood of WT and Ifnar1-/- mice.
View article: Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Anti-proliferative effects and production of type-I IFN by balb/c syngeneic breast tumor cell lines.
View article: Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
View article: Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Metastatic progression is the major cause of breast cancer–related mortality. By examining multiple syngeneic preclinical breast cancer models in mice lacking a functional type-I interferon receptor (Ifnar1−/− mice), we show tha…
View article: Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Immune suppressor cell and T lymphocyte accumulation in the peripheral blood of WT and Ifnar1-/- mice.
View article: Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
IL-2 stimulated NK cells derived from Ifnar1-/- or WT mice have comparable cytotoxicity against syngeneic breast tumor lines.
View article: Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer
Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer Open
Loss of hematopoietic Ifnar1 reduces metastasis-free survival in the 4T1.2 model.
View article: Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Supplementary Figure S4. Acute impact of EO771 breast cancer exosomes on immune microenvironment in the lung. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
C57BL/6 mice received a single intravenous injection of EO771-derived exosomes (50 µg/mouse; 4E11 particles) or liposomes. Immune composition changes in the lung was assessed 24-hours later by flow cytometry. Frequency of (A) myeloid cells…
View article: Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Data from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes Open
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the tumor microenvironment. Here, we use optical imaging to determine that exogenously a…
View article: Supplementary Figure 3 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues
Supplementary Figure 3 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues Open
Changes in exosome concentration in individual patients (particles per mL) over course of treatment.
View article: Data from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues
Data from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues Open
Purpose: To study the response of irradiated and out-of-field normal tissues during localized curative intent radiotherapy.Experimental Design: Sixteen patients with non–small cell lung carcinoma (NSCLC) received 60 Gy in 30 …
View article: Supplementary Figure 2 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues
Supplementary Figure 2 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues Open
Mean (+/- SD) Changes in concentration of plasma cytokine levels at baseline, 1-hour, 24-hours and 4-weeks after commencement of RT stratified by use of concurrent chemotherapy. Change at 1-hour in MDC and 4 weeks in MIP-1α is marked with …
View article: Supplementary Figure 3 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues
Supplementary Figure 3 from Radiotherapy for Non–Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues Open
Changes in exosome concentration in individual patients (particles per mL) over course of treatment.