Andreas Muschaweckh
YOU?
Author Swipe
View article: B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 Open
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen 1 . The immunopathology in neuromyelitis optica is largely driven by autoantibodies to A…
View article: IL-23 stabilizes an effector Treg cell program in the tumor microenvironment
IL-23 stabilizes an effector Treg cell program in the tumor microenvironment Open
View article: Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity Open
Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1 TBM/TBM (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms are unknow…
View article: Evaluation of the Effect of CD70 Co-Expression on CD8 T Cell Response in Protein-Prime MVA-Boost Vaccination in Mice
Evaluation of the Effect of CD70 Co-Expression on CD8 T Cell Response in Protein-Prime MVA-Boost Vaccination in Mice Open
Here, we investigate the potential of CD70 co-expression during viral vector boost vaccination to improve an antigen-specific T cell response. To determine the chance of activating antigen-specific T cells by CD70, we used the HBV core ant…
View article: IL-24 intrinsically regulates Th17 cell pathogenicity in mice
IL-24 intrinsically regulates Th17 cell pathogenicity in mice Open
In certain instances, Th17 responses are associated with severe immunopathology. T cell–intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 responses but are less well studied for Th17 cell…
View article: Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation
Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation Open
BCL10/MALT1 signaling in keratinocytes is altered in human sporadic psoriasis and is a critical initiator and amplifier of skin inflammation in mouse models.
View article: Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity Open
View article: A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control Open
View article: Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments
Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments Open
Foxp3+ Treg cells are indispensable for maintaining self-tolerance in secondary lymphoid organs (SLOs). However, Treg cells are also recruited to non-lymphoid tissues (NLTs) during inflammation. Recent advances in the understand…
View article: Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation Open
View article: IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122− γδ T Cells to γδT17 Cells
IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122− γδ T Cells to γδT17 Cells Open
γδT17 cells are a subset of γδ T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. γδT17 cells are believed to arise within a narrow time window during prenatal thym…
View article: Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells Open
Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tiss…
View article: Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection Open
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune cells and providing bystander activation. Here, we characterize the functioning of …
View article: Characterization of tissue-resident CD8+ T cell memory formation upon skin infection with the viral vector MVA
Characterization of tissue-resident CD8+ T cell memory formation upon skin infection with the viral vector MVA Open
Tissue-resident memory (TRM) cells are cytotoxic CD8+ T cells that populate the epithelia of non-lymphoid organs and mediate rapid protection from local infection. This study shows that antigen recognition in MVA (modified vaccinia virus A…