Andreas Muth
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View article: Aligning perspectives: towards a standardized concept of “complexity” in thyroid surgery. An international web-based survey
Aligning perspectives: towards a standardized concept of “complexity” in thyroid surgery. An international web-based survey Open
Introduction Complication rates after thyroidectomy vary widely among centres. Various factors can affect the “complexity” of a case. However, an internationally agreed upon definition of what constitutes a “complex” case in thyroid surger…
View article: SUN-449 Randomized Trial of Adrenalectomy Versus Best Medical Practice for Mild Autonomous Cortisol Secretion
SUN-449 Randomized Trial of Adrenalectomy Versus Best Medical Practice for Mild Autonomous Cortisol Secretion Open
Disclosure: G. Ueland: None. O. Ragnarsson: None. A. Heie: None. A. Kjellbom: None. O. Lindgren: None. A. Muth: None. F. Palazzo: None. P.L. Poulsen: None. L. Rolighed: None. H. Thordarson: None. F. Wernig: None. A. Bergenfelz: None. Objec…
View article: Incidental thyroid nodules in a randomly selected cohort – the effects of screening
Incidental thyroid nodules in a randomly selected cohort – the effects of screening Open
Introduction Incidental thyroid nodules (ITN) are common findings, but they cause a dilemma for both clinicians and radiologists. Should all nodules be mentioned in the radiology report and is a follow-up ultrasound always necessary? Metho…
View article: Involvement of <scp>KEAP1</scp>/<scp>NRF2</scp> pathway in non‐<scp>BRAF</scp> mutated squamous cell carcinoma of the thyroid
Involvement of <span>KEAP1</span>/<span>NRF2</span> pathway in non‐<span>BRAF</span> mutated squamous cell carcinoma of the thyroid Open
Squamous cell carcinoma (SCC) of the thyroid is a rare tumor that is classified as an anaplastic thyroid cancer (ATC) due to its similar unresponsiveness to chemoradiotherapy and an outstandingly poor prognosis. Due to its rarity, current …
View article: Randomized trial studying metabolic outcomes and quality of life after adrenalectomy versus conservative management for mild autonomous cortisol secretion
Randomized trial studying metabolic outcomes and quality of life after adrenalectomy versus conservative management for mild autonomous cortisol secretion Open
Objective Evaluate the impact of adrenalectomy on metabolic parameters and quality of life (QoL) in patients with mild autonomous cortisol secretion (MACS). Method A multicenter prospective randomized clinical trial compared adrenalectomy …
View article: How ready are endocrine scientists to share retrospective clinical data for research: a perspective from the European Network for the Study of Adrenal Tumors
How ready are endocrine scientists to share retrospective clinical data for research: a perspective from the European Network for the Study of Adrenal Tumors Open
Objective Individual patients' data sharing requires interoperability, security, ethical, and legal compliance. The aim was to assess the landscape and sharing capacities between endocrine researchers. Design A standardized survey (SurveyM…
View article: Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours
Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours Open
Background: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs…
View article: Figure 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Experimental overview and primary tumor mutations. A, Consort diagram of the eligible patient cohort and study enrollment. The cohort consisted of all patients treated at the Deparment of Surgery, Sahlgrenska University Hospital, Gothenbur…
View article: Data from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Data from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
The majority of patients diagnosed with advanced gastrointestinal stromal tumors (GISTs) are successfully treated with a combination of surgery and tyrosine kinase inhibitors (TKIs). However, it remains challenging to monitor treatment eff…
View article: Figure 3 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 3 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Disease status in relation to ctDNA levels of tumor-specific and TKI resistance mutations. Black and gray bars indicate treatment duration. Disease status according to imaging. CR, complete response; PD, progressive disease; PR, partial re…
View article: Table 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Table 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Number of patients with tumor-specific mutations detected in cfDNA.
View article: Supplementary Tables from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Supplementary Tables from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Supplementary Table S1 shows detailed sample characteristics. Supplementary Table S2 shows sequences of synthetic spike-in DNA. Supplementary Table S3 shows assay sequences. Supplementary Table S4 shows details related to surgical treatmen…
View article: Table 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Table 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Patient demographics and tumor details.
View article: Supplementary Figures from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Supplementary Figures from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Supplementary Figure S1 shows assessment of quality controls when analyzing cfDNA. Supplementary Figure S2 shows a representative electropherogram of assay performance Supplementary Figure S3 shows a the amount of cfDNA in plasma for diffe…
View article: Table 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Table 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Number of patients with tumor-specific mutations detected in cfDNA.
View article: Figure 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Experimental overview and primary tumor mutations. A, Consort diagram of the eligible patient cohort and study enrollment. The cohort consisted of all patients treated at the Deparment of Surgery, Sahlgrenska University Hospital, Gothenbur…
View article: Figure 3 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 3 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Disease status in relation to ctDNA levels of tumor-specific and TKI resistance mutations. Black and gray bars indicate treatment duration. Disease status according to imaging. CR, complete response; PD, progressive disease; PR, partial re…
View article: Supplementary Tables from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Supplementary Tables from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Supplementary Table S1 shows detailed sample characteristics. Supplementary Table S2 shows sequences of synthetic spike-in DNA. Supplementary Table S3 shows assay sequences. Supplementary Table S4 shows details related to surgical treatmen…
View article: Supplementary Figures from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Supplementary Figures from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Supplementary Figure S1 shows assessment of quality controls when analyzing cfDNA. Supplementary Figure S2 shows a representative electropherogram of assay performance Supplementary Figure S3 shows a the amount of cfDNA in plasma for diffe…
View article: Figure 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
ctDNA characteristics in 32 patients diagnosed with GISTs. A, Detailed overview of tumor-specific ctDNA and clinical parameters. ctDNA status in relation to surgery is shown for each patient. Days at the bottom relates to surgical treatmen…
View article: Figure 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Figure 2 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
ctDNA characteristics in 32 patients diagnosed with GISTs. A, Detailed overview of tumor-specific ctDNA and clinical parameters. ctDNA status in relation to surgery is shown for each patient. Days at the bottom relates to surgical treatmen…
View article: Table 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Table 1 from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
Patient demographics and tumor details.
View article: Data from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors
Data from Monitoring Circulating Tumor DNA During Surgical Treatment in Patients with Gastrointestinal Stromal Tumors Open
The majority of patients diagnosed with advanced gastrointestinal stromal tumors (GISTs) are successfully treated with a combination of surgery and tyrosine kinase inhibitors (TKIs). However, it remains challenging to monitor treatment eff…
View article: Effects of Implementation of European Thyroid Imaging Reporting and Data System Risk Stratification in a Thyroid Cancer Program in Western Sweden: A Retrospective Cohort Study
Effects of Implementation of European Thyroid Imaging Reporting and Data System Risk Stratification in a Thyroid Cancer Program in Western Sweden: A Retrospective Cohort Study Open
Implementation of EU-TIRADS in routine management of thyroid nodules led to the selective use of FNAC; however, the clinical impact was limited. This study provides real-world data on the value and magnitude of diagnostic improvement by im…
View article: Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy
Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy Open
Background Gastrointestinal stromal tumour (GIST) is the most common intra-abdominal sarcoma. Risk classification systems, commonly the modified National Institutes of Health consensus criteria, identify tumour properties relating to patie…
View article: Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial
Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial Open
Background Techniques for autofluorescence have been introduced to visualize the parathyroid glands during surgery and to reduce hypoparathyroidism after thyroidectomy. Methods This parallel multicentre RCT investigated the use of Fluobeam…
View article: Therapeutic outcomes with surgical and medical management for primary aldosteronism: protocol for a systematic review and meta-analysis
Therapeutic outcomes with surgical and medical management for primary aldosteronism: protocol for a systematic review and meta-analysis Open
Introduction Treatment strategies for primary aldosteronism (PA) include unilateral adrenalectomy and medical treatment with mineralocorticoid receptor (MR) antagonists. Whether these two different treatment strategies are comparable in mi…