Explanipedia

Unconsciousness reshapes the oscillatory topography of the subthalamic nucleus: A comparative study Open

Laura Dubach, Alberto Averna, Laura Alva, Ines Debove, Elena Bernasconi , et al. · 2025

Unconsciousness reshapes the spectral and spatial topography of the STN in PD patients, hereby losing its predictive values for motor DBS-response. Dynamical changes of spectral features in space may inform future sleep-tailored DBS.

Literature Review on Lesion-Symptom Mapping and Deep Brain Stimulation for Poststroke Spasticity: Restoring a Dysfunctional Network? Open

Liliana María Favre, David Zhang, Claudio Pollo, Andreas Nowacki · 2025

Introduction: The present study aimed to define a structural network of stroke-induced and spasticity-related lesions and to relate this network to target sites and reported effects of deep brain stimulation (DBS) to treat poststroke spast…

Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain‐Sense Study Open

Aaron Colombo, Elena Bernasconi, Laura Alva, Mário Sousa, Ines Debove , et al. · 2025

Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings in Parkinson's disease (PD). Although various candidate biomarkers have …

Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy Open

Elena Bernasconi, Deborah Amstutz, Alberto Averna, Petra Fischer, Mário Sousa , et al. · 2025

Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life of Parkinson’s disease (PD) patients. Here we characterize the neurophysiological properties of the subth…

Biomarkers of neuropsychiatric symptoms in the Subthalamic Nucleus in Parkinson’s disease to inform closed-loop DBS Open

Elena Bernasconi, Deborah Amstutz, Alberto Averna, Petra Fischer, Mário Sousa , et al. · 2025

Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter? Open

S. Murcia Carretero, Katrin Petermann, Ines Debove, Deborah Amstutz, Mário Sousa , et al. · 2024

Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an accepted therapy for Parkinson's disease (PD) with disabling motor complications. For elderly patients with poorer cognition …

Should asleep deep brain stimulation in Parkinson’s disease be preferred over the awake approach? – Pros Open

Gerd Tinkhauser, Claudio Pollo, Ines Debove, Andreas Nowacki, Paul Krack · 2024

No abstract available.

Predictors of deep brain stimulation (DBS) responsein patients with obsessive compulsive disorder (OCD):a systematic review and meta-analysis Open

Santhosh G. Thavarajasingam, Amir P. Divanbeighi Zand, Daniele Ramsay, Sajeenth Vishnu K., Roma D. Thakker , et al. · 2024

Background: Obsessive-compulsive disorder (OCD) is a chronic and debilitating condition, often resistant to conventional treatments. Deep brain stimulation (DBS) emerges as a promising intervention, but its efficacy varies among patients, …

Designing next-generation subscalp devices for seizure monitoring: A systematic review and meta-analysis of established extracranial hardware Open

Sabry L. Barlatey, George Kouvas, A. Sobolewski, Andreas Nowacki, Claudio Pollo , et al. · 2024

Implantable brain recording and stimulation devices apply to a broad spectrum of conditions, such as epilepsy, movement disorders and depression. For long-term monitoring and neuromodulation in epilepsy patients, future extracranial subsca…

Triggered Seizures for Ictal SPECT Imaging: A Case Series and Feasibility Study Open

Sabry L. Barlatey, Camille G. Mignardot, Cecilia Friedrichs‐Maeder, Kaspar Schindler, Roland Wiest , et al. · 2024

Ictal SPECT is an informative seizure imaging technique to tailor epilepsy surgery. However, capturing the onset of unpredictable seizures is a medical and logistic challenge. Here, we sought to image planned seizures triggered by direct s…

Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson’s disease Open

Andreia D. Magalhães, Deborah Amstutz, Katrin Petermann, Ines Debove, Mário Sousa , et al. · 2024

Background Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson’s disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study w…

Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series Open

Simona Leserri, Alba Segura Amil, Andreas Nowacki, Ines Debove, Katrin Petermann , et al. · 2023

Programming of subthalamic nucleus deep brain stimulation with hyperdirect pathway and corticospinal tract‐guided parameter suggestions Open

Alba Segura Amil, Andreas Nowacki, Ines Debove, Katrin Petermann, Gerd Tinkhauser , et al. · 2023

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. Stimulation of the hyperdirect pathway (HDP) may mediate the beneficial effects, whereas stimulation of the corticosp…

Directional recordings of somatosensory evoked potentials from the sensory thalamus in chronic poststroke pain patients Open

Andreas Nowacki, David Zhang, Jonathan Wermelinger, Pablo Abel Alvarez Abut, Jan Rösner , et al. · 2023

Directional recordings of thalamic SEPs bear the potential to assist clinical decision-making in DBS for pain.

Spectral Topography of the Subthalamic Nucleus to Inform Next‐Generation Deep Brain Stimulation Open

Alberto Averna, Ines Debove, Andreas Nowacki, Katrin Peterman, Benoit Duchet , et al. · 2023

Background The landscape of neurophysiological symptoms and behavioral biomarkers in basal ganglia signals for movement disorders is expanding. The clinical translation of sensing‐based deep brain stimulation (DBS) also requires a thorough…

Deep Brain Stimulation: When to Test Directional? Open

Ines Debove, Katrin Petermann, Andreas Nowacki, T. A. Khoa Nguyen, Gerd Tinkhauser , et al. · 2023

Background Directional deep brain stimulation (DBS) allows for steering of the stimulation field, but extensive and time‐consuming testing of all segmented contacts is necessary to identify the possible benefit of steering. It is therefore…

How much space is needed for decompressive surgery in malignant middle cerebral artery infarction: Enabling single-stage surgery Open

Matteo Montalbetti, Sylvia Lörcher, Andreas Nowacki, Levin Häni, Werner J. Z’Graggen , et al. · 2023

The space provided by removal of the bone alone was sufficient to match the expansion of the injured brain after malignant MCA infarction in the vast majority of our patientsA subgaleal space-expanding flap with a minimal offset can provid…

Deep brain stimulation for Central Poststroke Pain Syndrome: International Multicenter Analysis Open

David Zhang, Andreas Nowacki, Khoa Nguyen Thuy Anh, Alba Segura Amil, Wilhelm Eisner , et al. · 2023

Optimal deep brain stimulation connectivity to treat Holmes tremor Open

Bassam Al‐Fatly, Inken Tödt, Martha Tischer, Joseph S. Neimat, Peter Hedera , et al. · 2023

Spectral topography of the human subthalamic nucleus in Parkinson’s disease Open

Alberto Averna, Ines Debove, Andreas Nowacki, Katrin Peterman, Benoit Duchet , et al. · 2023

Programming of subthalamic nucleus deep brain stimulation for Parkinson’s disease with sweet spot-guided parameter suggestions Open

Simon Nordenström, Katrin Petermann, Ines Debove, Andreas Nowacki, Paul Krack , et al. · 2022

Deep Brain Stimulation (DBS) is an effective treatment for advanced Parkinson’s disease. However, identifying stimulation parameters, such as contact and current amplitudes, is time-consuming based on trial and error. Directional leads add…

Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease Open

Ashesh Shah, T. A. Khoa Nguyen, Katrin Peterman, Saed Khawaldeh, Ines Debove , et al. · 2022

Probabilistic Mapping Reveals Optimal Stimulation Site in Essential Tremor Open

Andreas Nowacki, Sabry Barlatey, Bassam Al‐Fatly, Till A. Dembek, Maarten Bot , et al. · 2022

Objective The objective of this study was to obtain individual clinical and neuroimaging data of patients undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European centers to identify predictors of outcome…

Subthalamic and pallidal deep brain stimulation for Parkinson’s disease—meta-analysis of outcomes Open

M. Lenard Lachenmayer, Melina Mürset, Nicolas Antih, Ines Debove, Julia Muellner , et al. · 2021

Although deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the subthalamic nucleus (STN) has become an established treatment for Parkinson’s disease (PD), a recent meta-analysis of outcomes is lacking. To address this …

Stereotactic biopsies of brainstem lesions: which approach? Open

Amer Jaradat, Andreas Nowacki, Jens Fichtner, Janine-Ai Schlaeppi, Claudio Pollo · 2021

Individualized Brain Tissue Oxygen-Monitoring Probe Placement Helps to Guide Therapy and Optimizes Outcome in Neurocritical Care Open

Levin Häni, Mario D. Ropelato, Franca Wagner, Andreas Nowacki, Nicole Söll , et al. · 2020

Background/Objective In order to monitor tissue oxygenation in patients with acute neurological disorders, probes for measurement of brain tissue oxygen tension (ptO 2 ) are often placed non-specifically in a right frontal lobe location. T…

Stereotactic posterior midline approach under direct microscopic view for biopsy of medulla oblongata tumors: technical considerations Open

Janine-Ai Schlaeppi, Lukas Andereggen, Andreas Nowacki, Claudio Pollo · 2020

MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T Open

Kai D. Ludwig, Casey P. Johnson, Štefan Zbýň, Andreas Nowacki, Shelly Marette , et al. · 2020

Structure-function relationship of the posterior subthalamic area with directional deep brain stimulation for essential tremor Open

Jean-Philippe Lévy, T. A. Khoa Nguyen, L. Lachenmayer, Ines Debove, Gerd Tinkhauser , et al. · 2020

Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease Open

Saed Khawaldeh, Gerd Tinkhauser, Syed Ahmar Shah, Katrin Peterman, Ines Debove , et al. · 2019

Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson’s disease, a plausible mechanism linking the two phenomena has been lacking. He…

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