Andreas Patsalos
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View article: Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm
Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm Open
View article: Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture
Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture Open
Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenera…
View article: EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages
EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages Open
Alveolar macrophages (AMs) act as gatekeepers of the lung's immune responses, serving essential roles in recognizing and eliminating pathogens. The transcription factor (TF) early growth response 2 (EGR2) has been recently described as req…
View article: Editorial: Transcriptional regulation of macrophage function
Editorial: Transcriptional regulation of macrophage function Open
EDITORIAL article Front. Immunol., 02 November 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1321064
View article: Loss of adenosine A3 receptors accelerates skeletal muscle regeneration in mice following cardiotoxin-induced injury
Loss of adenosine A3 receptors accelerates skeletal muscle regeneration in mice following cardiotoxin-induced injury Open
View article: Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy Open
Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by absence of the protein dystrophin, which acts as a structural link between the basal lamina and contractile machinery to stabilize muscle membranes in response to mecha…
View article: Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation
Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation Open
Macrophage polarization is a process whereby macrophages develop a specific phenotype and functional response to different pathophysiological stimuli and tissue environments. In general, two main macrophage phenotypes have been identified:…
View article: Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes Open
BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesi…
View article: A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15 Open
Muscle regeneration is the result of the concerted action of multiple cell types driven by the temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages. Pro-inflammatory macrophages transition into a phenotype…
View article: Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis Open
Aim: The aim of our study was to explore the pathophysiologic role of oxidation of hemoglobin (Hb) to ferrylHb in human atherosclerosis. Results: We observed a severe oxidation of Hb to ferrylHb in complicated a…
View article: Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle
Myeloid cell diversification during regenerative inflammation: Lessons from skeletal muscle Open
View article: Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression
Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression Open
Hemorrhage and hemolysis with subsequent heme release are implicated in many pathologies. Endothelial cells (ECs) encounter large amount of free heme after hemolysis and are at risk of damage from exogenous heme. Here we show that hemorrha…
View article: Myeloid ALX/FPR2 regulates vascularization following tissue injury
Myeloid ALX/FPR2 regulates vascularization following tissue injury Open
Ischemic injury initiates a sterile inflammatory response that ultimately participates in the repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery during ischemia, in part because they produce growth fac…
View article: Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis
Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis Open
In sepsis, platelets may become activated via toll-like receptors (TLRs), causing microvascular thrombosis. Megakaryocytes (MKs) also express these receptors; thus, severe infection may modulate thrombopoiesis. To explore the relevance of …
View article: Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle
Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle Open
Duchenne muscular dystrophy (DMD) is a devastating genetic muscle disease resulting in progressive muscle degeneration and wasting. Glucocorticoids, specifically prednisone/prednisolone and deflazacort, are commonly used by DMD patients. E…
View article: The BACH1–HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration
The BACH1–HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration Open
The infiltration and subsequent in situ subtype specification of monocytes to effector/inflammatory and repair macrophages is indispensable for tissue repair upon acute sterile injury. However, the chromatin-level mediators and regulatory …
View article: Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration
Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration Open
View article: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration Open
Muscle damage elicits a sterile immune response that facilitates complete regeneration. Here, we used mass spectrometry-based lipidomics to map the mediator lipidome during the transition from inflammation to resolution and regeneration in…
View article: The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory
The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory Open
View article: Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons Open
Aging contributes to cellular stress and neurodegeneration. Our understanding is limited regarding the tissue-restricted mechanisms providing protection in postmitotic cells throughout life. Here, we show that spinal cord motoneurons exhib…
View article: In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury
In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury Open
Tissue regeneration is a highly coordinated process with sequential events including immune cell infiltration, clearance of damaged tissues, and immune‐supported regrowth of the tissue. Aging has a well‐documented negative impact on this p…
View article: <i>In situ</i> macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury
<i>In situ</i> macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury Open
Key points The in situ phenotypic switch of macrophages is delayed in acute injury following irradiation. The combination of bone marrow transplantation and local muscle radiation protection allows for the identification of a myeloid cell …
View article: Great need for changes in higher education in Greece
Great need for changes in higher education in Greece Open
View article: Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration
Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration Open