Andreas Pohlmann
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View article: Cardiac Phase-Resolved T2* Magnetic Resonance Imaging Reveals Differences Between Normal Hearts and a Humanized Mouse Model of Hypertrophic Cardiomyopathy
Cardiac Phase-Resolved T2* Magnetic Resonance Imaging Reveals Differences Between Normal Hearts and a Humanized Mouse Model of Hypertrophic Cardiomyopathy Open
Background/Objectives: While T2* mapping effectively assesses cerebral blood oxygenation, its utility for capturing cardiac phase-dependent myocardial changes in hypertrophic cardiomyopathy (HCM) is underexplored. This study investigates T…
View article: Towards MRI axon radius mapping in clinical settings: insights from MRI-scale histology and experimental validation
Towards MRI axon radius mapping in clinical settings: insights from MRI-scale histology and experimental validation Open
The MRI-visible axon radius is a potential clinical biomarker for, e.g., neurological disorders. However, its clinical potential remains untapped, as in-vivo MRI-based estimation lacks validation in humans and currently requires specialize…
View article: Short association fibres form topographic sheets in the human V1–V2 processing stream
Short association fibres form topographic sheets in the human V1–V2 processing stream Open
Despite the importance of short association fibres (SAF) for human brain function, their structures remain understudied. It is not known how SAF are organised across the brain, and how consistent their geometries and locations are across i…
View article: MRI-scale histology validates spatial sensitivity of in-vivo MRI-based axon radius estimation
MRI-scale histology validates spatial sensitivity of in-vivo MRI-based axon radius estimation Open
The axon radius holds promise as a clinical MRI biomarker for neurological disorders. However, in-vivo MRI estimation appears infeasible on clinical scanners and lacks experimental validation. Crucially, existing histology is only sparsely…
View article: Arterial Spin Labeling and T2* Mapping Detect Early Changes in Hypertrophic Cardiomyopathy
Arterial Spin Labeling and T2* Mapping Detect Early Changes in Hypertrophic Cardiomyopathy Open
View article: Fiber-orientation independent component of R2* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm
Fiber-orientation independent component of R2* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm Open
The effective transverse relaxation rate (R 2 *) is sensitive to the microstructure of the human brain like the g-ratio which characterises the relative myelination of axons. However, the fibre-orientation dependence of R 2 * degrades its …
View article: Ku et al_supplemental_methods from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas
Ku et al_supplemental_methods from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas Open
Supplemental Methods
View article: Data from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas
Data from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas Open
Glioma regression requires the recruitment of potent antitumor immune cells into the tumor microenvironment. Dendritic cells (DC) play a role in immune responses to these tumors. The fact that DC vaccines do not effectively combat high-gra…
View article: Ku et al_supplemental_methods from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas
Ku et al_supplemental_methods from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas Open
Supplemental Methods
View article: Data from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas
Data from ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas Open
Glioma regression requires the recruitment of potent antitumor immune cells into the tumor microenvironment. Dendritic cells (DC) play a role in immune responses to these tumors. The fact that DC vaccines do not effectively combat high-gra…
View article: Deciphering the fibre-orientation independent component of R<sub>2</sub>* (R<sub>2,iso</sub>*) in the human brain with a single multi-echo gradient-recalled-echo measurement under varying microstructural conditions
Deciphering the fibre-orientation independent component of R<sub>2</sub>* (R<sub>2,iso</sub>*) in the human brain with a single multi-echo gradient-recalled-echo measurement under varying microstructural conditions Open
The effective transverse relaxation rate (R 2 *) is sensitive to the microstructure of the human brain, e.g. the g-ratio characterising the relative myelination of axons. However, R 2 * depends on the orientation of the fibres relative to …
View article: B<sub>1</sub>inhomogeneity correction of RARE MRI at low SNR: Quantitative in vivo<sup>19</sup>F MRI of mouse neuroinflammation with a cryogenically‐cooled transceive surface radiofrequency probe
B<sub>1</sub>inhomogeneity correction of RARE MRI at low SNR: Quantitative in vivo<sup>19</sup>F MRI of mouse neuroinflammation with a cryogenically‐cooled transceive surface radiofrequency probe Open
Purpose Low SNR in fluorine‐19 ( 19 F) MRI benefits from cryogenically‐cooled transceive surface RF probes (CRPs), but strong B 1 inhomogeneities hinder quantification. Rapid acquisition with refocused echoes (RARE) is an SNR‐efficient met…
View article: Reliable kidney size determination by magnetic resonance imaging in pathophysiological settings
Reliable kidney size determination by magnetic resonance imaging in pathophysiological settings Open
Aim Kidney diseases constitute a major health challenge, which requires noninvasive imaging to complement conventional approaches to diagnosis and monitoring. Several renal pathologies are associated with changes in kidney size, offering a…
View article: Continuous diffusion spectrum computation for diffusion-weighted magnetic resonance imaging of the kidney tubule system
Continuous diffusion spectrum computation for diffusion-weighted magnetic resonance imaging of the kidney tubule system Open
This work demonstrates the feasibility of NNLS modelling for DWI of the kidney tubule system and shows its potential for examining diffusion compartments associated with renal pathophysiology including ITV fraction and different degrees of…
View article: Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy
Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy Open
View article: Denoising for Improved Parametric MRI of the Kidney: Protocol for Nonlocal Means Filtering
Denoising for Improved Parametric MRI of the Kidney: Protocol for Nonlocal Means Filtering Open
View article: Preclinical MRI of the Kidney
Preclinical MRI of the Kidney Open
This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridg…
View article: Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies
Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies Open
Renal MRI holds incredible promise for making a quantum leap in improving diagnosis and care of patients with a multitude of diseases, by moving beyond the limitations and restrictions of current routine clinical practice. Clinical and pre…
View article: Experimental Protocol for MRI Mapping of the Blood Oxygenation-Sensitive Parameters T2* and T2 in the Kidney
Experimental Protocol for MRI Mapping of the Blood Oxygenation-Sensitive Parameters T2* and T2 in the Kidney Open
Renal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins, and has also been suggested to play a role in the development of chronic kidney disease. Here we describe a step-by-step experim…
View article: Hardware Considerations for Preclinical Magnetic Resonance of the Kidney
Hardware Considerations for Preclinical Magnetic Resonance of the Kidney Open
View article: Functional Imaging Using Fluorine (19F) MR Methods: Basic Concepts
Functional Imaging Using Fluorine (19F) MR Methods: Basic Concepts Open
View article: Monitoring Renal Hemodynamics and Oxygenation by Invasive Probes: Experimental Protocol
Monitoring Renal Hemodynamics and Oxygenation by Invasive Probes: Experimental Protocol Open
View article: <i>In vivo</i> detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy
<i>In vivo</i> detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy Open
Background: Magnetic resonance imaging (MRI) is indispensable for diagnosing neurological conditions such as multiple sclerosis (MS). MRI also supports decisions regarding the choice of disease-modifying drugs (DMDs). Determining
View article: Fluorine (19F) MRI for Assessing Inflammatory Cells in the Kidney: Experimental Protocol
Fluorine (19F) MRI for Assessing Inflammatory Cells in the Kidney: Experimental Protocol Open
Inflammation is one underlying contributing factor in the pathology of acute and chronic kidney disorders. Phagocytes such as monocytes, neutrophils and dendritic cells are considered to play a deleterious role in the progression of kidney…
View article: Subsegmentation of the Kidney in Experimental MR Images Using Morphology-Based Regions-of-Interest or Multiple-Layer Concentric Objects
Subsegmentation of the Kidney in Experimental MR Images Using Morphology-Based Regions-of-Interest or Multiple-Layer Concentric Objects Open
View article: Renal MRI Diffusion: Experimental Protocol
Renal MRI Diffusion: Experimental Protocol Open
Renal diffusion-weighted imaging (DWI) can be used to obtain information on the microstructure of kidney tissue, and has the potential to provide MR-biomarkers for functional renal imaging. Here we describe in a step-by-step experimental p…
View article: Essential Practical Steps for MRI of the Kidney in Experimental Research
Essential Practical Steps for MRI of the Kidney in Experimental Research Open
View article: Analysis Protocols for MRI Mapping of the Blood Oxygenation–Sensitive Parameters T2* and T2 in the Kidney
Analysis Protocols for MRI Mapping of the Blood Oxygenation–Sensitive Parameters T2* and T2 in the Kidney Open
Renal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins and has also been suggested to play a role in the development of chronic kidney disease. Here we describe step-by-step data analy…
View article: Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis
Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis Open
The brain ventricles are part of the fluid compartments bridging the CNS with the periphery. Using MRI, we previously observed a pronounced increase in ventricle volume (VV) in the experimental autoimmune encephalomyelitis (EAE) model of m…
View article: B<sub>1</sub> inhomogeneity correction of RARE MRI with transceive surface radiofrequency probes
B<sub>1</sub> inhomogeneity correction of RARE MRI with transceive surface radiofrequency probes Open
Purpose The use of surface radiofrequency (RF) coils is common practice to boost sensitivity in (pre)clinical MRI. The number of transceive surface RF coils is rapidly growing due to the surge in cryogenically cooled RF technology and ultr…