Andreas Prokop
YOU?
Author Swipe
View article: Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration
Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration Open
Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e., oxidative stress. However, apart from ATP production, mitochondria have many other functions the …
View article: Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology
Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology Open
In neurodegeneration, axons tend to be prime lesion sites. Axons are the slender, up-to-meter-long processes of nerve cells that essentially wire nervous systems. These delicate structures must survive for an organism’s lifetime. Their lon…
View article: Toward more sustainable research: reducing the environmental impact when working with <i>Drosophila</i>
Toward more sustainable research: reducing the environmental impact when working with <i>Drosophila</i> Open
The ever-increasing amounts of plastic waste and greenhouse gas emissions worldwide threaten our environment. Biomedical laboratories across the world generate serious amounts of plastic waste often disposed of via high-emission strategies…
View article: Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration
Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration Open
Mitochondrial dysfunction is an important cause for neurodegeneration, often associated with dyshomeostasis of reactive oxygen species, i.e. oxidative stress. However, apart from ATP production, mitochondria have many other functions the a…
View article: Targeted plasma proteomics uncover novel proteins associated with <i>KIF5A</i> -linked SPG10 and ALS spectrum disorders
Targeted plasma proteomics uncover novel proteins associated with <i>KIF5A</i> -linked SPG10 and ALS spectrum disorders Open
KIF5A (Kinesin family member 5A) is a motor protein that functions as a key component of the axonal transport machinery. Variants in KIF5A are linked to several neurodegenerative diseases, mainly spastic paraplegia type 10 (SPG10), Charcot…
View article: The Internal Otic Region of Oromerycids (Artiodactyla, Oromerycidae), Early Camelids (Artiodactyla, Camelidae), and the Vicuña (Artiodactyla, Camelidae), Including Notes on Intraspecific and Subadult Ontogenetic Variation
The Internal Otic Region of Oromerycids (Artiodactyla, Oromerycidae), Early Camelids (Artiodactyla, Camelidae), and the Vicuña (Artiodactyla, Camelidae), Including Notes on Intraspecific and Subadult Ontogenetic Variation Open
Synopsis The taxonomic composition of the suborder Tylopoda is an ongoing debate. Recently, the internal otic region (petrosal and bony labyrinth) has been intensively studied as a source of additional morphological data, but the morpholog…
View article: Different mechanisms link gain and loss of kinesin functions to axonal degeneration
Different mechanisms link gain and loss of kinesin functions to axonal degeneration Open
Axons are the slender, often meter-long projections of neurons that form the biological cables wiring our bodies. Most of these delicate structures must survive for an organism’s lifetime, meaning up to a century in humans. Long-term maint…
View article: Understanding the underlying causes of degenerative neural diseases
Understanding the underlying causes of degenerative neural diseases Open
Degenerative neural diseases (DNDs), such as dementia, Parkinson’s disease, motor neuron disease and multiple sclerosis, are becoming more prevalent in our ageing society. Here we explain why different DND classes display characteristic di…
View article: Flow in filopodia: re-organization and the representation of biological entities as computational objects
Flow in filopodia: re-organization and the representation of biological entities as computational objects Open
Actin is the most abundant protein in eukaryotic cells. They form filamentous polymers that are organized in different ways within the cell to perform various functions. For instance, prominent parallel bundles of F-actins mediate the form…
View article: The Shot CH1 domain recognises a distinct form of F-actin during <i>Drosophila</i> oocyte determination
The Shot CH1 domain recognises a distinct form of F-actin during <i>Drosophila</i> oocyte determination Open
In Drosophila, only one cell in a multicellular female germline cyst is specified as an oocyte and a similar process occurs in mammals. The symmetry-breaking cue for oocyte selection is provided by the fusome, a tubular structure connectin…
View article: The role of Ataxin‐2 in Drosophila models of C9orf72‐related FTD expressing dipeptide‐repeats of a physiologically relevant length
The role of Ataxin‐2 in Drosophila models of C9orf72‐related FTD expressing dipeptide‐repeats of a physiologically relevant length Open
Background Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two devastating, incurable, early‐onset neurodegenerative diseases, which share a clinicopathological spectrum of disease; linked by a hexanucleotide (GGG…
View article: How neurons maintain their axons long-term: an integrated view of axon biology and pathology
How neurons maintain their axons long-term: an integrated view of axon biology and pathology Open
Axons are processes of neurons, up to a metre long, that form the essential biological cables wiring nervous systems. They must survive, often far away from their cell bodies and up to a century in humans. This requires self-sufficient cel…
View article: The Shot CH1 domain recognises a distinct form of F-actin during<i>Drosophila</i>oocyte determination
The Shot CH1 domain recognises a distinct form of F-actin during<i>Drosophila</i>oocyte determination Open
As in mammals, only one cell in a Drosophila multicellular female germline cyst is specified as an oocyte. The symmetry-breaking cue for oocyte selection is provided by the fusome, a tubular structure connecting all cells in the cyst. The …
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: Re‐evaluating the actin‐dependence of spectraplakin functions during axon growth and maintenance
Re‐evaluating the actin‐dependence of spectraplakin functions during axon growth and maintenance Open
Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require loose microtubule bundles that extend through their entire length. Understandi…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…
View article: Supervision and guidance during the process of essay writing in the life sciences
Supervision and guidance during the process of essay writing in the life sciences Open
Many years of supervision in essay writing have led to a strategy that has worked for many students and is based on a clearly structured schedule of events. It is highly effective, saves the student's and supervisor's time, and it provides…
View article: Supervision and guidance during the process of essay writing in the life sciences
Supervision and guidance during the process of essay writing in the life sciences Open
Many years of supervision in essay writing have led to a strategy that has worked for many students and is based on a clearly structured schedule of events. It is highly effective, saves the student's and supervisor's time, and it provides…
View article: 2nd year Drosophila Developmental Genetics practical
2nd year Drosophila Developmental Genetics practical Open
This is the teaching material for the Drosophila module of the Developmental Genetics RSM (research skills module) held at the Faculty of Biology, Medicine and Health of The University of Manchester each year. This practical course runs ov…