Andreas Rieth
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View article: Right Atrial Contraction Strain Is Associated With Clinically Significant Cellular Rejection in Patients After Heart Transplantation
Right Atrial Contraction Strain Is Associated With Clinically Significant Cellular Rejection in Patients After Heart Transplantation Open
Strain echocardiography (SE) may be used for surveillance in patients after heart transplantation (HTx); however, data on atrial strain are lacking. We aimed to compare the significance of ventricular and atrial strain with respect to an a…
View article: Abnormal Left Atrial Strain by CMR Is Associated With Left Heart Disease in Patients With Pulmonary Hypertension
Abnormal Left Atrial Strain by CMR Is Associated With Left Heart Disease in Patients With Pulmonary Hypertension Open
BACKGROUND: Pulmonary hypertension (PH) is classified as precapillary, isolated postcapillary pulmonary hypertension (IpcPH), combined postcapillary and precapillary (CpcPH), or exercise PH. IpcPH associated with left heart disease can lea…
View article: Serial cardiac magnetic resonance imaging to assess myocardial inflammation in PET-positive cardiac sarcoidosis under immunomodulatory therapy: a retrospective observational study
Serial cardiac magnetic resonance imaging to assess myocardial inflammation in PET-positive cardiac sarcoidosis under immunomodulatory therapy: a retrospective observational study Open
Objective To evaluate changes in cardiac magnetic resonance (CMR) tissue characteristics in patients with active cardiac sarcoidosis (CS) confirmed by positron emission tomography (PET)-CT undergoing immunomodulatory therapy (IMT), and to …
View article: Rationale and design of the randomized ‘early ventricular assist device’—Trial (VAD‐DZHK3)
Rationale and design of the randomized ‘early ventricular assist device’—Trial (VAD‐DZHK3) Open
Aims Bridge to transplantation (BTT) with durable, continuous‐flow left ventricular assist devices (LVAD) of patients is a well‐established treatment concept in patients awaiting heart transplantation (HTx). However, the role of elective L…
View article: <scp>DIGitoxin</scp> to Improve <scp>ouTcomes</scp> in patients with advanced chronic Heart Failure (<scp>DIGIT</scp>‐<scp>HF</scp>): Baseline characteristics compared to recent randomized controlled heart failure trials
<span>DIGitoxin</span> to Improve <span>ouTcomes</span> in patients with advanced chronic Heart Failure (<span>DIGIT</span>‐<span>HF</span>): Baseline characteristics compared to recent randomized controlled heart failure trials Open
Aims This report presents the baseline characteristics of patients enrolled in the DIGIT‐HF trial and compares them with participants from recent trials with improved outcomes in patients with heart failure (HF) and a reduced ejection frac…
View article: The <scp>DIGIT</scp>‐<scp>HF</scp> trial: Key amendments of study design
The <span>DIGIT</span>‐<span>HF</span> trial: Key amendments of study design Open
View article: Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials
Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials Open
View article: Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction
Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction Open
Importance Although the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonst…
View article: t2-mapping Is a Valuable Tool in Monitoring Inflammation in Cardiac Sarcoidosis Under Immunosuppressive Therapy
t2-mapping Is a Valuable Tool in Monitoring Inflammation in Cardiac Sarcoidosis Under Immunosuppressive Therapy Open
View article: Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2)
Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2) Open
Zusammenfassung Die pulmonale Hypertonie in Verbindung mit Linksherzerkrankungen (PH-LHD) bildet in der klinischen Klassifikation die Gruppe 2 der pulmonalen Hypertonie ab. Hämodynamisch zählt zu dieser Gruppe die isoliert postkapilläre pu…
View article: Echocardiographic pressure–strain loop‐derived stroke work of the right ventricle: validation against the gold standard
Echocardiographic pressure–strain loop‐derived stroke work of the right ventricle: validation against the gold standard Open
Aims Commercially available integrated software for echocardiographic measurement of stroke work (SW) is increasingly used for the right ventricle, despite a lack of validation. We sought to assess the validity of this method [echo‐based m…
View article: Native T2 Predicts Myocardial Inflammation Irrespective of a Patient’s Volume Status
Native T2 Predicts Myocardial Inflammation Irrespective of a Patient’s Volume Status Open
Myocardial inflammation and edema are major pathological features in myocarditis. Myocardial tissue water content and myocardial edema can be quantified via T2 mapping. Thus, cardiac magnetic resonance (CMR) is the noninvasive gold standar…
View article: Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial
Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial Open
Background The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF tri…
View article: Regional extracellular volume within late gadolinium enhancement-positive myocardium to differentiate cardiac sarcoidosis from myocarditis of other etiology: a cardiovascular magnetic resonance study
Regional extracellular volume within late gadolinium enhancement-positive myocardium to differentiate cardiac sarcoidosis from myocarditis of other etiology: a cardiovascular magnetic resonance study Open
This is the first study to show that the calculation of regional ECV within LGE-positive regions may help to differentiate CS from myocarditis. Further studies are warranted to corroborate these findings.
View article: Exercise MR-proANP unmasks latent right heart failure in CTEPH
Exercise MR-proANP unmasks latent right heart failure in CTEPH Open
Background Chronic right heart failure is the major determinant of outcome in chronic thromboembolic pulmonary hypertension (CTEPH). Thus, its early detection is crucial for optimal patient management. Hemodynamic assessment with invasive …
View article: Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension
Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension Open
Graphical Abstract
View article: CILP1 as a biomarker for right ventricular dysfunction in patients with ischemic cardiomyopathy
CILP1 as a biomarker for right ventricular dysfunction in patients with ischemic cardiomyopathy Open
The aim of this study was to evaluate the cartilage intermediate layer protein 1 (CILP1) as a biomarker of right ventricular dysfunction in patients with ischemic cardiomyopathy (ICM). CILP1 plasma concentrations were measured in 98 patien…
View article: Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy
Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy Open
The main aim of this study was to assess the prognostic utility of TAPSE/PASP as an echocardiographic parameter of maladaptive RV remodeling in cardiomyopathy patients using cardiac magnetic resonance (CMR) imaging. Furthermore, we sought …
View article: Predictive value of overt and non-overt volume overload in patients with high- or low-gradient aortic stenosis undergoing transcatheter aortic valve implantation
Predictive value of overt and non-overt volume overload in patients with high- or low-gradient aortic stenosis undergoing transcatheter aortic valve implantation Open
PVS and PCD represent two independent parameters of volume overload with unfavorable prognostic significance. Pre-interventional PVS does not appear to be suitable for predicting clinical outcomes in high-risk patients undergoing TAVI.
View article: Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair
Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair Open
Background: Percutaneous mitral valve repair (PMVR) in high-risk patients is currently controversial, especially in those with secondary mitral regurgitation (MR). Exercise pulmonary hemodynamics may help to unmask cardiac dysfunction as w…
View article: Identifying Heart Failure in ECG Data With Artificial Intelligence—A Meta-Analysis
Identifying Heart Failure in ECG Data With Artificial Intelligence—A Meta-Analysis Open
Introduction: Electrocardiography (ECG) is a quick and easily accessible method for diagnosis and screening of cardiovascular diseases including heart failure (HF). Artificial intelligence (AI) can be used for semi-automated ECG analysis. …
View article: Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology
Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology Open
Our data support the fact that Hereditary Transthyretin-Related Amyloidosis is underdiagnosed in polyneuropathy and cardiomyopathy patients. Routine implementation of genetic testing is recommended in patients with unexplained polyneuropat…
View article: Herzinsuffizienzprotektion bei Patienten mit Diabetes mellitus Typ 2 durch SGLT2-Inhibitoren – Evidenzlage und mögliche Mechanismen
Herzinsuffizienzprotektion bei Patienten mit Diabetes mellitus Typ 2 durch SGLT2-Inhibitoren – Evidenzlage und mögliche Mechanismen Open
View article: COVID-19 among heart transplant recipients in Germany: a multicenter survey
COVID-19 among heart transplant recipients in Germany: a multicenter survey Open
View article: Exercise right heart catheterization before and after balloon pulmonary angioplasty in inoperable patients with chronic thromboembolic pulmonary hypertension
Exercise right heart catheterization before and after balloon pulmonary angioplasty in inoperable patients with chronic thromboembolic pulmonary hypertension Open
Background Balloon pulmonary angioplasty is an evolving, interventional treatment option for inoperable patients with chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary hypertension at rest as well as exercise capacity is con…
View article: Association of galectin-3 with changes in left ventricular function in recent-onset dilated cardiomyopathy
Association of galectin-3 with changes in left ventricular function in recent-onset dilated cardiomyopathy Open
Background: The course of newly diagnosed dilated cardiomyopathy (DCM) varies from persistent reduction of left ventricular ejection fraction (LVEF) to recovery or even worsening. The aim of the present study was to examine the prog…
View article: Acute response to rapid iloprost inhalation using the Breelib™ nebulizer in pulmonary arterial hypertension: the Breelib™ acute study
Acute response to rapid iloprost inhalation using the Breelib™ nebulizer in pulmonary arterial hypertension: the Breelib™ acute study Open
The Breelib™ nebulizer was designed to reduce iloprost inhalation times for patients with pulmonary arterial hypertension (PAH). In 30 patients with PAH, rapid inhalation of iloprost 2.5 µg using Breelib™ caused significant improvements in…
View article: Rationale and design of the DIGIT‐HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double‐blind, placebo‐controlled study
Rationale and design of the DIGIT‐HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double‐blind, placebo‐controlled study Open
Aims Despite recent advances in the treatment of chronic heart failure (HF), mortality and hospitalizations still remain high. Additional therapies to improve mortality and morbidity are urgently needed. The efficacy of cardiac glycosides …
View article: Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension Open
Non-invasive biomarker measurement provides valuable evidence for the decreasing impairment of myocardial function and structure during BPA therapy. Changes in hs-cTNT levels are suggestive for a reduction in ongoing myocardial damage.
View article: Intravenous sildenafil acutely improves hemodynamic response to exercise in patients with connective tissue disease
Intravenous sildenafil acutely improves hemodynamic response to exercise in patients with connective tissue disease Open
BackgroundHemodynamic assessment during exercise may unmask an impaired functional reserve of the right ventricle and the pulmonary vasculature in patients with connective tissue disease. We assessed the effect of intravenous sildenafil on…