Martin Ritter
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View article: Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells
Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells Open
Cell‐free enzymatic assays are highly useful tools in early compound profiling due to their robustness and scalability. However, their inadequacy to reflect the complexity of target engagement in a cellular environment may lead to a signif…
View article: Identification of (<i>R</i>)-[<sup>18</sup>F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development
Identification of (<i>R</i>)-[<sup>18</sup>F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development Open
This study aimed to evaluate (R)-[18F]YH134 as a novel PET tracer for imaging monoacylglycerol lipase (MAGL). Considering the ubiquitous expression of MAGL throughout the whole body, the impact of various MAGL inhibitors on (R)-[18F]YH134 …
View article: Predictors of Atrial Fibrillation in Patients with Embolic Stroke of Unknown Etiology and Implantable Loop Recorders—Further Insights of the TRACK AF Study on the Role of ECG and Echocardiography
Predictors of Atrial Fibrillation in Patients with Embolic Stroke of Unknown Etiology and Implantable Loop Recorders—Further Insights of the TRACK AF Study on the Role of ECG and Echocardiography Open
Aims—Electrocardiography (ECG) and echocardiographic left atrial (LA) parameters may be helpful to assess the risk of atrial fibrillation (AF) in embolic stroke of unknown etiology (ESUS) and could therefore guide intensity of ECG monitori…
View article: EP25.12: Role of ductus venosus Doppler for the prediction of perinatal outcome in term pregnancies with gestational diabetes mellitus
EP25.12: Role of ductus venosus Doppler for the prediction of perinatal outcome in term pregnancies with gestational diabetes mellitus Open
Ductus venosus (DV) Doppler reflects fetal cardiac function especially right atrial pressure. Gestational diabetes mellitus (GDM) is assumed to impair cardiac function due to fetal hyperglycemia, academia and myocardial hypertrophy. The pu…
View article: Photon echoes using atomic frequency combs in Pr:YSO — experiment and semiclassical theory
Photon echoes using atomic frequency combs in Pr:YSO — experiment and semiclassical theory Open
Photon echoes in rare-earth-doped crystals are studied to understand the challenges of making broadband quantum memories using the atomic frequency comb (AFC) protocol in systems with hyperfine structure. The hyperfine structure of Pr 3+ p…
View article: Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial
Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial Open
Background: Patients with symptomatic internal carotid artery (ICA) stenosis are at high risk of recurrent ischemic stroke and require early interventional treatment and antiplatelet therapy. Increased bleeding rates might counterbalance t…
View article: Photon echoes using atomic frequency combs in Pr:YSO -- experiment and semiclassical theory
Photon echoes using atomic frequency combs in Pr:YSO -- experiment and semiclassical theory Open
Photon echoes in rare-earth-doped crystals are studied to understand the challenges of making broadband quantum memories using the atomic frequency comb (AFC) protocol in systems with hyperfine structure. The hyperfine structure of Pr^{3+}…
View article: DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome
DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome Open
The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these techniques act via a reduction of DDR1 protein, while we prove the therapeutic po…
View article: Development of a radioactive holmium-166 skin patch to treat skin cancer
Development of a radioactive holmium-166 skin patch to treat skin cancer Open
Skin cancer is the most common form of cancer affecting over 3 million people per year in the US alone. The two most common forms of cancer, basal and squamous cell carcinoma, are easily removable if detected early and properly treated. Th…
View article: The Association of Lesion Location and Sleep Related Breathing Disorder in Patients with Acute Ischemic Stroke
The Association of Lesion Location and Sleep Related Breathing Disorder in Patients with Acute Ischemic Stroke Open
We found no association of lesion location and SRBD in stroke patients, whereas established risk factors for SRBD, known from general population, were significantly associated with SRBD. Given the high prevalence of SRBD in stroke patients…