Andreas Schertel
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View article: Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues
Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues Open
View article: Application of cryo-FIB-SEM for investigating ultrastructure in guard cells of higher plants
Application of cryo-FIB-SEM for investigating ultrastructure in guard cells of higher plants Open
Stomata are vital for CO2 and water vapor exchange, with guard cells' aperture and ultrastructure highly responsive to environmental cues. However, traditional methods for studying guard cell ultrastructure, which rely on chemic…
View article: Application of cryo-FIB-SEM for investigating organelle ultrastructure in guard cells of higher plants
Application of cryo-FIB-SEM for investigating organelle ultrastructure in guard cells of higher plants Open
Stomata are vital for CO2 and water vapor exchange, with guard cells’ aperture and ultrastructure highly responsive to environmental cues. However, traditional methods for studying guard cell ultrastructure, which rely on chemical fixation…
View article: CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain
CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain Open
A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures 1 . In Alzheimer’s disease, this is characterized by the deposition of β-amyloid and tau with…
View article: CryoEM movies of human tau amyloid fibrils extracted from an AD patient brain (in association with in situ cryoET)
CryoEM movies of human tau amyloid fibrils extracted from an AD patient brain (in association with in situ cryoET) Open
View article: <i>In situ</i>cryo-electron tomography of β-amyloid and tau in post-mortem Alzheimer’s disease brain
<i>In situ</i>cryo-electron tomography of β-amyloid and tau in post-mortem Alzheimer’s disease brain Open
A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures. In Alzheimer’s disease (AD) this is characterised by the deposition of amyloid-β (Aβ) and ta…
View article: Internal microstructure of spray dried particles affects viral vector activity in dry vaccines
Internal microstructure of spray dried particles affects viral vector activity in dry vaccines Open
View article: Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans
Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans Open
View article: TCF12 controls oligodendroglial cell proliferation and regulates signaling pathways conserved in gliomas
TCF12 controls oligodendroglial cell proliferation and regulates signaling pathways conserved in gliomas Open
Diffuse gliomas are primary brain tumors originating from the transformation of glial cells. In particular, oligodendrocyte precursor cells constitute the major tumor-amplifying population in the gliomagenic process. We previously identifi…
View article: Biomineralization pathways in calcifying dinoflagellates: uptake, storage in MgCaP-rich bodies and formation of the shell
Biomineralization pathways in calcifying dinoflagellates: uptake, storage in MgCaP-rich bodies and formation of the shell Open
View article: Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells
Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells Open
View article: Serial cryoFIB/SEM reveals profound cytoarchitectural disruptions caused by a pathogenic mutation in Leigh syndrome patient cells
Serial cryoFIB/SEM reveals profound cytoarchitectural disruptions caused by a pathogenic mutation in Leigh syndrome patient cells Open
The advancement of serial cryo-FIB/SEM offers a new opportunity to study large volumes of near-native, fully hydrated frozen cells and tissues at voxel sizes of 10 nm and below. We explored this capability for pathologic characterization o…
View article: A three-dimensional reconstruction of coal microstructure using the Cryo-FIB-SEM technique
A three-dimensional reconstruction of coal microstructure using the Cryo-FIB-SEM technique Open
Two basic homogeneous lithotypes, defined as elementary coal layers, within the seam of lignite can be distinguished: xylitic and detritic coal. As each of them exhibits various features, including structure, mechanical, technological prop…
View article: Cryo-FIB-SEM as a promising tool for localizing proteins in 3D
Cryo-FIB-SEM as a promising tool for localizing proteins in 3D Open
View article: Fully automated, sequential focused ion beam milling for cryo-electron tomography
Fully automated, sequential focused ion beam milling for cryo-electron tomography Open
Cryo-electron tomography (cryoET) has become a powerful technique at the interface of structural biology and cell biology, due to its unique ability for imaging cells in their native state and determining structures of macromolecular compl…
View article: Author response: Fully automated, sequential focused ion beam milling for cryo-electron tomography
Author response: Fully automated, sequential focused ion beam milling for cryo-electron tomography Open
View article: Fully automated, sequential focused ion beam milling for cryo-electron tomography
Fully automated, sequential focused ion beam milling for cryo-electron tomography Open
Cryo-electron tomography (cryoET) has become a powerful technique at the interface of structural biology and cell biology, with the unique ability to determine structures of macromolecular complexes in their cellular context. A major limit…
View article: Supplemental material: Intercellular Pathways from the Vasculature to the Forming Bone in the Zebrafish Larval Caudal Fin: Possible Role in Bone Formation. JSB 2019
Supplemental material: Intercellular Pathways from the Vasculature to the Forming Bone in the Zebrafish Larval Caudal Fin: Possible Role in Bone Formation. JSB 2019 Open
This dataset includes five videos and four raw data-sets that are part of the article “Intercellular Pathways from the Vasculature to the Forming Bone in the Zebrafish Larval Caudal Fin: Possible Role in Bone Formation”. The data set conta…
View article: Biomineralization Pathways in Calcifying Dinoflagellates: Uptake, Storage in MgCaP-Rich Bodies and Formation of the Shell
Biomineralization Pathways in Calcifying Dinoflagellates: Uptake, Storage in MgCaP-Rich Bodies and Formation of the Shell Open
View article: Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction Open
Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to …
View article: Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction Open
Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to …
View article: Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo <scp>FIB</scp> / <scp>SEM</scp> Tomography
Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo <span>FIB</span> / <span>SEM</span> Tomography Open
The investigation of vitrified biological specimens (i.e. samples that are plunge or high pressure frozen) enables the visualization of cellular ultrastructure in a near native fully hydrated state, unadulterated by harmful preparation me…
View article: Calcium transport into the cells of the sea urchin larva in relation to spicule formation
Calcium transport into the cells of the sea urchin larva in relation to spicule formation Open
Significance A major challenge in biomineralization is to determine the pathways by which calcium is transferred from external sources to the mineralization site. Using the membrane-impermeable calcium-binding dye calcein and fluorescent d…
View article: Cryo-FIB-SEM serial milling and block face imaging: Large volume structural analysis of biological tissues preserved close to their native state
Cryo-FIB-SEM serial milling and block face imaging: Large volume structural analysis of biological tissues preserved close to their native state Open
View article: A vacuole-like compartment concentrates a disordered calcium phase in a key coccolithophorid alga
A vacuole-like compartment concentrates a disordered calcium phase in a key coccolithophorid alga Open
View article: Mineral-bearing vesicle transport in sea urchin embryos
Mineral-bearing vesicle transport in sea urchin embryos Open
View article: Correlative large volume imaging across scales
Correlative large volume imaging across scales Open
View article: Live cell immunogold labelling of RNA polymerase II
Live cell immunogold labelling of RNA polymerase II Open
View article: Developing 3D SEM in a broad biological context
Developing 3D SEM in a broad biological context Open
Summary When electron microscopy (EM) was introduced in the 1930s it gave scientists their first look into the nanoworld of cells. Over the last 80 years EM has vastly increased our understanding of the complex cellular structures that und…